scholarly journals Pharmacological treatment of cardiac glycoside poisoning

2015 ◽  
Vol 81 (3) ◽  
pp. 488-495 ◽  
Author(s):  
Darren M. Roberts ◽  
Gamini Gallapatthy ◽  
Asunga Dunuwille ◽  
Betty S. Chan
Keyword(s):  
Cardiac Glycoside ◽  
Pharmacological Treatment ◽  
Glycoside Poisoning

scholarly journals A krimpsiekte-like syndrome in small stock poisoned by Ornithogalum toxicarium Archer & Archer

2000 ◽  
Vol 71 (1) ◽  
Author(s):  
C.J. Botha ◽  
R.A. Schultz ◽  
J.J. Van der Lugt ◽  
C. Archer
Keyword(s):  
South Africa ◽  
Cardiac Glycoside ◽  
Plant Material ◽  
Western Cape ◽  
Western Cape Province ◽  
Fresh Plant Material ◽  
Small Stock ◽  
First Time ◽  
Glycoside Poisoning ◽  
Fluorescence Polarisation

Krimpsiekte (the syndrome associated with chronic cardiac glycoside poisoning) was purportedly induced by Ornithogalum toxicarium in the Karas mountains area of Keetmanshoop, Namibia. This chinkerinchee species was previously linked to a condition known as 'kwylbek' krimpsiekte in small stock in the Beaufort West district of the Western Cape Province, South Africa. In a dosing trial, respiratory distress, tachycardia and sternal recumbency were observed in 2 sheep drenched with fresh plant material. A fluorescence polarisation immunoassay (FPIA) detected the presence of a substance that cross-reacted with digoxin antibodies in some of the plant material collected at Keetmanshoop and Beaufort West. This is the first time that apparent cardiac glycoside poisoning was induced by a southern African chinkerinchee species. The presence of the cardiac glycoside-like substance in O. toxicarium requires further chemical verification.

scholarly journals The role of fluorescence polarization immuno-assay in the diagnosis of plant-induced cardiac glycoside poisoning livestock in South Africa

2005 ◽  
Vol 72 (3) ◽  
Author(s):  
R.A. Schultz ◽  
T.S. Kellerman ◽  
H. Van den Berg
Keyword(s):  
Cardiac Glycoside ◽  
Fluorescence Polarization ◽  
Cardiac Glycosides ◽  
Negative Results ◽  
Immuno Assay ◽  
Considerable Benefit ◽  
Chemical Procedure ◽  
Glycoside Poisoning ◽  
Veterinary Institute

Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical chemical procedure indicating the presence of cardiac glycosides in plants and animal specimens would be of considerable benefit. The fluorescence polarization immunoassay (FPIA) method, used to determine digoxin plasma levels in humans and dogs, was adapted to estimate cardiac glycoside levels in known cardiac-glycoside- containing plants as well as in the rumen and organs of dosed sheep. Positive FPIA values were obtained with bufadienolide-containing plants, while negative results were obtained with plants not known to contain cardiac glycosides. The FPIA has aided in the diagnosis of cardiac glycoside poisoning in livestock and game in 30 outbreaks examined at the Division of Toxicology, Onderstepoort Veterinary Institute. Each outbreak is briefly described. As a result of this assay, a better understanding of cardiac glycoside poisoning has been reached.

scholarly journals Two cases of cardiac glycoside poisoning from accidental foxglove ingestion

2016 ◽  
Vol 188 (10) ◽  
pp. 747-750 ◽  
Author(s):  
Renée M. Janssen ◽  
Mattias Berg ◽  
Daniel H. Ovakim
Keyword(s):  
Cardiac Glycoside ◽  
Glycoside Poisoning

scholarly journals Kalanchoe lanceolata poisoning in Brahman cattle in Zimbabwe : the first field outbreak : case report

1997 ◽  
Vol 68 (1) ◽  
Author(s):  
C. Masvingwe ◽  
M. Mavenyengwa
Keyword(s):  
Case Report ◽  
Cardiac Glycoside ◽  
Clinical Signs ◽  
Pathological Lesions ◽  
Commercial Farm ◽  
Brahman Cattle ◽  
Glycoside Poisoning ◽  
Outbreak Case

Field outbreaks of Kalanchoe lanceolata poisoning in cattle on a commercial farm in Zimbabwe are reported. The clinical signs and pathological lesions observed in field cases resembled those reproduced in an experimental cow and were consistent with acute cardiac glycoside poisoning.

Cardiac glycoside poisoning following suicidal ingestion ofCerbera manghas

2008 ◽  
Vol 46 (4) ◽  
pp. 340-341 ◽  
Author(s):  
Yi-Cheng Tsai ◽  
Chun-Yu Chen ◽  
Ning-I Yang ◽  
Chen-Chang Yang
Keyword(s):  
Cardiac Glycoside ◽  
Glycoside Poisoning

An unusual electrocardiographic pattern of cardiac glycoside poisoning

2002 ◽  
Vol 82 (1) ◽  
pp. 79-81
Author(s):  
Luca Lanzarini ◽  
Paolo Lanzarini ◽  
Alberto Casazza
Keyword(s):  
Cardiac Glycoside ◽  
Glycoside Poisoning

Detection of poisoning by plant-origin cardiac glycoside with the Abbott TDx analyzer.

1989 ◽  
Vol 35 (2) ◽  
pp. 295-297 ◽  
Author(s):  
K Cheung ◽  
J A Hinds ◽  
P Duffy
Keyword(s):  
Cardiac Glycoside ◽  
Plant Material ◽  
Cardiac Glycosides ◽  
Digoxin Concentration ◽  
Cross Reactivity ◽  
Nerium Oleander ◽  
Tropical Areas ◽  
Competitive Nature ◽  
Toad Bufo ◽  
Glycoside Poisoning

Abstract Cardiac glycoside poisoning caused by ingestion of plant material is common in tropical and sub-tropical areas. In evaluating the use of the Abbott TDx Digoxin II assay to detect such cases of poisoning, we found it a rapid and convenient method for confirming the ingestion of glycosides from the plants Nerium oleander, Thevetia peruviana, and Adonis microcarpa, and from the toad Bufo marinus. Here we report some clinical cases illustrating our experience with the use of this assay, and describe results of cross-reactivity studies with compounds structurally similar to digoxin. Because of the competitive nature of the immunoassay as well as the complexity of the mixture of cross-reacting cardiac glycosides present in the plant material, the measured apparent digoxin concentration is not linearly related to the cardiac glycoside concentration.

Letter in response to “fatal cardiac glycoside poisoning due to mistaking foxglove for comfrey”

2017 ◽  
Vol 56 (6) ◽  
pp. 447-449 ◽  
Author(s):  
Adrienne Hughes ◽  
Robert G. Hendrickson ◽  
Betty Chia-Chi Chen ◽  
Matthew Valento
Keyword(s):  
Cardiac Glycoside ◽  
Glycoside Poisoning
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