Investigation of mutual pharmacokinetic interactions between macitentan, a novel endothelin receptor antagonist, and sildenafil in healthy subjects

Patricia N. Sidharta; Paul L. M. van Giersbergen; Michael Wolzt; Jasper Dingemanse

doi:10.1111/bcp.12447

Investigation of mutual pharmacokinetic interactions between macitentan, a novel endothelin receptor antagonist, and sildenafil in healthy subjects

British Journal of Clinical Pharmacology ◽

10.1111/bcp.12447 ◽

2014 ◽

Vol 78 (5) ◽

pp. 1035-1042 ◽

Cited By ~ 14

Author(s):

Patricia N. Sidharta ◽

Paul L. M. van Giersbergen ◽

Michael Wolzt ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetic Interactions

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Lack Of Clinically Relevant Pharmacokinetic Interactions Between The Dual Endothelin Receptor Antagonist Macitentan And Sildenafil In Healthy Subjects

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4802 ◽

2012 ◽

Cited By ~ 1

Author(s):

P N. Sidharta ◽

P L.M. van Giersbergen ◽

Michael Wolzt ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetic Interactions

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Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2002.01158.x ◽

2002 ◽

Vol 53 (4) ◽

pp. 355-362 ◽

Cited By ~ 26

Author(s):

Jasper Dingemanse ◽

Martine Clozel ◽

Paul L. M. Van Giersbergen

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Chronic Infusion

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects

The Journal of Clinical Pharmacology ◽

10.1002/jcph.152 ◽

2013 ◽

pp. n/a-n/a ◽

Cited By ~ 15

Author(s):

Patricia N. Sidharta ◽

Paul L. M. van Giersbergen ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Multiple Dose ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Multiple Dose Study ◽

Dose Study

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Investigation of the Mutual Pharmacokinetic Interactions Between Bosentan, a Dual Endothelin Receptor Antagonist, and Simvastatin

Clinical Pharmacokinetics ◽

10.2165/00003088-200342030-00004 ◽

2003 ◽

Vol 42 (3) ◽

pp. 293-301 ◽

Cited By ~ 33

Author(s):

Jasper Dingemanse ◽

Dieter Schaarschmidt ◽

Paul L.M. van Giersbergen

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetic Interactions

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Dose-Dependent Acute and Sustained Renal Effects of the Endothelin Receptor Antagonist Avosentan in Healthy Subjects

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2009.15 ◽

2009 ◽

Vol 85 (6) ◽

pp. 628-634 ◽

Cited By ~ 24

Author(s):

J Smolander ◽

B Vogt ◽

M Maillard ◽

C Zweiacker ◽

T Littke ◽

...

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Renal Effects ◽

Dose Dependent

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Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2002.16138.x ◽

2002 ◽

Vol 53 (5) ◽

pp. 547P-547P ◽

Cited By ~ 2

Author(s):

J. Dingemanse ◽

D. Schaarschmidt ◽

P. L. M. Van Giersbergen

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetic Interactions

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Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2043 ◽

2020 ◽

Author(s):

Pierre Gueneau de Mussy ◽

Patricia N. Sidharta ◽

Gregoire Wuerzner ◽

Marc P. Maillard ◽

Nicolas Guérard ◽

...

Keyword(s):

Body Weight ◽

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

High Sodium ◽

Fluid Homeostasis ◽

Sodium Diet ◽

High Sodium Diet

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Macitentan, a dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension, does not affect cardiac repolarization in healthy subjects

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2014.04.007 ◽

2014 ◽

Vol 29 (1) ◽

pp. 41-48 ◽

Cited By ~ 5

Author(s):

Nicolas Lindegger ◽

Patricia N. Sidharta ◽

Kathrin Reseski ◽

Jasper Dingemanse

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Cardiac Repolarization ◽

Endothelin Receptor ◽

Pulmonary Arterial

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Investigation of the Effects of Ketoconazole on the Pharmacokinetics of Macitentan, a Novel Dual Endothelin Receptor Antagonist, in Healthy Subjects

Clinical Pharmacokinetics ◽

10.1007/s40262-013-0063-8 ◽

2013 ◽

Vol 52 (8) ◽

pp. 685-692 ◽

Cited By ~ 31

Author(s):

Jacob Atsmon ◽

Jasper Dingemanse ◽

Dimitri Shaikevich ◽

Inna Volokhov ◽

Patricia N. Sidharta

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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Endothelin Receptor Antagonist

10.32388/54vclc ◽

2020 ◽

Author(s):

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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