Effects of dietary α-ketoglutarate supplementation on the antioxidant defense system and HSP 70 and HSP 90 gene expression of hybrid sturgeonAcipenser schrenckii ♀ × A. baerii ♂exposed to ammonia-N stress

2016 ◽  
Vol 48 (5) ◽  
pp. 2266-2277 ◽  
Author(s):  
Liansheng Wang ◽  
Qiyou Xu ◽  
Chang'an Wang ◽  
Jinnan Li ◽  
Di Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Hsp 70 ◽  
Hsp 90

Effect of a Prolonged Dietary Iron Intake on the Gene Expression and Activity of the Testicular Antioxidant Defense System in Rats

2019 ◽  
Vol 195 (1) ◽  
pp. 135-141 ◽  
Author(s):  
Enver Fehim Kocpinar ◽  
Nurdan Gonul Baltaci ◽  
Hamid Ceylan ◽  
Seyda Nur Kalin ◽  
Orhan Erdogan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Dietary Iron ◽  
Iron Intake ◽  
Defense System ◽  
Expression And Activity

scholarly journals Genotype-dependent gene expression profile of the antioxidant defense system (ADS) in the liver of a GH-transgenic zebrafish model

2010 ◽  
Vol 20 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Carlos E. da Rosa ◽  
Márcio A. Figueiredo ◽  
Carlos F. C. Lanes ◽  
Daniela V. Almeida ◽  
Luis F. Marins
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Transgenic Zebrafish ◽  
Defense System ◽  
Zebrafish Model

scholarly journals NR4A3 is oxidative stress responsible transcription factor through HMOX1, and also controls cell cycle through CCNE1 and CDK2 in pancreatic islet derived 1.1B4 cells

2021 ◽  
Author(s):  
Motoko Nakayama ◽  
Etsuko Ueta ◽  
Mitsuru Yoshida ◽  
Yuri Shimizu ◽  
Reiko Oguchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Transcription Factor ◽  
Pancreatic Islet ◽  
Growth Regulation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Orphan Receptor ◽  
Defense System ◽  
Oxidative Condition

The mechanism of antioxidant defense system is still controversial. As islet β-cell is weak in oxidative condition, that causes diabetes mellitus, therefore, antioxidant defense system of human pancreatic islet derived 1.1B4 cell was analyzed. Cells were exposed to H2O2 and comprehensive gene expression was analyzed by Agilent human microarray. HMOX1 and NR4A3, member of orphan receptor, were up-regulated. Therefore, NR4A3 was knocked down with siRNA, then analyzed gene expression by microarray, and found that the knocked down cells were weak in oxidative stress. HMOX1 expression was strongly inhibited by siRNA of NR4A3, and NR4A3 responsible sequence of aaggtca was found near the HMOX1 gene, suggesting NR4A3 is oxidative stress responsible transcription factor through HMOX1 expression. The expression of CCNE1 and CDK2 was also inhibited by knocked down of NR4A3, it is suggested NR4A3 is also important transcription factor for cell growth regulation.

Impact of fluoride and a static magnetic field on the gene expression that is associated with the antioxidant defense system of human fibroblasts

2018 ◽  
Vol 287 ◽  
pp. 13-19 ◽  
Author(s):  
Magdalena Kimsa-Dudek ◽  
Agnieszka Synowiec-Wojtarowicz ◽  
Małgorzata Derewniuk ◽  
Stanisław Gawron ◽  
Monika Paul-Samojedny ◽  
...  
Keyword(s):  
Gene Expression ◽  
Magnetic Field ◽  
Static Magnetic Field ◽  
Antioxidant Defense ◽  
Human Fibroblasts ◽  
Antioxidant Defense System ◽  
Defense System

scholarly journals Effects of increased concentrations of chloride on the expression of Mn-SOD enzyme in tobacco

2017 ◽  
Vol 109 (1) ◽  
pp. 53
Author(s):  
Akbar Norastehnia ◽  
Parvaneh SHEYDAEI
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Manganese Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Antioxidant Response ◽  
Defense System ◽  
Reverse Transcription Pcr ◽  
Manganese Superoxide ◽  
System Activation

<p>Chlorine is one of the ions contributing to salinity, despite being an essential micronutrient. Cl<sup>-</sup> absorption takes place more easily than other nutrients so, the toxic effects of chlorine on the growth has considered rather than its scarcity. Salt stress can ultimately leads to oxidative stress through ROS increase and antioxidant defense system is induced. Therefore, in this study the effect of different concentration of chlorine in irrigation water on the expression of manganese superoxide dismutase was investigated as an indicator of antioxidant defense system activation. Seedlings of tobacco were treated with different concentrations, i.e. 2, 4, 8 mM of CaCl<sub>2</sub>. Evaluation of Mn-SOD isoenzyme gene expression was performed using RT-qPCR (quantitative reverse transcription PCR) at 0, 3, 6 and 12 hours after treatment. The results showed Mn-SOD gene transcription increased after 3 h treatment with 8 mM CaCl<sub>2</sub> and peaked at 6 hours. Based on the observed changes, concentrations of calcium chloride greater than 8 mM in water used for irrigation of tobacco causes stress that results in activation of antioxidant response.</p>

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