scholarly journals Quantitative efficacy of topical administration of tranexamic acid on postoperative bleeding in total knee arthroplasty

2017 ◽  
Vol 83 (11) ◽  
pp. 2485-2493 ◽  
Author(s):  
Ruijuan Xu ◽  
Dongquan Shi ◽  
Weihong Ge ◽  
Qing Jiang
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Postoperative Bleeding ◽  
Topical Administration ◽  
Total Knee

Topical Administration of Tranexamic Acid in Primary Total Hip and Total Knee Arthroplasty

2014 ◽  
Vol 29 (5) ◽  
pp. 889-894 ◽  
Author(s):  
Joseph G. Martin ◽  
Kevin B. Cassatt ◽  
Katie A. Kincaid-Cinnamon ◽  
Denise S. Westendorf ◽  
Ann S. Garton ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Topical Administration ◽  
Total Hip ◽  
Total Knee

scholarly journals Daily blood loss transition after total knee arthroplasty with topical administration of tranexamic acid: Paradoxical blood loss after action of tranexamic acid

2020 ◽  
Vol 28 (1) ◽  
pp. 230949901989581 ◽  
Author(s):  
Sang Jun Song ◽  
Hyun Woo Lee ◽  
Dae Kyung Bae ◽  
Cheol Hee Park
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Reduction Rate ◽  
Topical Administration ◽  
Level Of Evidence ◽  
Total Blood ◽  
Level Ii ◽  
Total Knee

Purpose: The purpose of this study was to compare the daily blood loss transition between groups with and without topical administration of tranexamic acid (TXA) after cruciate retaining (CR) and posterior stabilized (PS) total knee arthroplasty (TKA). Methods: A total of 220 patients undergoing unilateral TKA were enrolled in CR and PS TKAs, which were divided into groups that received topical administration of TXA (TXA group) or without TXA (non-TXA group). Each group in both types of TKA included 55 patients. The daily transition of blood loss was compared between the TXA and the non-TXA groups in CR and PS TKAs. The blood loss was calculated through Nadler formula using the patient’s blood volume and hemoglobin reduction rate. Results: Total blood loss was significantly lower in the TXA group in both CR and PS TKAs ( p < 0.001, respectively). The blood loss was lower for 0–24 h and 24–48 h after TKA. However, from 48 h to 72 h, it was greater in the TXA group (253.1 vs. 34.6 mL; p < 0.001) in CR TKAs. These tendencies were similar in PS TKAs after 48 h (186.2 vs. 134.9 mL, p = 0.223). Conclusions: Topical administration of TXA for reduction of blood loss seemed to be effective up to 48 h after both CR and PS TKAs. The blood loss after 48 h tended to be even greater in the TXA group. Future studies will be required to identify the pharmacokinetic evidence for this clinical finding. Level of evidence: Level II.

scholarly journals Optimal Release Timing of Temporary Drain Clamping to Reduce Postoperative Bleeding After Total Knee Arthroplasty With an Intraarticular Injection of Tranexamic Acid

2021 ◽  
Author(s):  
Myung Ku Kim ◽  
Sang Hyun Ko ◽  
Yoon Cheol Nam ◽  
Yoon Sang Jeon ◽  
Won Hwan Kwon ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Postoperative Bleeding ◽  
Intraarticular Injection ◽  
Wound Complications ◽  
Transfusion Rate ◽  
Vein Thrombosis ◽  
Total Knee ◽  
Drain Clamping

Abstract Background: Intraarticular injection of tranexamic acid (IA-TXA) plus drain-clamping is a preferred method of reducing bleeding after total knee arthroplasty (TKA). However, no consensus had been reached regarding the timing of clamping. The purpose of this study was to determine the optimum duration of drain-clamping after TKA with IA-TXA.Methods: We retrospectively reviewed 151 patients that underwent unilateral TKA with IA-TXA plus drain-clamping for 30 minutes (Group A, 60 patients), 2 hours (Group B, 42 patients), or 3 hours (Group C, 49 patients). Total drained volumes, hematocrit (Hct) reductions, estimated blood losses (EBLs), transfusion rates, and wound complications were reviewed.Results: Mean total drained volume, Hct reduction, EBL, and transfusion rate were significantly less in group C than in groups A or B (p < 0.01). No significant intergroup difference was found for wound-related complications. No surgical site infection or deep vein thrombosis was observed.Conclusion: IA-TXA plus drain-clamping for 3 hours is optimal for reducing blood loss with minimal complications after TKA.

scholarly journals Effects of topical administration of tranexamic acid on blood loss in total knee arthroplasty: A retrospective study (topical use of tranexamic acid in total knee arthroplasty)

2021 ◽  
Vol 43 (3-4) ◽  
pp. 53-60
Author(s):  
Marijana Milovanović ◽  
Igor Vasković ◽  
Vojislava Nešković
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Demographic Data ◽  
Topical Administration ◽  
Postoperative Blood Loss ◽  
Intraoperative Bleeding ◽  
Perioperative Bleeding ◽  
Total Knee

Introduction: Total knee arthroplasty (TKA) is a complex surgical intervention. By 2030, TKA is expected to reach as much as 3.48 million interventions yearly. Perioperative bleeding is a major problem in TKA, with intraoperative blood loss from 300 to 2000 ml. In orthopedic surgery, tranexamic acid (TXA) has been used to prevent blood loss and enable faster recovery. Here we present the first experience of topically applied tranexamic acid for TKA in our hospital. Method: The effects of topical use of TXA on bleeding for the one-year period were retrospectively analyzed. Comparisons were made between two groups: the T-TK group in which TXA was topically applied, and the 0-TK group, in which the drug was not used. Demographic data, hemoglobin and hematocrit, transfusion of allogeneic blood products, intraoperative and postoperative blood loss, anticoagulant and antiplatelet therapy, and the occurrence of postoperative complications were analyzed. Results: The study included 104 patients, 35 in the T-TK group and 69 in the 0-TK group. It was shown that patients with significantly higher intraoperative bleeding received topical TXA. Patients in the T-TK group received fewer transfusions on the first, fourth, fifth, and sixth days. Conclusion: Analysis of the initial use of topical tranexamic acid in our hospital indicates that patients with more intraoperative bleeding were those to receive the treatment. There is a need for better-defined indications for the topical use of TXA, particularly as an alternative for patients who are at higher risk of developing thromboembolic complications.

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