scholarly journals Occurrence of pulsus alternans during anaesthesia of two dogs and one cat and its treatment

2020 ◽  
Author(s):  
D Nicholls ◽  
C Adami ◽  
P Monticelli
Keyword(s):  
Pulsus Alternans

scholarly journals Biventricular Pulsus Alternans in a Dog with Pulmonic Stenosis and Sepsis

CASE ◽  
2021 ◽  
Author(s):  
Wendy A. Ware ◽  
Adrienne B. Cheney ◽  
Shane Murphy
Keyword(s):  
Pulmonic Stenosis ◽  
Pulsus Alternans

Pulsus alternans induced by inferior vena caval occlusion in man

1988 ◽  
Vol 14 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Thomas M. Bashore ◽  
Stephen Walker ◽  
Douglas Van Fossen ◽  
Philip B. Shaffer ◽  
Mary E. Fontana ◽  
...  
Keyword(s):  
Inferior Vena ◽  
Inferior Vena Caval ◽  
Pulsus Alternans

Systolic and diastolic time intervals in pulsus alternans

1974 ◽  
Vol 87 (1) ◽  
pp. 5-10 ◽  
Author(s):  
David H. Spodick ◽  
Abdul H. Khan ◽  
Veronica M. Quarry
Keyword(s):  
Time Intervals ◽  
Pulsus Alternans ◽  
Diastolic Time

Regional electromechanical alternans in anesthetized pig hearts: modulation by mechanoelectric feedback

1994 ◽  
Vol 267 (5) ◽  
pp. H1726-H1735 ◽  
Author(s):  
C. F. Murphy ◽  
M. J. Lab ◽  
S. M. Horner ◽  
D. J. Dick ◽  
F. G. Harrison
Keyword(s):  
Left Ventricle ◽  
Action Potential ◽  
Monophasic Action Potential ◽  
Mechanical Activity ◽  
Strain Gauges ◽  
Atrial Pacing ◽  
Mechanoelectric Feedback ◽  
Pulsus Alternans ◽  
Electrical Alternans ◽  
Intact Heart

Electrical and mechanical alternans have often been found to coexist. However, the factors controlling their interdependence are not known. In this study we measure regional electrical and mechanical activity during mechanical alternans to investigate this relationship. Mechanical alternans was induced by rapid atrial pacing in 18 anesthetized, open-chest pigs. Regional segmental contraction and monophasic action potential were measured in three areas of left ventricle using epicardial tripodal strain gauges and suction electrodes. Electrical alternans always accompanied pulsus alternans. The phase of electrical alternans was not related to any measure of regional mechanical activity but did show a constant discordant relation to peak ventricular pressure. This suggested that mechanically dependent changes in action potential duration (mechanoelectric feedback) may be important in modulation electrical alternans. In support of this, pulsus alternans simulated by clamping the proximal aorta on alternate beats was associated with electrical alternans comparable to that produced with rapid atrial pacing. Mechanoelectric feedback modulates regional electrophysiology in the intact heart and may be important in the generation of electrical alternans.

Antagonism of drug-induced pulsus alternans in dogs

1960 ◽  
Vol 199 (1) ◽  
pp. 167-173 ◽  
Author(s):  
Charles H. Ellis
Keyword(s):  
Antiarrhythmic Drugs ◽  
Peripheral Resistance ◽  
Antiarrhythmic Activity ◽  
Sympathetic Nerves ◽  
Large Artery ◽  
Drug Induced ◽  
Intravenous Injections ◽  
Pulsus Alternans ◽  
Pharmacologic Agents ◽  
Procaine Amide

Pulsus alternans and pseudoalternans were produced in dogs anesthetized with pentobarbital by intravenous injections of moderate doses of one of several pharmacologic agents. Ventricular alternation was alleviated or abolished by a) drugs with positive inotropic action, b) drugs that reduced peripheral resistance, and c) drugs with antiarrhythmic activity. Digoxin and ouabain shortened the periods of drug-induced alternation. Norepinephrine and aminophylline promptly abolished pulsus alternans which had been experimentally established. Electrical stimulation of the cardiac sympathetic nerves resembled injected norepinephrine. Moderate does of nitroglycerin and large doses of histamine terminated pulsus alternans which had been evoked by methoxamine. Smaller doses of histamine were not always effective. Hexamethonium abolished alternation in the absence of marked vasoconstriction, but was ineffective against methoxamine-induced alternans. Hemorrhage from a large artery was effective. Quinidine promptly relieved pulsus alternans, as did two experimental antiarrhythmic drugs, o-methylcyclizine and B.W. 51–41. Procaine amide was not effective.

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