Risk of de-novo inflammatory bowel disease among obese patients treated with bariatric surgery or weight loss medications

2020 ◽  
Vol 51 (11) ◽  
pp. 1067-1075 ◽  
Author(s):  
Gursimran S. Kochhar ◽  
Aakash Desai ◽  
Aslam Syed ◽  
Abhinav Grover ◽  
Sandra El Hachem ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Bowel Disease ◽  
De Novo ◽  
Obese Patients ◽  
Inflammatory Bowel ◽  
Weight Loss Medications

Bariatric Surgery in Patients With Inflammatory Bowel Disease: A Case-Control Study from the GETAID

2021 ◽  
Author(s):  
Catherine Reenaers ◽  
Arnaud de Roover ◽  
Laurent Kohnen ◽  
Maria Nachury ◽  
Marion Simon ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Bowel Disease ◽  
Small Sample ◽  
Control Group ◽  
Prevalence Of Obesity ◽  
History Of ◽  
Inflammatory Bowel ◽  
Small Sample Sizes

Abstract Background The prevalence of obesity and the number of bariatric surgeries in both the general population and in patients with inflammatory bowel disease (IBD) have increased significantly in recent years. Due to small sample sizes and the lack of adequate controls, no definite conclusions can be drawn from the available studies on the safety and efficacy of bariatric surgery (BS) in patients with IBD. Our aim was to assess safety, weight loss, and deficiencies in patients with IBD and obesity who underwent BS and compare findings to a control group. Methods Patients with IBD and a history of BS were retrospectively recruited to centers belonging to the Groupe d’Etude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID). Patients were matched 1:2 for age, sex, body mass index (BMI), hospital of surgery, and type of BS with non-IBD patients who underwent BS. Complications, rehospitalizations, weight, and deficiencies after BS were collected in cases and controls. Results We included 88 procedures in 85 patients (64 Crohn’s disease, 20 ulcerative colitis, 1 unclassified IBD) with a mean BMI of 41.6 ± 5.9 kg/m2. Bariatric surgery included Roux-en-Y gastric bypass (n = 3), sleeve gastrectomy (n = 73), and gastric banding (n = 12). Eight (9%) complications were reported, including 4 (5%) requiring surgery. At a mean follow-up of 34 months, mean weight was 88.6 ± 22.4 kg. No difference was observed between cases and controls for postoperative complications (P = .31), proportion of weight loss (P = .27), or postoperative deficiencies (P = .99). Conclusions Bariatric surgery is a safe and effective procedure in patients with IBD and obesity; outcomes in this patient group were similar to those observed in a control population.

scholarly journals P263 De-novo inflammatory bowel disease after bariatric surgery: a novel association

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S211-S211 ◽  
Author(s):  
M.B. Braga Neto ◽  
E. Loftus ◽  
D. Bruining ◽  
F. Bazerbachi ◽  
B. Abu Dayyeh ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
De Novo ◽  
Novel Association ◽  
Inflammatory Bowel

Bariatric surgery in morbidly obese patients with inflammatory bowel disease: A systematic review

2017 ◽  
Vol 13 (4) ◽  
pp. 652-659 ◽  
Author(s):  
Saeed Shoar ◽  
Sayed Shahabuddin Hoseini ◽  
Mohammad Naderan ◽  
Habibollah Mahmoodzadeh ◽  
Fung Ying Man ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Inflammatory Bowel

scholarly journals De-novo Inflammatory Bowel Disease After Bariatric Surgery: A Large Case Series

2017 ◽  
Vol 12 (4) ◽  
pp. 452-457 ◽  
Author(s):  
Manuel B Braga Neto ◽  
Martin Gregory ◽  
Guilherme P Ramos ◽  
Edward V Loftus ◽  
Matthew A Ciorba ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
De Novo ◽  
Case Series ◽  
Large Case Series ◽  
Inflammatory Bowel ◽  
Large Case

scholarly journals Impact of Bariatric Surgery on the Long-term Disease Course of Inflammatory Bowel Disease

2019 ◽  
Vol 26 (7) ◽  
pp. 1089-1097 ◽  
Author(s):  
Manuel B Braga Neto ◽  
Martin H Gregory ◽  
Guilherme P Ramos ◽  
Fateh Bazerbachi ◽  
David H Bruining ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
A Prospective Study ◽  
Prospective Study Design ◽  
The Impact

Abstract Background An association between inflammatory bowel disease (IBD) and obesity has been observed. Little is known about the effect of weight loss on IBD course. Our aim was to determine the impact of bariatric surgery on long-term clinical course of obese patients with IBD, either Crohn's disease (CD) or ulcerative colitis (UC). Methods Patients with IBD who underwent bariatric surgery subsequent to IBD diagnosis were identified from 2 tertiary IBD centers. Complications after bariatric surgery were recorded. Patients were matched 1:1 for age, sex, IBD subtype, phenotype, and location to patients with IBD who did not undergo bariatric surgery. Controls started follow-up at a time point in their disease similar to the disease duration in the matched case at the time of bariatric surgery. Inflammatory bowel disease medication usage and disease-related complications (need for corticosteroids, hospitalizations, and surgeries) among cases and controls were compared. Results Forty-seven patients met inclusion criteria. Appropriate matches were found for 25 cases. Median follow-up among cases (after bariatric surgery) and controls was 7.69 and 7.89 years, respectively. Median decrease in body mass index after bariatric surgery was 12.2. Rescue corticosteroid usage and IBD-related surgeries were numerically less common in cases than controls (24% vs 52%; odds ratio [OR], 0.36; 95% confidence interval [CI], 0.08–1.23; 12% vs 28%; OR, 0.2; 95% CI, 0.004–1.79). Two cases and 1 control were able to discontinue biologics during follow-up. Conclusions Inflammatory bowel disease patients with weight loss after bariatric surgery had fewer IBD-related complications compared with matched controls. This observation requires validation in a prospective study design.

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