Microwave vs radiofrequency ablation for hepatocellular carcinoma within the Milan criteria: a propensity score analysis

2018 ◽  
Vol 48 (6) ◽  
pp. 671-681 ◽  
Author(s):  
Wenwu Liu ◽  
Yun Zheng ◽  
Wei He ◽  
Ruhai Zou ◽  
Jiliang Qiu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Milan Criteria ◽  
Score Analysis

Multipolar versus monopolar radiofrequency ablation for hepatocellular carcinoma in the caudate lobe: Results of a propensity score analysis

2016 ◽  
Vol 47 (7) ◽  
pp. 658-667 ◽  
Author(s):  
Masashi Hirooka ◽  
Hironori Ochi ◽  
Atsushi Hiraoka ◽  
Yohei Koizumi ◽  
Yoshio Tokumoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Caudate Lobe ◽  
Score Analysis

scholarly journals Microwave ablation versus resection for hepatocellular carcinoma within the Milan criteria: a propensity-score analysis

2019 ◽  
Vol 11 ◽  
pp. 175883591987465 ◽  
Author(s):  
Wenwu Liu ◽  
Ruhai Zou ◽  
Chenwei Wang ◽  
Jiliang Qiu ◽  
Jingxian Shen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Propensity Score ◽  
Microwave Ablation ◽  
Propensity Score Analysis ◽  
Intrahepatic Recurrence ◽  
Milan Criteria ◽  
Comparable Efficacy ◽  
Score Analysis ◽  
Cox Analysis

Background: Whether the efficient heat-generating mechanism of microwave ablation (MWA) is comparable with resection (RES) in treating hepatocellular carcinoma (HCC) remains unclear. Methods: This retrospective cohort study comprised 126 and 1183 patients with HCC meeting the Milan criteria who received MWA or RES between 2002 and 2017. We compared 5-year overall survival (OS) and recurrence-free survival (RFS) using both propensity-score matching (PSM) and inverse-probability-of-treatment-weighting (IPW) analysis and investigated the prognostic factors with multivariate Cox analysis. Results: After PSM (1:2), although MWA ( n = 116) offered decreased 5-year RFS (30.6% versus 57.5%, p < 0.001) compared with RES ( n = 212), both treatments provided similar 5-year OS (82.2% versus 80.5%, p = 0.360) because most patients with intrahepatic recurrence remained eligible for repeat treatments; similar results were found in the IPW analysis. Additionally, the comparable efficacy of MWA and RES was consistent across all subgroups: those with solitary HCC ⩽ 3.0 cm or >3.0 cm, or multifocal HCCs within the Milan criteria, patients with liver function of albumin–bilirubin grade 1 or 2, and older (⩾60 years) or younger (<60 years) patients. Multivariate Cox analysis confirmed that no difference was seen between MWA and RES in OS (hazard ratio = 0.85; p = 0.581) in the overall population; similar results were obtained in the propensity-score-matched and IPW cohorts. Conclusions: Compared with RES, MWA offered worse RFS for HCC within the Milan criteria; however, both treatments provided equivalent long-term OS because most patients with intrahepatic recurrence remained eligible for repeat treatments.

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