scholarly journals Population pharmacokinetic meta‐analysis of ramucirumab in cancer patients

2017 ◽  
Vol 83 (12) ◽  
pp. 2741-2751 ◽  
Author(s):  
Lisa O'Brien ◽  
Paul Westwood ◽  
Ling Gao ◽  
Michael Heathman
Keyword(s):  
Cancer Patients ◽  
Meta Analysis ◽  
Population Pharmacokinetic

scholarly journals A Population Pharmacokinetic Meta‐analysis of Veliparib, a PARP Inhibitor, Across Phase I/II/III Trials in Cancer Patients

2021 ◽  
Author(s):  
Sven Stodtmann ◽  
Silpa Nuthalapati ◽  
Doerthe Eckert ◽  
Sreeneeranj Kasichayanula ◽  
Rujuta Joshi ◽  
...  
Keyword(s):  
Phase I ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Parp Inhibitor ◽  
Population Pharmacokinetic

Population Pharmacokinetic Meta-Analysis of Trabectedin (ET-743,??Yondelis??) in Cancer Patients

2007 ◽  
Vol 46 (10) ◽  
pp. 867-884 ◽  
Author(s):  
Juan Jose Perez-Ruixo ◽  
Peter Zannikos ◽  
Sarapee Hirankarn ◽  
Kim Stuyckens ◽  
Elizabeth A Ludwig ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Meta Analysis ◽  
Population Pharmacokinetic

Thrombosis in Cancer Patients Treated with Hematopoietic Growth Factors - A Meta-Analysis

1996 ◽  
Vol 75 (02) ◽  
pp. 368-371 ◽  
Author(s):  
T Barbul ◽  
G Finazzi ◽  
A Grassi ◽  
R Marchioli
Keyword(s):  
Cancer Patients ◽  
Case Reports ◽  
Meta Analysis ◽  
Case Series ◽  
Hematopoietic Growth Factors ◽  
Patients With Cancer ◽  
Cytotoxic Treatment ◽  
Pertinent Data ◽  
Thrombotic Complications ◽  
Vascular Occlusions

SummaryHematopoietic colony-stimulating factors (CSFs) are largely used in patients with cancer undergoing cytotoxic treatment to accelerate neutrophil recovery and decrease the incidence of febrile neutropenia. Clinical practice guidelines for their use have been recently established (1), taking into account clinical benefit, but also cost and toxicity. Vascular occlusions have been recently reported among the severe reactions associated with the use of CSFs, in anedoctal case reports (2, 3), consecutive case series (4) and randomized clinical trial (5, 6). However, the role of CSFs in the pathogenesis of thrombotic complications is difficult to ascertain, because pertinent data are scanty and widely distributed over a number of heterogenous investigations. We report here a systematic review of relevant articles, with the aims to estimate the prevalence of thrombosis associated with the use of CSFs and to assess if this rate is significantly higher than that observed in cancer patients not receiving CSFs.

Coronavirus Disease (COVID-19) in Cancer Patients: A Systematic Review and Meta-Analysis to Evaluate Severity and Fatal Outcomes

2020 ◽  
Author(s):  
Abhijeet Ashok Salunke ◽  
Kunal Nandy ◽  
Subodh Kumar Pathak ◽  
Ketul Puj ◽  
Vikas Warikoo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis

ctDNA as a prognostic factor in operable colon cancer patients: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Emre Yekedüz ◽  
Elif Berna Köksoy ◽  
Hakan Akbulut ◽  
Yüksel Ürün ◽  
Güngör Utkan
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Circulating Tumor Dna ◽  
Random Effects Model ◽  
Inverse Variance ◽  
Increased Risk ◽  
Significant Step ◽  
Tumor Dna

Aim: Using circulating tumor DNA (ctDNA) instead of historical clinicopathological factors to select patients for adjuvant chemotherapy (ACT) may reduce inappropriate therapy. Material & methods: MEDLINE was searched on March 31, 2020. Studies, including data related to the prognostic value of ctDNA in the colon cancer patients after surgery and after ACT, were included. The generic inverse-variance method with a random-effects model was used for meta-analysis. Results: Four studies were included for this meta-analysis. ctDNA-positive colon cancer patients after surgery and ACT had a significantly increased risk of recurrence compared with ctDNA-negative patients. Conclusions: ctDNA is an independent prognostic factor, and this meta-analysis is a significant step for using ctDNA instead of historical prognostic factors in the adjuvant setting.

Sign in / Sign up

Export Citation Format

Share Document