scholarly journals Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation

2018 ◽  
Vol 47 (11) ◽  
pp. 1428-1439 ◽  
Author(s):  
O. O. Moninuola ◽  
W. Milligan ◽  
P. Lochhead ◽  
H. Khalili
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Meta Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Probiotics as a Coadjuvant Factor in Active or Quiescent Inflammatory Bowel Disease of Adults—A Meta-Analytical Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2628
Author(s):  
Manuel Pabón-Carrasco ◽  
Lucia Ramirez-Baena ◽  
Samuel Vilar-Palomo ◽  
Aurora Castro-Méndez ◽  
Raúl Martos-García ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Relative Risk ◽  
Crohn's Disease ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Unknown Etiology ◽  
Human Beings ◽  
Inflammatory Bowel

(1) Background: Inflammatory bowel diseases are pathologies of unknown etiology and auto-immune pathogenia. The use of probiotics is studied in order to increase the arsenal of treatments. The aim was to assess the efficacy of the probiotics in these diseases in the active or quiescent phases; (2) Methods: A systematic review with meta-analysis was performed by an exhaustive bibliographic search in Medline, Cinahl, Embase, Scopus, Web of Science, and Cochrane Library. The inclusion criteria were studies of more than 10 years, English/Spanish, clinical trials, and involving human beings. Relative risk was used to compare efficacy, which was meta-analyzed using a fixed effects model. Heterogeneity was evaluated with the Higgins I2 test; (3) Results: Nineteen studies were included in the systematic review and 17 in the meta-analysis, with a total of 1537 patients (nexperimental group = 762; nplacebo group = 775). There are significant remission differences in ulcerative colitis (relative risk (RR) = 0.81; 95% CI = 0.72–0.91; I2 = 32%; p = 0.16). However, no significant differences were found in the use of probiotics for the prevention of ulcerative colitis, and for the remission of Crohn’s disease; (4) Conclusions: There are data showing an additional beneficial effect of probiotics on active ulcerative colitis. More and better studies are needed which assess its possible therapeutic efficacy for quiescent ulcerative colitis and for Crohn’s disease.

Sign in / Sign up

Export Citation Format

Share Document