scholarly journals Letter: off-label use of hyperbaric oxygen therapy in inflammatory bowel disease-Authors’ reply

2020 ◽  
Vol 52 (1) ◽  
pp. 216-217
Author(s):  
Melek Simsek ◽  
Nanne K. H. de Boer
Keyword(s):  
Inflammatory Bowel Disease ◽  
Hyperbaric Oxygen ◽  
Bowel Disease ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Off Label Use ◽  
Off Label ◽  
Inflammatory Bowel ◽  
Label Use

scholarly journals Letter: off-label use of hyperbaric oxygen therapy in inflammatory bowel disease

2020 ◽  
Vol 52 (1) ◽  
pp. 215-216 ◽  
Author(s):  
Corine A. Lansdorp ◽  
Christianne J. Buskens ◽  
Krisztina B. Gecse ◽  
Geert R. A. M. D’Haens ◽  
Rob A. van Hulst
Keyword(s):  
Inflammatory Bowel Disease ◽  
Hyperbaric Oxygen ◽  
Bowel Disease ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Off Label Use ◽  
Off Label ◽  
Inflammatory Bowel ◽  
Label Use

Hyperbaric oxygen therapy in inflammatory bowel disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Anupam Kumar Singh ◽  
Daya Krishna Jha ◽  
Anuraag Jena ◽  
Praveen Kumar-M ◽  
Shaji Sebastian ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Hyperbaric Oxygen ◽  
Bowel Disease ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Inflammatory Bowel

P-135 Hyperbaric Oxygen Therapy for the Treatment of Inflammatory Bowel Disease

2013 ◽  
Vol 19 ◽  
pp. S77-S78
Author(s):  
Parambir Dulai ◽  
Michael Gleeson ◽  
Dean Taylor ◽  
Jay Buckey ◽  
Siegel Corey
Keyword(s):  
Inflammatory Bowel Disease ◽  
Hyperbaric Oxygen ◽  
Bowel Disease ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Inflammatory Bowel

scholarly journals Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease

2014 ◽  
Vol 39 (11) ◽  
pp. 1266-1275 ◽  
Author(s):  
P. S. Dulai ◽  
M. W. Gleeson ◽  
D. Taylor ◽  
S. D. Holubar ◽  
J. C. Buckey ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Hyperbaric Oxygen ◽  
Bowel Disease ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Safety And Efficacy ◽  
Inflammatory Bowel

The Effectiveness and Safety of Hyperbaric Oxygen Therapy in Various Phenotypes of Inflammatory Bowel Disease: Systematic Review With Meta-analysis

2021 ◽  
Author(s):  
Jeffrey McCurdy ◽  
Kevin Chin Koon Siw ◽  
Rana Kandel ◽  
Sarah Larrigan ◽  
Greg Rosenfeld ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Study Quality ◽  
Randomized Controlled ◽  
Inflammatory Bowel

Abstract Background Accumulating evidence suggests that hyperbaric oxygen therapy (HBOT) may be effective for inflammatory bowel disease (IBD). Our systematic review aimed to quantify the effectiveness and safety of HBOT in various IBD phenotypes. Methods We performed a proportional meta-analysis. Multiple databases were systematically searched from inception through November 2020 without language restriction. We included studies that reported effectiveness and/or safety of HBOT in IBD. Weighted summary estimates with 95% confidence intervals (Cis) were calculated for clinical outcomes for each IBD phenotype using random-effects models. Study quality was assessed using the Cochrane evaluation handbook and National Institute of Health criteria. Results Nineteen studies with 809 patients total were eligible: 3 randomized controlled trials and 16 case series. Rates of clinical remission included 87% (95% CI, 10–100) for ulcerative colitis (n = 42), 88% (95% CI, 46–98) for luminal Crohn’s disease (CD, n = 8), 60% (95% CI, 40–76) for perianal CD (n = 102), 31% (95% CI, 16–50) for pouch disorders (n = 60), 92% (95% CI, 38–100) for pyoderma gangrenosum (n = 5), and 65% (95% CI, 10–97) for perianal sinus/metastatic CD (n = 7). Of the 12 studies that reported on safety, 15% of patients (n = 30) had minor adverse events. Study quality was low in the majority of studies due to an absence of comparator arms, inadequate description of concomitant interventions, and/or lack of objective outcomes. Conclusions Limited high-quality evidence suggests that HBOT is safe and associated with substantial rates of clinical remission for multiple IBD phenotypes. Well-designed randomized controlled trials are warranted to confirm the benefit of HBOT in IBD.

P702 Off-label drug use in patients with inflammatory bowel disease: a national survey among tertiary care centres

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S472-S472
Author(s):  
M Simsek ◽  
F Hoentjen ◽  
B Oldenburg ◽  
C Y Ponsioen ◽  
J van der Woude ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Drug Use ◽  
National Survey ◽  
Bowel Disease ◽  
Tertiary Care ◽  
Off Label ◽  
Inflammatory Bowel

scholarly journals Hyperbaric oxygen: a novel modality to ameliorate experimental colitis

Gut ◽  
1998 ◽  
Vol 43 (4) ◽  
pp. 512-518 ◽  
Author(s):  
D Rachmilewitz ◽  
F Karmeli ◽  
E Okon ◽  
I Rubenstein ◽  
O S Better
Keyword(s):  
Inflammatory Bowel Disease ◽  
Acetic Acid ◽  
Hyperbaric Oxygen ◽  
Bowel Disease ◽  
Experimental Colitis ◽  
Prostaglandin E ◽  
Therapeutic Effects ◽  
Once Daily ◽  
Inflammatory Bowel

Background—Hyperbaric oxygen (HBO) has been suggested to be beneficial in inflammatory bowel disease but the mechanisms responsible for its therapeutic effects have not been elucidated.Aim—To assess the effect of HBO treatment on colonic damage in two models of experimental colitis, and to examine whether this effect is mediated by modulation of NO synthesis.Methods—Colitis was induced by either flushing the colon with 2 ml 5% acetic acid or intracolonic administration of 30 mg trinitrobenzenesulphonic acid (TNB) dissolved in 0.25 ml 50% ethanol. Rats were exposed to HBO (100% oxygen at 2.4 atmosphere absolute) for one hour twice on the day of colitis induction and once daily thereafter. Control rats were treated only with acetic acid or TNB. Rats were killed 24 hours after acetic acid administration or one and seven days after TNB treatment. The colon was isolated, washed, and weighed, the lesion area was measured, and mucosal scrapings were processed for determination of myeloperoxidase (MPO) and NO synthase (NOS) activities, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) generation.Results—In control rats exposed for seven days to HBO, colonic NOS activity was significantly decreased by 61%, compared with its activity in untreated rats (2.93 (0.17) nmol/g/min). HBO significantly reduced by 51 and 62% the extent of injury induced by acetic acid and TNB respectively. The protection provided by HBO was accompanied by a significant decrease in colonic weight, PGE2 generation, MPO, and NOS activities. In acetic acid colitis, LTB4 generation was also significantly decreased.Conclusions—(1) HBO effectively decreases colitis induced by acetic acid and TNB. (2) The decreased NOS activity induced by HBO suggests that reduction in NO generation may be among the mechanisms responsible for the anti-inflammatory effect of HBO. (3) HBO may be considered in the treatment of patients with refractory inflammatory bowel disease.

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