scholarly journals The effects of sustained virological response to direct-acting anti-viral therapy on the risk of extrahepatic manifestations of hepatitis C infection

2019 ◽  
Vol 49 (11) ◽  
pp. 1442-1447 ◽  
Author(s):  
Hashem B. El-Serag ◽  
Israel C. Christie ◽  
Amy Puenpatom ◽  
Diana Castillo ◽  
Fasiha Kanwal ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Extrahepatic Manifestations ◽  
Hepatitis C Infection ◽  
Viral Therapy ◽  
Direct Acting ◽  
Anti Viral Therapy

Direct acting anti-viral therapy rescues neutrophil dysfunction in hepatitis C infection by reduction of heamolysis

2018 ◽  
Vol 68 ◽  
pp. S326-S327
Author(s):  
B. Leber ◽  
A. Horvath ◽  
B. Schmerboeck ◽  
A. Posch ◽  
A. Streit ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis C Infection ◽  
Viral Therapy ◽  
Direct Acting ◽  
Neutrophil Dysfunction ◽  
Anti Viral Therapy

Platelet Count Improvement after Chronic Hepatitis C Treatment among Cirrhotic Patients Who Achieved Sustained Virological Response: Realworld Results from 2186 Patients in Egypt

2020 ◽  
Vol 20 ◽  
Author(s):  
Rehab Badawi ◽  
Shaimaa Soliman ◽  
Lobna Aboali ◽  
Mahmoud Elkadeem ◽  
Asem Elfert ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Platelet Count ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Hcv Rna ◽  
End Of Treatment ◽  
Pugh Class ◽  
Direct Acting

Background & Aims: This study aimed to assess the changes in platelet counts of patients with liver cirrhosis due to chronic HCV, who achieved sustained virological response (SVR) after taking direct acting antivirals (DAAs) in a large cohort study in Egypt. Methods: This multicenter observational retrospective study was carried out on 2500 chronic hepatitis C virus (HCV) infected patients who achieved (SVR) after treatment with direct acting antiviral drugs (DAA). HCV infection was confirmed by positive PCR for HCV RNA infection. SVR was defined as a negative PCR test for HCV-RNA 12 weeks after completion of DAA therapy. Platelets count was measured before therapy, during therapy, at the end of treatment, and 12 weeks after the end of the treatment. Results: There were 2186 patients enrolled in the study; 1866 (85.4%) were treatment naïve. There were 1006 (46%) males and 1180 (54%) females. Mean age was 50.82± 11.66 years, 2142 (98 %.0) patients achieved SVR, 2118 (96.9%) patients had Child -Pugh class A cirrhosis, and 68 (3.1%) had Child -Pugh class B liver cirrhosis. A significant increase of the platelets count was detected at the end of treatment in comparison to the pretreatment levels (P<0.001), and after achieving SVR (P <0.001) when compared to the pretreatment values. Conclusion: Improvement of platelets count occurs after HCV therapy with DAAS in patients with liver cirrhosis. These results suggested that HCV eradication may have a role in improvement of platelet count.

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