scholarly journals The effects of cisplatin, an emetic agent, on behavior and plasma cortisol levels in goats

2021 ◽  
Vol 92 (1) ◽  
Author(s):  
Masato Aoyama ◽  
Minami Shioya ◽  
Yume Tsukamoto ◽  
Hitomi Hasegawa ◽  
Shoei Sugita
Keyword(s):  
Plasma Cortisol ◽  
Cortisol Levels

Influence of riders’ skill on plasma cortisol levels of horses walking on forest and field trekking courses

2017 ◽  
Vol 88 (10) ◽  
pp. 1629-1635 ◽  
Author(s):  
Ayaka Ono ◽  
Akihiro Matsuura ◽  
Yumi Yamazaki ◽  
Wakako Sakai ◽  
Kentaro Watanabe ◽  
...  
Keyword(s):  
Plasma Cortisol ◽  
Cortisol Levels

Effects of different doses of eugenol on plasma cortisol levels and the quality of fresh and frozen-thawed sperm in South American catfish (Rhamdia quelen)

2019 ◽  
Vol 125 ◽  
pp. 135-139 ◽  
Author(s):  
Maira N. Corso ◽  
Lis S. Marques ◽  
Luis F.G. Gracia ◽  
Rômulo B. Rodrigues ◽  
Leonardo J.G. Barcellos ◽  
...  
Keyword(s):  
Plasma Cortisol ◽  
South American ◽  
Rhamdia Quelen ◽  
Cortisol Levels ◽  
Different Doses

Stress response of cougars to nonlethal pursuit by hunters

1992 ◽  
Vol 70 (1) ◽  
pp. 136-139 ◽  
Author(s):  
Henry J. Harlow ◽  
Frederick G. Lindzey ◽  
Walter D. Van Sickle ◽  
William A. Gern
Keyword(s):  
Stress Response ◽  
Treatment Group ◽  
Physiological Response ◽  
Plasma Cortisol ◽  
Adrenocorticotropic Hormone ◽  
The Other ◽  
Response Test ◽  
Felis Concolor ◽  
Adrenal Response ◽  
Cortisol Levels

Five cougars (Felis concolor) were captured and an adrenal response test was administered by injecting synthetic adrenocorticotropic hormone and monitoring plasma cortisol levels at 15-min intervals for 120 min. Three were selected for treatment and chased 5 or 6 more times to simulate the stress they might experience during a pursuit-only season; the other two served as controls and were chased only once more, at recapture. The adrenal response test was administered again at recapture. The cougars in the treatment group had a lowered plasma cortisol profile after the simulated pursuit season, indicating an altered physiological response of the adrenals to the stress of repeated chases.

scholarly journals Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study

2009 ◽  
Vol 161 (1) ◽  
pp. 119-130 ◽  
Author(s):  
Gudmundur Johannsson ◽  
Ragnhildur Bergthorsdottir ◽  
Anna G Nilsson ◽  
Hans Lennernas ◽  
Thomas Hedner ◽  
...  
Keyword(s):  
Single Dose ◽  
Replacement Therapy ◽  
Plasma Cortisol ◽  
Plasma Concentrations ◽  
Pharmacokinetic Studies ◽  
Double Blind ◽  
Once Daily ◽  
Physiological Serum ◽  
Cortisol Levels ◽  
Dual Release

BackgroundEndogenous plasma cortisol levels have a well-defined circadian rhythm. The aim of this project is to develop a once daily oral dual-release formulation for cortisol replacement therapy that mimics the diurnal variation in the plasma cortisol profile.ObjectiveTo determine single-dose plasma pharmacokinetics and dose-proportionality of oral 5 and 20 mg dual-release hydrocortisone tablets in healthy volunteers. In addition, the effect of food intake was investigated for the 20 mg dose.DesignA randomised, controlled, two-way cross-over, double-blind, phase I study of oral hydrocortisone (modified (dual) release; 5 and 20 mg) with an open food-interaction arm.MethodsThe single dose pharmacokinetic studies were performed with betamethasone suppression. The two first study days were blinded and randomised between morning administration of 5 and 20 mg tablet in a fasting state. The third day was open with a 20 mg tablet taken 30 min after a high-calorie, high-fat meal. The plasma samples were assayed using both a validated LC–MS/MS and an immunoassay. The plasma pharmacokinetic variables were calculated using non-compartmental data analysis.ResultsThe time to reach a clinically significant plasma concentration of cortisol (>200 nmol/l) was within 20 min and a mean peak of 431 (s.d. 126) nmol/l was obtained within 50 min after administration of the 20 mg tablet. Plasma cortisol levels remained above 200 nmol/l for around 6 h thereafter and all plasma concentrations 18–24 h after intake were below 50 nmol/l. In the fed state the time to reach 200 nmol/l was delayed by 28 and 9 min based on LC–MS/MS and immunoassay, respectively. The 5 and 20 mg tablets produced an increase in plasma exposure of cortisol that was not fully dose proportional.ConclusionThe dual release hydrocortisone tablet with once-daily administration produced a diurnal plasma cortisol profile mimicking the physiological serum cortisol profile.

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