Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

2019 ◽  
Vol 50 (11-12) ◽  
pp. 1146-1158 ◽  
Author(s):  
John Gubatan ◽  
Naomi D. Chou ◽  
Ole Haagen Nielsen ◽  
Alan C. Moss
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Clinical Outcomes ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Adult Patients ◽  
Vitamin D Status ◽  
Inflammatory Bowel

Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 32 (6) ◽  
pp. 508-518
Author(s):  
Shanzhen Shi ◽  
◽  
Jiaxing Feng ◽  
Lixiang Zhou ◽  
Yu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

scholarly journals Side Effects Associated with Probiotic Use in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2913 ◽  
Author(s):  
Maria Pina Dore ◽  
Stefano Bibbò ◽  
Gianni Fresi ◽  
Gabrio Bassotti ◽  
Giovanni Mario Pes
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Side Effects ◽  
Randomized Controlled Trials ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Adult Patients ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Inflammatory Bowel

Probiotics demonstrated to be effective in the treatment of inflammatory bowel disease (IBD). However, the safety profile of probiotics is insufficiently explored. In the present systematic review and meta-analysis, we examined the occurrence of side effects related to probiotic/synbiotic use in randomized controlled trials (RCTs) of IBD patients as compared with placebo. Eligible RCTs in adult patients with IBD were identified by accessing the Medline database via PubMed, EMBASE, CENTRAL and the Cochrane central register of controlled trials up to December 2018. Occurrence of side effects was retrieved and recorded. Data were pooled and the relative risks (RRs) with their 95% confidence intervals (CIs) were calculated. The low-moderate study heterogeneity, assessed by the I2 statistic, allowed to use of a fixed-effects modelling for meta-analysis. Nine RCTs among 2337, including 826 patients (442 treated with probiotics/symbiotic and 384 with placebo) were analyzed. Eight were double-blind RCTs, and six enrolled ulcerative colitis (UC) patients. Although the risk for the overall side effects (RR 1.35, 95%CI 0.93–1.94; I2 = 25%) and for gastrointestinal symptoms (RR 1.78, 95%CI 0.99–3.20; I2 = 20%) was higher in IBD patients taking probiotics than in those exposed to placebo, statistical significance was achieved only for abdominal pain (RR 2.59, 95%CI 1.28–5.22; I2 = 40%). In conclusion, despite the small number of RCTs and the variety of probiotic used and schedule across studies, these findings highlight the level of research effort still required to identify the most appropriate use of probiotics in IBD.

scholarly journals Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease

2016 ◽  
Vol 10 (10) ◽  
pp. 1224-1236 ◽  
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Hai Yun Shi ◽  
Whitney Tang ◽  
Cindy C. Y. Law ◽  
Joseph J. Y. Sung ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Clinical Outcomes ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

Effects of oral Vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yiwen Guo ◽  
Tao Zhang ◽  
Yandan Wang ◽  
Ruijie Liu ◽  
Ming Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Effective Properties ◽  
Meta Analysis ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Oral Vitamin ◽  
Inflammatory Bowel

Vitamin D (VitD) is a fat-soluble micronutrient that plays a critical role in inflammatory bowel disease (IBD). Although the effective properties of VitD in anti-inflammatory and immune moderation were reviewed,...

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