scholarly journals Psychotropics and weak opioid analgesics in plasma samples of older hip fracture patients - detection frequencies and consistency with drug records

2017 ◽  
Vol 83 (7) ◽  
pp. 1397-1404 ◽  
Author(s):  
Ragnhild Birkeland Waade ◽  
Espen Molden ◽  
Mette Irene Martinsen ◽  
Monica Hermann ◽  
Anette Hylen Ranhoff
Keyword(s):  
Hip Fracture ◽  
Opioid Analgesics ◽  
Plasma Samples ◽  
Weak Opioid

Weak Opioid Analgesics Abuse and Addiction

2016 ◽  
pp. 375-391 ◽  
Author(s):  
Anne Roussin ◽  
Aurore Palmaro ◽  
Maryse Lapeyre-Mestre
Keyword(s):  
Opioid Analgesics ◽  
Weak Opioid

Abuse of Weak Opioid Analgesics

1984 ◽  
Vol 3 (1_suppl) ◽  
pp. 229s-236S ◽  
Author(s):  
M. Lader
Keyword(s):  
Opioid Analgesics ◽  
Weak Opioid

Opioid Analgesics and the Risk of Hip Fracture in the Elderly: Codeine and Propoxyphene

1992 ◽  
Vol 47 (4) ◽  
pp. M111-M115 ◽  
Author(s):  
R. I. Shorr ◽  
M. R. Griffin ◽  
J. R. Daugherty ◽  
W. A. Ray
Keyword(s):  
Hip Fracture ◽  
Opioid Analgesics ◽  
The Elderly

scholarly journals Hip Fracture Risk among Hemodialysis-Dependent Patients Prescribed Opioids and Gabapentinoids

2020 ◽  
Vol 31 (6) ◽  
pp. 1325-1334 ◽  
Author(s):  
Chandan Vangala ◽  
Jingbo Niu ◽  
Maria E. Montez-Rath ◽  
Jingyin Yan ◽  
Sankar D. Navaneethan ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Fracture Risk ◽  
Conditional Logistic Regression ◽  
Opioid Analgesics ◽  
The United States ◽  
Opioid Use ◽  
Short Term ◽  
Part D ◽  
Hip Fracture Risk ◽  
Short Term Exposure

BackgroundDespite opioids’ known association with hip fracture risk in the general population, they are commonly prescribed to patients with ESKD. Whether use of opioids or gabapentinoids (also used to treat pain in patients with ESKD) contributes to hip fracture risk in patients with ESKD on hemodialysis remains unknown.MethodsIn a case-control study nested within the US Renal Data System, we identified all hip fracture events recorded among patients dependent on hemodialysis from January 2009 through September 2015. Eligible cases were risk-set matched on index date with ten eligible controls. We required >1 year of Medicare Parts A and B coverage and >3 years of part D coverage to study cumulative longer-term exposure. To examine new, short-term exposure, we selected individuals with >18 months of Part D coverage and no prior opioid or gabapentinoid use between 18 and 7 months before index. We used conditional logistic regression to estimate unadjusted and multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CI).ResultsFor the longer-term analyses, we identified 4912 first-time hip fracture cases and 49,120 controls. Opioid use was associated with increased hip fracture risk (adjusted OR, 1.39; 95% CI, 1.26 to 1.53). Subgroups of low, moderate, and high use yielded adjusted ORs of 1.33 (95% CI, 1.20 to 1.47), 1.53 (95% CI, 1.36 to 1.72), and 1.66 (95% CI, 1.45 to 1.90), respectively. The association with hip fractures was also elevated with new, short-term use (adjusted OR, 1.38; 95% CI, 1.25 to 1.52). There were no associations between gabapentinoid use and hip fracture.ConclusionsAmong patients dependent on hemodialysis in the United States, both short-term and longer-term use of opioid analgesics were associated with hip fracture events.

scholarly journals Relationship Between Pain and Opioid Analgesics on the Development of Delirium Following Hip Fracture

2003 ◽  
Vol 58 (1) ◽  
pp. M76-M81 ◽  
Author(s):  
R. S. Morrison ◽  
J. Magaziner ◽  
M. Gilbert ◽  
K. J. Koval ◽  
M. A. McLaughlin ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Opioid Analgesics

Stability of antioxidant vitamins in whole human blood during overnight storage at 4°C and frozen storage up to 6 months

2018 ◽  
Vol 88 (3-4) ◽  
pp. 151-157 ◽  
Author(s):  
Scott W. Leonard ◽  
Gerd Bobe ◽  
Maret G. Traber
Keyword(s):  
Ascorbic Acid ◽  
Whole Blood ◽  
Healthy Subjects ◽  
Frozen Storage ◽  
Blood Collection ◽  
Plasma Samples ◽  
Optimal Conditions ◽  
Plasma Ascorbic Acid ◽  
Blood Samples ◽  
Sample Handling

Abstract. To determine optimal conditions for blood collection during clinical trials, where sample handling logistics might preclude prompt separation of erythrocytes from plasma, healthy subjects (n=8, 6 M/2F) were recruited and non-fasting blood samples were collected into tubes containing different anticoagulants (ethylenediaminetetra-acetic acid (EDTA), Li-heparin or Na-heparin). We hypothesized that heparin, but not EDTA, would effectively protect plasma tocopherols, ascorbic acid, and vitamin E catabolites (α- and γ-CEHC) from oxidative damage. To test this hypothesis, one set of tubes was processed immediately and plasma samples were stored at −80°C, while the other set was stored at 4°C and processed the following morning (~30 hours) and analyzed, or the samples were analyzed after 6 months of storage. Plasma ascorbic acid, as measured using HPLC with electrochemical detection (LC-ECD) decreased by 75% with overnight storage using EDTA as an anticoagulant, but was unchanged when heparin was used. Neither time prior to processing, nor anticoagulant, had any significant effects upon plasma α- or γ-tocopherols or α- or γ-CEHC concentrations. α- and γ-tocopherol concentrations remained unchanged after 6 months of storage at −80°C, when measured using either LC-ECD or LC/mass spectrometry. Thus, refrigeration of whole blood at 4°C overnight does not change plasma α- or γ-tocopherol concentrations or their catabolites. Ascorbic acid is unstable in whole blood when EDTA is used as an anticoagulant, but when whole blood is collected with heparin, it can be stored overnight and subsequently processed.

Abhängigkeitspotenzial und andere Risiken von Opioidanalgetika im Alter

2017 ◽  
Vol 63 (2) ◽  
pp. 99-114 ◽  
Author(s):  
Dirk K. Wolter
Keyword(s):  
Adverse Effects ◽  
Psychische Störungen ◽  
Opioid Analgesics ◽  
Alte Menschen ◽  
Dsm 5 ◽  
Icd 10

Zusammenfassung. Zielsetzung: Übersicht über Suchtpotenzial und andere Risiken von Opioidanalgetika im höheren Lebensalter. Methodik: Narrativ review. Literaturrecherche in PubMed (Suchbegriffe: opioid analgesics UND abuse; opioid analgesics UND dependence; opioid analgesics UND addiction; opioid analgesics UND adverse effects; jeweils UND elderly) sowie aktuellen einschlägigen Standardwerken; Auswahl nach altersmedizinischer Relevanz und Aktualität. Ergebnisse: Die Verordnung von Opioidanalgetika (OA) hat in den letzten 25 Jahren massiv zugenommen, die weitaus meisten Verordnungen entfallen auf alte Menschen und Menschen mit chronischen Nicht-Tumorschmerzen (CNTS). Die diagnostischen Kriterien für die Opiatabhängigkeit in ICD-10 und DSM-5 sind für die OA-Behandlung von CNTS ungeeignet. Bei langfristiger OA-Behandlung bei CNTS kann eine spezifische Form von Abhängigkeit entstehen, die nicht mit der illegalen Opiat-(Heroin-)Sucht gleichzusetzen ist. Vorbestehende Suchterkrankungen und andere psychische Störungen sind die wesentlichsten Risikofaktoren. Weitere Nebenwirkungen sind zu beachten. Schmerztherapie bei Suchtkranken stellt eine besondere Herausforderung dar. Schlussfolgerungen: Die Anwendung von OA bei CNTS verlangt eine sorgfältige Indikationsstellung. Die besondere Form der Abhängigkeit von OA ist nicht ausreichend erforscht und wird zu wenig beachtet.

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