Effect of combination of dietary Bacillus subtilis and trans ‐cinnamic acid on innate immune responses and resistance of rainbow trout, Oncorhynchus mykiss to Yersinia ruckeri

2019 ◽  
Vol 51 (2) ◽  
pp. 441-454 ◽  
Author(s):  
Sevdan Yılmaz ◽  
Sebahattin Ergun ◽  
Murat Yigit ◽  
Ekrem Şanver Çelik
Keyword(s):  
Bacillus Subtilis ◽  
Rainbow Trout ◽  
Immune Responses ◽  
Oncorhynchus Mykiss ◽  
Cinnamic Acid ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Yersinia Ruckeri ◽  
Rainbow Trout Oncorhynchus Mykiss

scholarly journals Innate and early immune responses to Yersinia ruckeri in the spleen of rainbow trout (Oncorhynchus mykiss)

2021 ◽  
Author(s):  
Di Wang ◽  
Simeng Sun ◽  
Shaowu Li ◽  
Tongyan Lu ◽  
Dongfang Shi
Keyword(s):  
Rainbow Trout ◽  
Immune Responses ◽  
Oncorhynchus Mykiss ◽  
Mapk Signaling ◽  
Receptor Interaction ◽  
Receptor Signaling ◽  
Yersinia Ruckeri ◽  
Immunological Responses ◽  
Kegg Pathways ◽  
Rainbow Trout Oncorhynchus Mykiss

Abstract Background: Yersinia ruckeri is a pathogen that can cause enteric redmouth disease in salmonid species, damaging global production of economically important fish including rainbow trout (Oncorhynchus mykiss). Herein, we conducted the transcriptomic profiling of spleen samples from rainbow trout at 24 h post-Y. ruckeri infection via RNA-seq in an effort to more fully understand their immunological responses. Results: We identified 2498 differentially expressed genes (DEGs), of which 2083 and 415 were up- and down-regulated, respectively. We then conducted a more in-depth assessment of 78 DEGs associated with the immune system including CCR9, CXCL11, IL-1β, CARD9, IFN, CASP8, NF-κB, NOD1, TLR8α2, HSP90, and MAPK11, revealing these genes to be associated with 20 different immunological KEGG pathways including the Cytokine-cytokine receptor interaction, Toll-like receptor signaling, RIG-I-like receptor signaling, NOD-like receptor signaling, and MAPK signaling pathways. Additionally, the differential expression of 8 of these DEGs was validated by a qPCR approach and their immunological importance was then discussed. Conclusions: Our findings provide preliminary insight regarding the innate and early immune responses of rainbow trout following Y. ruckeri infection and the base for future studies of host-pathogen interactions in rainbow trout.

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