scholarly journals The pleiotropic cardiovascular effects of dipeptidyl peptidase-4 inhibitors

2018 ◽  
Vol 84 (8) ◽  
pp. 1686-1695 ◽  
Author(s):  
Angelo Avogaro ◽  
Gian Paolo Fadini
Keyword(s):  
Cardiovascular Effects ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitors

Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: A meta-analysis

2015 ◽  
Vol 181 ◽  
pp. 239-244 ◽  
Author(s):  
Gianluigi Savarese ◽  
Pasquale Perrone-Filardi ◽  
Carmen D'Amore ◽  
Cristiana Vitale ◽  
Bruno Trimarco ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Cardiovascular Effects ◽  
Dipeptidyl Peptidase ◽  
Diabetic Patients ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitors

scholarly journals THEEFFECT OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS ON CARDIOVASCULAR DISEASE RISK IN TYPE 2 DIABETES MELLITUS

2016 ◽  
Vol 9 (1) ◽  
pp. 254
Author(s):  
Marwa K.a. Tolba ◽  
Khaled A. El Khashab ◽  
Amira S.a. Said
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Effects ◽  
Dipeptidyl Peptidase ◽  
Ventricular Performance ◽  
Dipeptidyl Peptidase 4 ◽  
Coronary Syndrome ◽  
Dipeptidyl Peptidase 4 Inhibitors

<p><strong>Objective: </strong>The aim of this study was is to investigate the proposed beneficial cardiovascular effects of a novel class of antidiabetic drugs named; dipeptidyl peptidase 4 inhibitors. In this study, we compared the effect of using add-on therapy of vildagliptin (dipeptidyl peptidase-4 inhibitor; DPP-4i) and gliclazide (sulphonylurea; SU) to that when using gliclazide monotherapy in patients with type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS) on different cardiovascular outcomes.<strong></strong></p><p><strong>Methods: </strong>A total of 60 patients diagnosed with T2DM, and ACS were randomly recruited into two treatment groups each of 30 patients to receive either gliclazide monotherapy (SU) or vildagliptin (DPP4i)+gliclazide (SU) add-on therapy, administered in a double-blind fashion. Outpatient visits were scheduled at 3, 6, and 12 mo where patient was reevaluated for cardiovascular (CV) outcomes and followed up for any arising cardiovascular complication.<strong></strong></p><p><strong>Results: </strong>The vildagliptin (DPP4i) plus gliclazide (SU) add-on therapy group have significantly shown more improved glycemic control, lipid profile and ventricular performance compared to gliclazide (SU) monotherapy group with p values&lt;0.05.<strong></strong></p><p dir="LTR"><strong>Conclusion: </strong>Vildagliptin as a DPP4i provides favourable cardiovascular effects beyond glucose control. Yet, its long-term safety and efficacy data still needs further investigations.</p>

scholarly journals The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Na-Hyung Kim ◽  
Taeyang Yu ◽  
Dae Ho Lee
Keyword(s):  
Randomized Clinical Trials ◽  
Cardiovascular Effects ◽  
Dipeptidyl Peptidase ◽  
Protective Effects ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitors ◽  
Glucagon Like Peptide 1 ◽  
Stimulation Of

A cell surface serine protease, dipeptidyl peptidase 4 (DPP-4), cleaves dipeptide from peptides containing proline or alanine in the N-terminal penultimate position. Two important incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), enhance meal-stimulated insulin secretion from pancreaticβ-cells, but are inactivated by DPP-4. Diabetes and hyperglycemia increase the DPP-4 protein level and enzymatic activity in blood and tissues. In addition, multiple other functions of DPP-4 suggest that DPP-4 inhibitor, a new class of antidiabetic agents, may have pleiotropic effects. Studies have shown that DPP-4 itself is involved in the inflammatory signaling pathway, the stimulation of vascular smooth cell proliferation, and the stimulation of oxidative stress in various cells. DPP-4 inhibitor ameliorates these pathophysiologic processes and has been shown to have cardiovascular protective effects in bothin vitroandin vivoexperiments. However, in recent randomized clinical trials, DPP-4 inhibitor therapy in high risk patients with type 2 diabetes did not show cardiovascular protective effects. Some concerns on the actions of DPP-4 inhibitor include sympathetic activation and neuropeptide Y-mediated vascular responses. Further studies are required to fully characterize the cardiovascular effects of DPP-4 inhibitor.

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