Suppression of MyoD induces spontaneous adipogenesis in skeletal muscle progenitor cell culture

2021 ◽  
Vol 92 (1) ◽  
Author(s):  
Keitaro Yamanouchi ◽  
Katsuyuki Nakamura ◽  
Shiho Takeuchi ◽  
Tohru Hosoyama ◽  
Takashi Matsuwaki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Culture ◽  
Progenitor Cell ◽  
Muscle Progenitor Cell

TGF-β's delay skeletal muscle progenitor cell differentiation in an isoform-independent manner

2009 ◽  
Vol 315 (3) ◽  
pp. 373-384 ◽  
Author(s):  
Elske J. Schabort ◽  
Mathilde van der Merwe ◽  
Benjamin Loos ◽  
Frances P. Moore ◽  
Carola U. Niesler
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Progenitor Cell ◽  
Independent Manner ◽  
Muscle Progenitor Cell

scholarly journals Apoptosis-Inducing Factor Regulates Skeletal Muscle Progenitor Cell Number and Muscle Phenotype

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27283 ◽  
Author(s):  
Anne-Sophie Armand ◽  
Iman Laziz ◽  
Dounia Djeghloul ◽  
Sylvie Lécolle ◽  
Anne T. Bertrand ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Progenitor Cell ◽  
Cell Number ◽  
Apoptosis Inducing Factor ◽  
Muscle Progenitor Cell

scholarly journals Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics

2014 ◽  
Vol 74 ◽  
pp. 64-73 ◽  
Author(s):  
Fabrisia Ambrosio ◽  
Elke Brown ◽  
Donna Stolz ◽  
Ricardo Ferrari ◽  
Bret Goodpaster ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Progenitor Cell ◽  
Cell Ultrastructure ◽  
Muscle Progenitor Cell

scholarly journals The Impact of Age on Skeletal Muscle Progenitor Cell Survival and Fate After Injury

2017 ◽  
Vol 23 (12) ◽  
pp. 1012-1021 ◽  
Author(s):  
Yu Zhou ◽  
Daniel Lovell ◽  
Maigen Bethea ◽  
Benyam Yoseph ◽  
James Poteracki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Survival ◽  
Progenitor Cell ◽  
Muscle Progenitor Cell ◽  
The Impact

scholarly journals Correction: Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167661 ◽  
Author(s):  
Grégory Lacraz ◽  
André-Jean Rouleau ◽  
Vanessa Couture ◽  
Thomas Söllradl ◽  
Geneviève Drouin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Proliferative Activity ◽  
Progenitor Cell ◽  
Cell Proliferative Activity ◽  
Muscle Progenitor Cell

Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis

2017 ◽  
Vol 232 (10) ◽  
pp. 2653-2656 ◽  
Author(s):  
Tizhong Shan ◽  
Ziye Xu ◽  
Jiaqi Liu ◽  
Weiche Wu ◽  
Yizhen Wang
Keyword(s):  
Skeletal Muscle ◽  
Progenitor Cell ◽  
Muscle Development ◽  
Skeletal Muscle Development ◽  
Cell Homeostasis ◽  
Muscle Progenitor Cell

scholarly journals Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat

2017 ◽  
Vol 232 (3) ◽  
pp. 561-572 ◽  
Author(s):  
Ganga Gokulakrishnan ◽  
Xiaoyan Chang ◽  
Ryan Fleischmann ◽  
Marta L Fiorotto
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Progenitor Cell ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Muscle Growth ◽  
Pregnant Rats ◽  
Cross Sectional ◽  
Muscle Progenitor Cell ◽  
Fetal Muscle

Perinatal skeletal muscle growth rates are a function of protein and myonuclear accretion. Precocious exposure of the fetus to glucocorticoids (GLC) in utero impairs muscle growth. Reduced muscle protein synthesis rates contribute to this response, but the consequences for myonuclear hyperplasia are unknown. To test the hypothesis that blunting of Pax7+ muscle progenitor cell proliferative activity by GLC in vivo also contributes to reduced fetal muscle growth, pregnant rats were administered dexamethasone (DEX: 1 mg/L drinking water) from embryonic day (ED) 13 to ED21. Their responses were compared to pair-fed (PF) and ad libitum-fed controls (CON). Bromodeoxyuridine (BrdU) was administered before delivery to measure myonuclear accretion. Fetal hind limb and diaphragm muscles were collected at term and analyzed for myofiber cross-sectional area (CSA), total and BrdU+ myonuclei, Pax7+ nuclei, MyoD and myogenin protein and mRNA abundance and myosin heavy chain (MyHC) isoform composition. Mean fiber CSA, myonuclei/myofiber and Pax7+ nuclei/myofiber ratios were reduced in DEX compared to those in CON and PF muscles; CSA/myonucleus, BrdU+/total myonuclei and BrdU+ myonuclei/Pax7+ nuclei were similar among groups. Myogenin abundance was reduced and MyHC-slow was increased in DEX fetuses. The data are consistent with GLC inhibition of muscle progenitor cell proliferation limiting satellite cell and myonuclear accretion. The response of PF-fed compared to CON muscles indicated that decreased food consumption by DEX dams contributed to the smaller myofiber CSA but did not affect Pax7+ nuclear accretion. Thus, the effect on satellite cell reserve and myonuclear number also contributes to the blunting of fetal muscle growth by GLC.

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