High-level exogenoustrans10,cis12 conjugated linoleic acid plays an anti-lipogenesis role in bovine mammary epithelial cells

2014 ◽  
Vol 85 (7) ◽  
pp. 744-750 ◽  
Author(s):  
Hongfang Wang ◽  
Hongyun Liu ◽  
Jianxin Liu ◽  
Ke Zhao ◽  
Chong Wang ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Epithelial Cells ◽  
Conjugated Linoleic Acid ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Bovine Mammary Epithelial Cells ◽  
High Level

scholarly journals Conjugated linoleic acid isomers strongly improve the redox status of bovine mammary epithelial cells (BME-UV1)

2015 ◽  
Vol 98 (10) ◽  
pp. 7071-7082 ◽  
Author(s):  
L. Basiricò ◽  
P. Morera ◽  
D. Dipasquale ◽  
A. Tröscher ◽  
A. Serra ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Epithelial Cells ◽  
Conjugated Linoleic Acid ◽  
Mammary Epithelial Cells ◽  
Redox Status ◽  
Mammary Epithelial ◽  
Bovine Mammary Epithelial Cells

scholarly journals Metabolomic Profiles of Bovine Mammary Epithelial Cells Stimulated by Lipopolysaccharide

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yixin Huang ◽  
Liuhong Shen ◽  
Jing Jiang ◽  
Qipin Xu ◽  
Zhengzhong Luo ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Linoleic Acid ◽  
Epithelial Cells ◽  
High Performance ◽  
Acid Metabolism ◽  
Mammary Epithelial Cells ◽  
Phospholipid Metabolism ◽  
Mammary Epithelial ◽  
Multivariate Statistical ◽  
Bovine Mammary Epithelial Cells

AbstractBovine mammary epithelial cells (bMECs) are the main cells of the dairy cow mammary gland. In addition to their role in milk production, they are effector cells of mammary immunity. However, there is little information about changes in metabolites of bMECs when stimulated by lipopolysaccharide (LPS). This study describes a metabolomics analysis of the LPS-stimulated bMECs to provide a basis for the identification of potential diagnostic screening biomarkers and possible treatments for bovine mammary gland inflammation. In the present study, bMECs were challenged with 500 ng/mL LPS and samples were taken at 0 h, 12 h and 24 h post stimulation. Metabolic changes were investigated using high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF MS) with univariate and multivariate statistical analyses. Clustering and metabolic pathway changes were established by MetaboAnalyst. Sixty-three differential metabolites were identified, including glycerophosphocholine, glycerol-3-phosphate, L-carnitine, L-aspartate, glutathione, prostaglandin G2, α-linolenic acid and linoleic acid. They were mainly involved in eight pathways, including D-glutamine and D-glutamic acid metabolism; linoleic acid metabolism; α-linolenic metabolism; and phospholipid metabolism. The results suggest that bMECs are able to regulate pro-inflammatory, anti-inflammatory, antioxidation and energy-producing related metabolites through lipid, antioxidation and energy metabolism in response to inflammatory stimuli.

Conjugated Linoleic Acid Inhibits Proliferation and Induces Apoptosis of Normal Rat Mammary Epithelial Cells in Primary Culture

1999 ◽  
Vol 250 (1) ◽  
pp. 22-34 ◽  
Author(s):  
Margot M. Ip ◽  
Patricia A. Masso-Welch ◽  
Suzanne F. Shoemaker ◽  
Wendy K. Shea-Eaton ◽  
Clement Ip
Keyword(s):  
Linoleic Acid ◽  
Epithelial Cells ◽  
Conjugated Linoleic Acid ◽  
Primary Culture ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Normal Rat
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