Untargeted LC–MS metabolomics approach reveals metabolic changes in genetically improved farmed tilapia ( Oreochromis niloticus ) with fatty liver induced by a high‐fat diet

2020 ◽  
Author(s):  
Yi‐Fan Tao ◽  
Jun Qiang ◽  
Jie He ◽  
Hao‐Jun Zhu ◽  
Jing‐Wen Bao ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Oreochromis Niloticus ◽  
High Fat Diet ◽  
Metabolic Changes ◽  
High Fat ◽  
Genetically Improved

scholarly journals Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takuya Kawamura ◽  
Hiroaki Tanaka ◽  
Ryota Tachibana ◽  
Kento Yoshikawa ◽  
Shintaro Maki ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fetal Growth ◽  
Fetal Programming ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Control Group ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

AbstractWe aimed to investigate the effects of maternal tadalafil therapy on fetal programming of metabolic function in a mouse model of fetal growth restriction (FGR). Pregnant C57BL6 mice were divided into the control, L-NG-nitroarginine methyl ester (L-NAME), and tadalafil + L-NAME groups. Six weeks after birth, the male pups in each group were given a high-fat diet. A glucose tolerance test (GTT) was performed at 15 weeks and the pups were euthanized at 20 weeks. We then assessed the histological changes in the liver and adipose tissue, and the adipocytokine production. We found that the non-alcoholic fatty liver disease activity score was higher in the L-NAME group than in the control group (p < 0.05). Although the M1 macrophage numbers were significantly higher in the L-NAME/high-fat diet group (p < 0.001), maternal tadalafil administration prevented this change. Moreover, the epididymal adipocyte size was significantly larger in the L-NAME group than in the control group. This was also improved by maternal tadalafil administration (p < 0.05). Further, we found that resistin levels were significantly lower in the L-NAME group compared to the control group (p < 0.05). The combination of exposure to maternal L-NAME and a high-fat diet induced glucose impairment and non-alcoholic fatty liver disease. However, maternal tadalafil administration prevented these complications. Thus, deleterious fetal programming caused by FGR might be modified by in utero intervention with tadalafil.

Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress

2021 ◽  
pp. 2100417
Author(s):  
Yangmian Yuan ◽  
Chengyu Liu ◽  
Xingrui Chen ◽  
Yuyan Sun ◽  
Mingrui Xiong ◽  
...  
Keyword(s):  
Vitamin C ◽  
High Fat Diet ◽  
Metabolic Changes ◽  
High Fat

The beneficial effects of Lactobacillus fermented black barley on high fat diet-induced fatty liver in rats

2021 ◽  
Author(s):  
Qi Guan ◽  
Xinwen Ding ◽  
Lingyue Zhong ◽  
Chuang Zhu ◽  
Pan Nie ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Beneficial Effects ◽  
Phytochemical Composition

Long term high-fat diet (HF) can cause metabolic disorders, which might induce fatty liver. Fermented whole cereal food exhibit healthy potential due to their unique phytochemical composition and probiotics. In...

scholarly journals Bitter Gourd Inhibits the Development of Obesity-Associated Fatty Liver in C57BL/6 Mice Fed a High-Fat Diet

2014 ◽  
Vol 144 (4) ◽  
pp. 475-483 ◽  
Author(s):  
Jie Xu ◽  
Ke Cao ◽  
Yuan Li ◽  
Xuan Zou ◽  
Cong Chen ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Bitter Gourd ◽  
High Fat
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