Bariatric surgery is associated with increased risk of new-onset inflammatory bowel disease: case series and national database study

2018 ◽  
Vol 47 (8) ◽  
pp. 1126-1134 ◽  
Author(s):  
R. Ungaro ◽  
R. Fausel ◽  
H. L. Chang ◽  
S. Chang ◽  
L. A. Chen ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Case Series ◽  
National Database ◽  
Database Study ◽  
Increased Risk ◽  
Disease Case ◽  
Inflammatory Bowel ◽  
New Onset

scholarly journals P733 Past history of bariatric surgery associated with increased risk of new onset inflammatory bowel disease

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S455-S456 ◽  
Author(s):  
R. Ungaro ◽  
H. Chang ◽  
L. Roque Ramos ◽  
R. Fausel ◽  
J. Torres ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Past History ◽  
Increased Risk ◽  
History Of ◽  
Inflammatory Bowel ◽  
New Onset

Past History of Bariatric Surgery Associated with Increased Risk of new Onset Inflammatory Bowel Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S972
Author(s):  
Ryan C. Ungaro ◽  
Helena L. Chang ◽  
Lídia M. Roque Ramos ◽  
Rebecca Fausel ◽  
Joana Torres ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Past History ◽  
Increased Risk ◽  
History Of ◽  
Inflammatory Bowel ◽  
New Onset

scholarly journals Bariatric surgery and risk of new-onset inflammatory bowel disease: A nationwide cohort study

2021 ◽  
Author(s):  
Kristine H Allin ◽  
Rikke K Jacobsen ◽  
Ryan C Ungaro ◽  
Jean-Fred Colombel ◽  
Alexander Egeberg ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Incidence Rate ◽  
Bowel Disease ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Increased Risk ◽  
Inflammatory Bowel ◽  
New Onset

Abstract Background & Aims The aim of this study was to examine the risk of new-onset inflammatory bowel disease (IBD) following bariatric surgery. Methods We conducted a nationwide population-based prospective cohort study of the entire Danish population 18 to 60 years of age alive and residing in Denmark from 1996 to 2018. Bariatric surgery was included as a time-dependent variable, and Cox proportional hazards regression models were used to estimate hazard ratios (HRs) of IBD. We used a model adjusting for age, sex, and birth cohort and a multifactor-adjusted model additionally including educational status and number of obesity-related comorbidities. Results We followed 3,917,843 individuals, of which 15,347 had a bariatric surgery, for development of new-onset IBD. During 106,420 person-years following bariatric surgery, 100 IBD events occurred (incidence rate 0.940 / 1000 person years). During 55,553,785 person-years without bariatric surgery, 35,294 events of IBD occurred (incidence rate 0.635 / 1000 person-years). This corresponded to a multifactor-adjusted HR of 1.15 (95% CI, 0.94-1.40) for IBD. Multifactor-adjusted HRs of Crohn’s disease (CD) and ulcerative colitis (UC) were 1.85 (95% CI, 1.40-2.44) and 0.81 (95% CI, 0.61-1.08), respectively. Among women, the multifactor-adjusted HR for CD was 2.18 (95% CI, 1.64-2.90). When limiting the study population to individuals with a diagnosis of overweight/obesity, bariatric surgery remained associated with increased risk of CD, multifactor-adjusted HR 1.59 (95% CI, 1.18-2.13). Conclusions This nationwide cohort study shows that bariatric surgery is associated with increased risk of development of new-onset CD, but not of UC. The underlying mechanisms remain elusive.

Biologic-Induced Infections in Inflammatory Bowel Disease: The TNF-α Antagonists

2018 ◽  
Vol 52 (6) ◽  
pp. 571-579 ◽  
Author(s):  
Sean M. McConachie ◽  
Sheila M. Wilhelm ◽  
Ashish Bhargava ◽  
Pramodini B. Kale-Pradhan
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Opportunistic Infections ◽  
Case Series ◽  
Infectious Risk ◽  
Increased Risk ◽  
Tnf Α ◽  
Inflammatory Bowel ◽  
Meta Analyses

Objective: To review the mechanism and association of infectious risk among the tumor-necrosis factor α (TNF-α) antagonists used in inflammatory bowel disease. Data Sources: A PubMed literature search was performed using the following search terms: infliximab, adalimumab, certolizumab, golimumab, inflammatory bowel disease, crohn’s, ulcerative colitis, adverse effects, adverse events, safety, and infection. Study Selection and Data Extraction: Meta-analyses and cohort studies with outcomes pertaining to quantitative infectious risk were reviewed. Case reports and case series describing association between TNF-α inhibitors and infection were also reviewed. Data Synthesis: A total of 7 recent meta-analyses of randomized trials demonstrate inconclusive association of infection with TNF-α antagonists. Registry data suggest that medications carry an independent risk of opportunistic infections. Risk factors for infection include older age, malnutrition, diabetes, and possibly combination therapy. Reported infections vary widely but include intracellular and granulomatous bacteria, viruses, and fungi. Conclusion: TNF-α antagonists are associated with an increased risk of opportunistic infection, although this risk has not been demonstrated conclusively in randomized controlled trials. Knowledge of concomitant risk factors, mechanism of infectious risk, and available treatment options can improve patient care in the clinical setting.

Inflammatory bowel disease and new-onset psychiatric disorders in pregnancy and post partum: a population-based cohort study

Gut ◽  
2019 ◽  
Vol 68 (9) ◽  
pp. 1597-1605 ◽  
Author(s):  
Simone N Vigod ◽  
Paul Kurdyak ◽  
Hilary K Brown ◽  
Geoffrey C Nguyen ◽  
Laura E Targownik ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mental Illness ◽  
Cohort Study ◽  
Bowel Disease ◽  
Post Partum ◽  
Population Based ◽  
Incidence Rates ◽  
Increased Risk ◽  
Inflammatory Bowel ◽  
New Onset

ObjectivePatients with inflammatory bowel disease (IBD) have an elevated risk of mental illness. We determined the incidence and correlates of new-onset mental illness associated with IBD during pregnancy and post partum.DesignThis cohort study using population-based health administrative data included all women with a singleton live birth in Ontario, Canada (2002–2014). The incidence of new-onset mental illness from conception to 1-year post partum was compared between 3721 women with and 798 908 without IBD, generating adjusted HRs (aHR). Logistic regression was used to identify correlates of new-onset mental illness in the IBD group.ResultsAbout 22.7% of women with IBD had new-onset mental illness versus 20.4% without, corresponding to incidence rates of 150.2 and 132.8 per 1000 patient-years (aHR 1.12, 95% CI 1.05 to 1.20), or one extra case of new-onset mental illness per 43 pregnant women with IBD. The risk was elevated in the post partum (aHR 1.20, 95% CI 1.09 to 1.31), but not during pregnancy, and for Crohn’s disease (aHR 1.12, 95% CI 1.02 to 1.23), but not ulcerative colitis. The risk was specifically elevated for a new-onset mood or anxiety disorder (aHR 1.14, 95% CI 1.04 to 1.26) and alcohol or substance use disorders (aHR 2.73, 95% CI 1.42 to 5.26). Predictors of a mental illness diagnosis were maternal age, delivery year, medical comorbidity, number of prenatal visits, family physician obstetrical care and infant mortality.ConclusionWomen with IBD were at an increased risk of new-onset psychiatric diagnosis in the postpartum period, but not during pregnancy. Providers should look to increase opportunities for prevention, early identification and treatment accordingly.

Autoimmune pancreatitis and inflammatory bowel disease: Case series and review of the literature

2016 ◽  
Vol 48 (8) ◽  
pp. 893-898 ◽  
Author(s):  
Lídia Roque Ramos ◽  
Christopher J. DiMaio ◽  
David B. Sachar ◽  
Ashish Atreja ◽  
Jean-Frédéric Colombel ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Autoimmune Pancreatitis ◽  
Bowel Disease ◽  
Case Series ◽  
Review Of The Literature ◽  
Disease Case ◽  
Inflammatory Bowel
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