scholarly journals Letter: nonalcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density

2019 ◽  
Vol 49 (7) ◽  
pp. 960-961 ◽  
Author(s):  
Razieh Bidhendi Yarandi
Keyword(s):  
Bone Mineral Density ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bone Mineral ◽  
Fatty Liver Disease ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Nonalcoholic Fatty Liver ◽  
History Of

Association Between Nonalcoholic Fatty Liver Disease and Bone Mineral Density in HIV-Infected Patients Receiving Long-Term TDF-Based Antiretroviral Therapy

2020 ◽  
Vol 18 ◽  
Author(s):  
Zhijie Xu ◽  
Pengyuan He ◽  
Jianzhong Xian ◽  
Wuzhu Lu ◽  
Jingxian Shu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Liver Disease ◽  
Antiretroviral Therapy ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bone Mineral ◽  
Fatty Liver Disease ◽  
Mineral Density ◽  
Nonalcoholic Fatty Liver

Background: Tenofovir (TDF) has a detrimental effect on bone mineral density (BMD), while nonalcoholic fatty liver disease (NAFLD) is associated with a lower BMD. Objective: To help understand the mutual effects of NAFLD and TDF on BMD, this study was designed to explore the potential association between NAFLD and BMD in HIV-infected patients receiving long-term TDF-based antiretroviral therapy (ART). Method: A total of 89 HIV-infected patients who received TDF-based ART for more than three years were enrolled in this cross-sectional study. We measured BMD using an ultrasonic bone density apparatus, and liver ultrasonography was performed to determine the severity of the fatty liver. The association of NAFLD with BMD was examined using multiple logistic regression analyses. Results: Patients with NAFLD showed a worse BMD status than those without NAFLD. The incidences rates of osteopenia (42.86% versus 25.93%) and osteoporosis (17.14% versus 3.70%) were significantly higher in HIV-infected patients with NAFLD than in those without NAFLD. After multivariate adjustment, the odds ratio (OR) for patients with NAFLD exhibiting a worse BMD status compared with those without NAFLD was 4.49 (95% confidence interval [CI] 1.42, 14.15). Conclusion: Based on our results, NAFLD was significantly associated with a worse BMD status, including osteopenia and osteoporosis, in HIV patients after receiving long-term TDF-based ART. Furthermore, we may want to avoid using TDF for ART in HIV-infected patients with NAFLD.

The evaluation of bone mineral density in patients with nonalcoholic fatty liver disease

2012 ◽  
Vol 124 (15-16) ◽  
pp. 526-531 ◽  
Author(s):  
Tugrul Purnak ◽  
Yavuz Beyazit ◽  
Ersan Ozaslan ◽  
Cumali Efe ◽  
Merve Hayretci
Keyword(s):  
Bone Mineral Density ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bone Mineral ◽  
Fatty Liver Disease ◽  
Mineral Density ◽  
Nonalcoholic Fatty Liver

scholarly journals Association Between Nonalcoholic Fatty Liver Disease and Reduced Bone Mineral Density in Children: A Meta‐Analysis

Hepatology ◽  
2019 ◽  
Vol 70 (3) ◽  
pp. 812-823 ◽  
Author(s):  
Alessandro Mantovani ◽  
Davide Gatti ◽  
Giacomo Zoppini ◽  
Giuseppe Lippi ◽  
Enzo Bonora ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bone Mineral ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Mineral Density ◽  
Nonalcoholic Fatty Liver

scholarly journals Low Bone Mineral Density in Chinese Adults with Nonalcoholic Fatty Liver Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ran Cui ◽  
Hui Sheng ◽  
Xue-Fei Rui ◽  
Xiao-Yun Cheng ◽  
Chun-Jun Sheng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bone Mineral ◽  
Fatty Liver Disease ◽  
Mineral Density ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver ◽  
The Right

Aim. To investigate bone metabolic characteristics in Chinese adults with nonalcoholic fatty liver disease (NAFLD).Methods. A total of 224 patients (99 males and 125 postmenopausal females) were recruited and divided into 4 groups: males without NAFLD, males with NAFLD, females without NAFLD, and females with NAFLD. Bone mineral density (BMD) was evaluated according to body mass index (BMI), waist circumference (WC), and serum biomarkers.βcell function was evaluated by HOMA2%B, HOMA2%S, and HOMA2IR.Results. Males in the NAFLD group had lower BMD of the right hip and the femoral neck (0.852±0.117versus0.930±0.123,P=0.002;0.736±0.119versus0.812±0.132,P=0.004), and females had lower BMD of the right hip (0.725±0.141versus0.805±0.145,P=0.002) even after adjusted for weight, BMI, waist, HDL, and ALT. There was no significant difference in bone metabolic markers between patients with and without NAFLD. NAFLD was an important factor that affected the bone; moreover, the effect attenuated when HOMA2IR entered into the model (R2=0.160,β=−0.172, andP=0.008).Conclusions. NAFLD exerts a detrimental effect on BMD in both males and females. Insulin resistance may play an important role in this pathophysiological process.

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