Long‐term prognosis of patients with metabolic (dysfunction)‐associated fatty liver disease by non‐invasive methods

2022 ◽  
Author(s):  
Marie Decraecker ◽  
Dan Dutartre ◽  
Jean‐Baptiste Hiriart ◽  
Marie Irles‐Depé ◽  
Faiza Chermak ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Dysfunction ◽  
Non Invasive ◽  
Long Term Prognosis

scholarly journals The Role of the Gut-Liver Axis in Metabolic Dysfunction-Associated Fatty Liver Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Rosa Martín-Mateos ◽  
Agustín Albillos
Keyword(s):  
Immune System ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Structural Changes ◽  
Intestinal Flora ◽  
Intestinal Barrier ◽  
Intercellular Junctions ◽  
Metabolic Dysfunction ◽  
Non Invasive

The complex interplay between the gut microbiota, the intestinal barrier, the immune system and the liver is strongly influenced by environmental and genetic factors that can disrupt the homeostasis leading to disease. Among the modulable factors, diet has been identified as a key regulator of microbiota composition in patients with metabolic syndrome and related diseases, including the metabolic dysfunction-associated fatty liver disease (MAFLD). The altered microbiota disrupts the intestinal barrier at different levels inducing functional and structural changes at the mucus lining, the intercellular junctions on the epithelial layer, or at the recently characterized vascular barrier. Barrier disruption leads to an increased gut permeability to bacteria and derived products which challenge the immune system and promote inflammation. All these alterations contribute to the pathogenesis of MAFLD, and thus, therapeutic approaches targeting the gut-liver-axis are increasingly being explored. In addition, the specific changes induced in the intestinal flora may allow to characterize distinctive microbial signatures for non-invasive diagnosis, severity stratification and disease monitoring.

379 Characteristics and Long-Term Prognosis of Lean Patients With Nonalcoholic Fatty Liver Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-909 ◽  
Author(s):  
Anna Christina Dela Cruz ◽  
Elisabetta Bugianesi ◽  
Jacob George ◽  
Christopher P. Day ◽  
Hammad Liaquat ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Long Term Prognosis

scholarly journals Ultrasound Elastography—Cornerstone of Non-Invasive Metabolic Dysfunction-Associated Fatty Liver Disease Assessment

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 516
Author(s):  
Andrej Hari
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Ultrasound Elastography ◽  
Disease Assessment ◽  
Metabolic Dysfunction ◽  
Common Cause ◽  
Non Invasive ◽  
Invasive Evaluation

Metabolic dysfunction-associated fatty liver disease has become the most common chronic liver disease as well as the most common cause for liver transplantation. With its different methods types, elastography of the liver can be used for non-invasive evaluation of the liver fibrosis and steatosis degree. The article focuses on the description, use, advantages, and limitations of the currently known elastographic techniques. It proposes a simple risk assessment algorithm for the liver fibrosis progress evaluation. The following is an overview of the use of liver and spleen elastography in the detection of clinically relevant portal hypertension. It concludes with research and technological possibilities that could be important to the field in the upcoming years.

Simple Non Invasive Fibrosis Scores Predict Long Term Mortality in Patients with Non Alcoholic Fatty Liver Disease

2016 ◽  
Vol 64 (2) ◽  
pp. S720-S721
Author(s):  
E. Buzzetti ◽  
R. Manguerra ◽  
A. Hall ◽  
L. De Luca ◽  
P. Manousou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease ◽  
Long Term Mortality

Sa1047 Increased Hepatic Iron Deposition and Long-Term Prognosis of Patients With Nonalcoholic Fatty Liver Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-946
Author(s):  
Wesam M. Frandah ◽  
David E. Kleiner ◽  
Sanne Dam-Larsen ◽  
Svanhildur Haflidadottir ◽  
Phunchai Charatcharoenwitthaya ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Long Term Prognosis
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