scholarly journals Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet

2019 ◽  
Vol 49 (12) ◽  
pp. 1484-1492 ◽  
Author(s):  
Isabel Comino ◽  
Verónica Segura ◽  
Luis Ortigosa ◽  
Beatríz Espín ◽  
Gemma Castillejo ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Coeliac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Prospective Longitudinal Study ◽  
Immunogenic Peptides ◽  
Prospective Longitudinal

Su1439 Impaired Bone Microstructure Improves After One-Year on Gluten-Free Diet. A Prospective Longitudinal Study in Women With Active Celiac Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-469
Author(s):  
Maria B. Zanchetta ◽  
Ana F. Costa ◽  
Vanesa Longobardi ◽  
Gabriela I. Longarini ◽  
Ma. de la Paz Temprano ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Longitudinal Study ◽  
Bone Microstructure ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Prospective Longitudinal Study ◽  
One Year ◽  
Prospective Longitudinal

Long-Term Improvement of Impaired Bone Microarchitecture in Patients with Celiac Disease on a Gluten-Free Diet. A Prospective Longitudinal Study

2017 ◽  
Vol 152 (5) ◽  
pp. S267
Author(s):  
María Belén Zanchetta ◽  
Ana Costa ◽  
Vanesa Longobardi ◽  
Roberto M. Mazure ◽  
Fernando Silveira ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Longitudinal Study ◽  
Bone Microarchitecture ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Gluten-related immunogenic peptides in stool as means to monitor compliance with gluten-free diet in children with newly dia gnosed coeliac disease

2021 ◽  
Vol 75 (6) ◽  
pp. 519-523
Author(s):  
Radim Vyhnánek ◽  
Ziad Khaznadar ◽  
Roman Vyhnánek ◽  
Milan Paulík
Keyword(s):  
Coeliac Disease ◽  
Blood Sample ◽  
Stool Sample ◽  
Tissue Transglutaminase ◽  
Sandwich Elisa ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Newly Diagnosed ◽  
Strict Adherence ◽  
Immunogenic Peptides

Objectives and study: To compare the values of gluten-related immunogenic peptides (GIP) in stool and anti-tissue transglutaminase IgA antibodies (anti-tTG IgA) in blood in children newly diagnosed with coeliac disease (CD). Methods: All children (2–15 y) newly diagnosed with CD between May 2018 and May 2020 at our clinic who complied with the inclusion criteria were invited to join the prospective study. During workup for CD, a stool sample to measure GIP was taken together with a blood sample to measure anti-tTG IgA. All newly diagnosed children were invited 4 months later for a check-up. Children and their caregivers were asked about known non-compliance with the gluten-free diet (GFD), a blood sample was taken to measure the anti-tTG IgA, and a stool sample was collected to measure GIP. Blood was evaluated for anti-tTG IgA by ELISA, and the stool was tested by quantitative Sandwich ELISA designed to detect and quantify GIP using the G12 antibody. Values of GIP and anti-tTG IgA were compared in terms of their relation to the upper limit of normal (ULN) of the particular method. Results: 29 children (18 girls) were enrolled in the study. The values of GIP in stool at the time of diagnosis were above the ULN (0.15 µg/g) in all children. Average 4.21, median 3.29, standard deviation (SD) 3.7. After the four months, all but three (89.7%) had values of GIP in the reference range. Average 0.29, median 0.12, SD 0.73. Similarly, anti-tTG IgA values were above the ULN (9.9 U/mL) at the time of diagnosis in all children. Average 164, median 195, SD 49. Although the anti-tTG IgA levels were lower at check-up in all but one child, only 10 (34.5%) showed values within the normal range, with an average of 27.9, median 12.0, and SD 38.9. All children declared strict adherence to GFD. Discussion: Using the GIP concentration in stool, adherence to GFD in our cohort of children is very good, better than that described in literature. Conclusion: Measuring GIP in stool could prove a more sensitive indicator of adherence to GFD in the early months after the diagnosis of CD when anti-tTG IgA are still elevated above the ULN due to their well-described gradual decrease after GFD initiation.

scholarly journals Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing

Gut ◽  
2015 ◽  
Vol 66 (2) ◽  
pp. 250-257 ◽  
Author(s):  
María de Lourdes Moreno ◽  
Ángel Cebolla ◽  
Alba Muñoz-Suano ◽  
Carolina Carrillo-Carrion ◽  
Isabel Comino ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Mucosal Healing ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Immunogenic Peptides

Onset of coeliac disease: a prospective longitudinal study

2007 ◽  
Vol 92 (10) ◽  
pp. 1149-1152 ◽  
Author(s):  
K Pittschieler ◽  
L Gentili ◽  
H Niederhofer
Keyword(s):  
Longitudinal Study ◽  
Coeliac Disease ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal
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