Chlorogenic acid attenuates inflammation, oxidative stress, apoptosis and protects head kidney macrophage of yellow catfish from ammonia toxicity

2021 ◽  
Author(s):  
Haibo Jiang ◽  
Kewei He ◽  
Xueping Luo ◽  
Muzi Zhang ◽  
Jian Shao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chlorogenic Acid ◽  
Head Kidney ◽  
Ammonia Toxicity ◽  
Yellow Catfish

scholarly journals Quantitative Ethnomedicinal Status and Phytochemical Analysis of Berberis lyceum Royle

Agronomy ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 130
Author(s):  
Nausheen Nazir ◽  
Abdur Rahman ◽  
Faheem Uddin ◽  
Atif Ali Khan Khalil ◽  
Muhammad Zahoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chlorogenic Acid ◽  
Local Community ◽  
Antioxidant Activities ◽  
Local Communities ◽  
Antioxidant Potential ◽  
Phytochemical Analysis ◽  
Therapeutic Effects ◽  
Use Value ◽  
Phytochemical Composition

Berberis lyceum Royle has such pronounced medicinal values that it is used as cure of many diseases and has exhibited great therapeutic effects among the local communities throughout the world. The present research was carried out to evaluate the quantitative ethnobotanical status and phytochemical analysis of B. lyceum. Regular field trips were arranged to the study area (Shangla District) in August 2017 to October 2019 and interviews with 100 residents (age range: 30 to 50 years) were conducted. The approach adopted for ethnobotanical data was semi-scientific as the inhabitants were not aware about the modern names of some diseases and therefore physician prescriptions were also consulted. Ethnobotanical data were examined using relative frequency of citation and % use value. The % use value of B. lyceum indicates that the people of District Shangla mostly used it for curing of different diseases. In spite of tremendous uses the plant still survived in this area mainly due to the non-accessibility for humans of the mountain tops; otherwise, increase in anthropogenic activities even in these hilly areas poses a threat of the eradication of this plant. To correlate the folkloric uses with its phytochemical composition, HPLC (high performance liquid chromatography) analysis was performed and a total of six phenolic compounds (quercetin, chlorogenic acid, berberine, rutin, mandellic acid, and hydroxy benzoic acid) were identified in its root. As most of the health complications are correlated to oxidative stress therefore in vitro antioxidant activity were also performed using DPPH (2, 2- diphenyl-1-picrylhydrazyl) and ABTS (2, 2′-azinobis-3-ethyl benzo thiazoline -6- sulfonic acid) assays. The observed antioxidant potential may most probably be due to berberine and chlorogenic acid that were present in highest concentration in the analyzed extract. The effectiveness of the selected plant as remedy for a number of diseases (that were pointed out by the local community) may be due to its phytochemical composition especially berberine and chlorogenic acid as oxidative stress is the root cause of many diseases. The plant extract exhibited high antioxidant potential (DPPH IC50 = 165µg/mL; ABTSIC50 = 110µg/mL) in relation to the detected concentration of berberine and chlorogenic acid. It can be inferred from experimental results that the ethnopharmacological efficacy of this endangered species may be due to its phytochemical composition and antioxidant activities. This case study helps to revive the importance of B. lyceum in local communities and emphasizes the need for its conservation.

Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis

2019 ◽  
Vol 47 (2) ◽  
pp. 1161-1171 ◽  
Author(s):  
Mohamed A. Dkhil ◽  
Ahmed E. Abdel Moneim ◽  
Amira A. Bauomy ◽  
Mona Khalil ◽  
Esam M. Al-Shaebi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chlorogenic Acid

scholarly journals Experimental Pretreatment with Chlorogenic Acid Prevents Transient Ischemia-Induced Cognitive Decline and Neuronal Damage in the Hippocampus through Anti-Oxidative and Anti-Inflammatory Effects

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3578 ◽  
Author(s):  
Tae-Kyeong Lee ◽  
Il-Jun Kang ◽  
Bora Kim ◽  
Hye Jin Sim ◽  
Dae- Won Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Chlorogenic Acid ◽  
Western Blotting ◽  
Inflammatory Cytokines ◽  
Ischemia Reperfusion ◽  
Forebrain Ischemia ◽  
Transient Forebrain Ischemia ◽  
Fluoro Jade B ◽  
Anti Inflammatory

Chlorogenic acid (CGA), an ester of caffeic acid and quinic acid, is among the phenolic acid compounds which can be naturally found in green coffee extract and tea. CGA has been studied since it displays significant pharmacological properties. The aim of this study was to investigate the effects of CGA on cognitive function and neuroprotection including its mechanisms in the hippocampus following transient forebrain ischemia in gerbils. Memory and learning following the ischemia was investigated by eight-arm radial maze and passive avoidance tests. Neuroprotection was examined by immunohistochemistry for neuronal nuclei-specific protein and Fluoro-Jade B histofluorescence staining. For mechanisms of the neuroprotection, alterations in copper, zinc-superoxide dismutase (SOD1), SOD2 as antioxidant enzymes, dihydroethidium and 4-hydroxy-2-nonenal as indicators for oxidative stress, and anti-inflammatory cytokines (interleukin (IL)-4 and IL-13) and pro-inflammatory cytokines (tumor necrosis factor α (TNF-α) and IL-2) were examined by Western blotting and/or immunohistochemistry. As a result, pretreatment with 30 mg/kg CGA attenuated cognitive impairment and displayed a neuroprotective effect against transient forebrain ischemia (TFI). In Western blotting, the expression levels of SOD2 and IL-4 were increased due to pretreatment with CGA and, furthermore, 4-HNE production and IL-4 expressions were inhibited by CGA pretreatment. Additionally, pretreated CGA enhanced antioxidant enzymes and anti-inflammatory cytokines and, in contrast, attenuated oxidative stress and pro-inflammatory cytokine expression. Based on these results, we suggest that CGA can be a useful neuroprotective material against ischemia-reperfusion injury due to its antioxidant and anti-inflammatory efficacies.

scholarly journals Protective Effects of Chlorogenic Acid on Paraquat-induced Oxidative Stress in Rats

1996 ◽  
Vol 60 (5) ◽  
pp. 765-768 ◽  
Author(s):  
Tomofumi Tsuchiya ◽  
Orie Suzuki ◽  
Kiharu Igarashi
Keyword(s):  
Oxidative Stress ◽  
Chlorogenic Acid ◽  
Protective Effects
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