scholarly journals Time-trends in the prescribing of gastroprotective agents to primary care patients initiating low-dose aspirin or non-steroidal anti-inflammatory drugs: a population-based cohort study

2015 ◽  
Vol 80 (3) ◽  
pp. 589-598 ◽  
Author(s):  
Margaretha F. Warlé-van Herwaarden ◽  
Aafke R. Koffeman ◽  
Vera E. Valkhoff ◽  
Geert W. ’t Jong ◽  
Cornelis Kramers ◽  
...  
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Time Trends ◽  
Low Dose ◽  
Population Based ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Primary Care Patients ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Dose-dependent roles of aspirin and other non-steroidal anti-inflammatory drugs in abnormal bone remodeling and skeletal regeneration

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yong Xie ◽  
Meng Pan ◽  
Yanpan Gao ◽  
Licheng Zhang ◽  
Wei Ge ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Remodeling ◽  
Low Dose ◽  
High Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
High Dose Aspirin

AbstractThe failure of remodeling process that constantly regenerates effete, aged bone is highly associated with bone nonunion and degenerative bone diseases. Numerous studies have demonstrated that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) activate cytokines and mediators on osteoclasts, osteoblasts and their constituent progenitor cells located around the remodeling area. These cells contribute to a complex metabolic scenario, resulting in degradative or synthetic functions for bone mineral tissues. The spatiotemporal effects of aspirin and NSAIDs in the bone remodeling are controversial according the specific therapeutic doses used for different clinical conditions. Herein, we review in vitro, in vivo, and clinical studies on the dose-dependent roles of aspirin and NSAIDs in bone remodeling. Our results show that low-dose aspirin (< 100 μg/mL), which is widely recommended for prevention of thrombosis, is very likely to be benefit for maintaining bone mass and qualities by activation of osteoblastic bone formation and inhibition of osteoclast activities via cyclooxygenase-independent manner. While, the roles of high-dose aspirin (150–300 μg/mL) and other NSAIDs in bone self-regeneration and fracture-healing process are difficult to elucidate owing to their dual effects on osteoclast activity and bone formation of osteoblast. In conclusion, this study highlighted the potential clinical applications of low-dose aspirin in abnormal bone remodeling as well as the risks of high-dose aspirin and other NSAIDs for relieving pain and anti-inflammation in fractures and orthopedic operations.

scholarly journals Low-dose aspirin and survival from lung cancer: a population-based cohort study

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Úna C. Mc Menamin ◽  
Chris R. Cardwell ◽  
Carmel M. Hughes ◽  
Liam M. Murray
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Low Dose ◽  
Population Based ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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