scholarly journals Clopidogrel variability: role of plasma protein binding alterations

2013 ◽  
Vol 75 (6) ◽  
pp. 1468-1477 ◽  
Author(s):  
Shobana Ganesan ◽  
Craig Williams ◽  
Cheryl L. Maslen ◽  
Ganesh Cherala
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein

The Role of Plasma Protein Binding in Drug Discovery

2007 ◽  
pp. 119-141 ◽  
Author(s):  
Roger E. Fessey ◽  
Rupert P. Austin ◽  
Patrick Barton ◽  
Andrew M. Davis ◽  
Mark C. Wenlock
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein

The Role of Plasma Protein Binding in Drug Delivery to Brain

2001 ◽  
pp. 311-321 ◽  
Author(s):  
Quentin R. Smith ◽  
Carolyn Fisher ◽  
David D. Allen
Keyword(s):  
Drug Delivery ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein

Pharmacodynamics of Alfentanil The Role of Plasma Protein Binding

1992 ◽  
Vol 76 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Harry J. M. Lemmens ◽  
Anton G. L. Burm ◽  
James G. Bovill ◽  
Pim J. Hennis ◽  
Marina P. R. R. Gladines
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein

Role of Divalent Metal Ions in Atypical Nonlinear Plasma Protein Binding Behavior of Tigecycline

2016 ◽  
Vol 105 (11) ◽  
pp. 3409-3414 ◽  
Author(s):  
Ravi Shankar Prasad Singh ◽  
Jatinder Kaur Mukker ◽  
Amelia N. Deitchman ◽  
Stephanie K. Drescher ◽  
Hartmut Derendorf
Keyword(s):  
Protein Binding ◽  
Metal Ions ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Nonlinear Plasma ◽  
Binding Behavior

Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis

Bioanalysis ◽  
2021 ◽  
Author(s):  
Sheelan Ahmad ◽  
Daniel Baker ◽  
Darragh Murnane ◽  
Neil Spooner ◽  
Ute Gerhard
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Equilibrium Dialysis ◽  
Free Concentration ◽  
Rapid Equilibrium

Aim: Determination of plasma protein binding ( PPB) is considered vital for better understanding of pharmacokinetic and pharmacodynamic activities of drugs due to the role of free concentration in pharmacological response. Methodology & results: Solid-phase microextraction (SPME) was investigated for measurement of PPB from biological matrices and compared with a gold standard approach (rapid equilibrium dialysis [RED]). Discussion & conclusion: SPME-derived values of PPB correlated well with literature values, and those determined by RED. Respectively, average protein binding across three concentrations by RED and SPME was 33.1 and 31.7% for metoprolol, 89.0 and 86.6% for propranolol and 99.2 and 99.0% for diclofenac. This study generates some evidence for SPME as an alternative platform for the determination of PPB.

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