Large-scale genome-wide association study identifies HLA class II variants associated with chronic HBV infection: a study from Taiwan Biobank

2020 ◽  
Vol 52 (4) ◽  
pp. 682-691 ◽  
Author(s):  
Yu-Han Huang ◽  
Shu-Fen Liao ◽  
Seik-Soon Khor ◽  
Yu-Ju Lin ◽  
Hsuan-Yu Chen ◽  
...  
Keyword(s):  
Association Study ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hbv Infection ◽  
Genome Wide Association ◽  
Chronic Hbv Infection ◽  
Genome Wide ◽  
Chronic Hbv

scholarly journals A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han-Taiwanese

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99724 ◽  
Author(s):  
Su-Wei Chang ◽  
Cathy Shen-Jang Fann ◽  
Wen-Hui Su ◽  
Yu Chen Wang ◽  
Chia Chan Weng ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Hbv Infection ◽  
Genome Wide Association ◽  
Clinical Progression ◽  
Chronic Hbv Infection ◽  
Genome Wide ◽  
A Genome ◽  
Chronic Hbv

scholarly journals Erratum: Corrigendum: Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

2011 ◽  
Vol 43 (4) ◽  
pp. 388-388
Author(s):  
Hyun Hor ◽  
Zoltán Kutalik ◽  
Yves Dauvilliers ◽  
Armand Valsesia ◽  
Gert J Lammers ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9723 ◽  
Author(s):  
Masahiro Nakajima ◽  
Atsushi Takahashi ◽  
Ikuyo Kou ◽  
Cristina Rodriguez-Fontenla ◽  
Juan J. Gomez-Reino ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Genome Wide Association ◽  
Sequence Variants ◽  
Genome Wide

scholarly journals Genome-wide association study of TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and hepatitis B virus infection in Guangxi

2020 ◽  
Author(s):  
Chuangye Han ◽  
Tingdong Yu ◽  
Wei Qin ◽  
Xiwen Liao ◽  
Jianlu Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Tumor Tissue ◽  
Genome Wide Association Study ◽  
Hbv Infection ◽  
Genome Wide Association ◽  
Chronic Hbv Infection ◽  
Genome Wide ◽  
B Virus ◽  
Chronic Hbv

AbstractBackground/AimsDietary aflatoxin B1 (AFB1) exposure, which induces DNA damage and codon 249 mutation of the TP53 gene, is one of the major risk factors for hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) infection and AFB1 exert synergistic effects to promote carcinogenesis and TP53 R249S mutation in HCC.MethodsA genome-wide association study (GWAS) was conducted on 485 cases of HCC with chronic HBV infection, followed by a two-stage replication study on 270 cases with chronic HBV infection. Susceptibility variants for the TP53 R249S mutation in HCC were identified based on both GWAS and replication analysis. The associations of identified variants with expression levels of their located genes were validated in 20 paired independent samples.ResultsOur results showed that TP53 R249S was significantly associated with ADAMTS18 rs9930984 (adjusted P = 4.84×10−6), WDR49 rs75218075 (adjusted P = 7.36 × 10−5) and SLC8A3 rs8022091 (adjusted P = 0.042). Additionally, ADAMTS18 mRNA expression was significantly higher in HCC tissue, compared with paired non-tumor tissue (P = 0.041) and patients carrying the TT genotype at rs9930984 showed lower ADAMTS18 expression in non-tumor tissue, compared with those carrying the GT genotype (P = 0.0028).ConclusionsTP53 expression is significantly associated with R249S mutation in HCC. Our collective results suggest that rs9930984, rs75218075 and rs8022091 are associated with susceptibility to the R249S mutation in cases of HCC exposed to AFB1 and HBV infection.

scholarly journals A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raquel López-Mejías ◽  
F. David Carmona ◽  
Santos Castañeda ◽  
Fernanda Genre ◽  
Sara Remuzgo-Martínez ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Iga Vasculitis ◽  
Genome Wide ◽  
A Genome

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

2010 ◽  
Vol 42 (9) ◽  
pp. 786-789 ◽  
Author(s):  
Hyun Hor ◽  
Zoltán Kutalik ◽  
Yves Dauvilliers ◽  
Armand Valsesia ◽  
Gert J Lammers ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Class Ii ◽  
Hla Class Ii ◽  
Genome Wide Association ◽  
Genome Wide
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