Systematic review with meta-analysis: online psychological interventions for mental and physical health outcomes in gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease

2018 ◽  
Vol 48 (3) ◽  
pp. 244-259 ◽  
Author(s):  
I. Hanlon ◽  
C. Hewitt ◽  
K. Bell ◽  
A. Phillips ◽  
A. Mikocka-Walus
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Gastrointestinal Disorders ◽  
Psychological Interventions ◽  
Physical Health Outcomes ◽  
Inflammatory Bowel ◽  
Irritable Bowel ◽  
Mental And Physical Health

Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children

2015 ◽  
Vol 6 (2) ◽  
pp. 209-217 ◽  
Author(s):  
S. Guandalini ◽  
E. Cernat ◽  
D. Moscoso
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Intestinal Microbiota ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Controlled Trials ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Underlying pathophysiological mechanisms of irritable bowel syndrome (IBS), a common disorder characterized by abdominal pain associated to a change in stool consistency or frequency, include low-grade inflammation and intestinal microbiota changes. Few and disappointing data are available for prebiotics. A few controlled trials (RCTs) of probiotics are instead available with favourable effects, although most are limited by suboptimal design and small sample size. A recent report from the Rome foundation group included 32 RCTs of probiotics, most of which showed an overall modest improvement in symptoms, with the patients most benefitting from probiotics being those with predominant diarrhoea and those having a post-infectious IBS. A review focusing only on children with functional gastrointestinal disorders concluded that probiotics are more effective than placebo in the treatment of patients with abdominal pain-related functional gastrointestinal disorders, although no effect on constipation was evident. The role for probiotics in inflammatory bowel disease (IBD) appears logical: the endogenous intestinal microbiota plays a central role in their development, and various probiotics have been found effective in animal models of IBD. However, research in humans has been overall quite limited, and it would seem that after a phase of intense research in the first decade of this century, the pace has slowed down, with fewer clinical trials been published in the past 2-3 years. To summarize current evidence: no probiotic has proven successful in Crohn's disease. In ulcerative colitis, on the other hand, data are more promising, and a very recent meta-analysis, that included 23 randomized controlled trials, concluded that there is evidence of efficacy for the probiotic mixture VSL#3 in helping inducing and maintaining remission, as well as in maintaining remission in patients with pouchitis. It is fair to state that for both IBD and IBS, more well-designed, rigorous, randomized clinical trials must be performed.

scholarly journals Effectiveness of Fiber Supplementation for Gastrointestinal Function: An Umbrella Review of Meta-Analyses

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1133-1133
Author(s):  
Marc McRae
Keyword(s):  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Significant Heterogeneity ◽  
Umbrella Review ◽  
Funding Sources ◽  
Inflammatory Bowel ◽  
Irritable Bowel ◽  
Meta Analyses

Abstract Objectives To determine if published meta-analyses support the use of fiber supplementation in the treatment of constipation and the dietary support for gastrointestinal disorders such as irritable bowel syndrome, and inflammatory bowel disease. Methods A PubMed search from January 1, 1980 to November 30, 2019 was conducted with the following search strategy: (fiber OR fibre) AND (meta-analysis OR systematic review) AND (constipation OR irritable bowel syndrome OR inflammatory bowel disease). Meta-analyses that provided quantitative statistical analysis with a measured effect size were retrieved and accepted into this review. The following was extracted and entered into an Excel spreadsheet: number of publications included in the meta-analysis, number of total participants, fiber type and daily dose, pooled treatment effects for clinical endpoints and/or summary relative risks (RR's). Results Thirteen meta-analyses support dietary fiber supplementation for patients with constipation and irritable bowel syndrome, but the significant heterogeneity and publication bias undermines the support for using dietary fiber supplementation on these conditions. Conclusions This umbrella review of meta-analyses finds some benefits for recommending fiber supplementation to patients with constipation and irritable bowel syndrome, but significant heterogeneity and publication bias undermines this support. Funding Sources No funding sources were utilized.

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