scholarly journals Letter: CYP2C19 polymorphisms and exacerbation of rabeprazole's effects on celecoxib-induced small bowel injury

2017 ◽  
Vol 46 (7) ◽  
pp. 706-707 ◽  
Author(s):  
N. R. Srinivas
Keyword(s):  
Small Bowel ◽  
Bowel Injury ◽  
Small Bowel Injury ◽  
Cyp2c19 Polymorphisms

scholarly journals The influence of CYP2C19 polymorphisms on exacerbating effect of rabeprazole in celecoxib-induced small bowel injury

2017 ◽  
Vol 46 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Y. Nuki ◽  
J. Umeno ◽  
E. Washio ◽  
Y. Maehata ◽  
A. Hirano ◽  
...  
Keyword(s):  
Small Bowel ◽  
Bowel Injury ◽  
Small Bowel Injury ◽  
Cyp2c19 Polymorphisms

scholarly journals P2Y12 Inhibitors Exacerbate Low-dose Aspirin-induced Small Bowel Injury in Dual Antiplatelet Therapy

2021 ◽  
Vol 60 (22) ◽  
pp. 3517-3523
Author(s):  
Yukiko Handa ◽  
Shinya Fukushima ◽  
Motoyasu Osawa ◽  
Takahisa Murao ◽  
Osamu Handa ◽  
...  
Keyword(s):  
Small Bowel ◽  
Antiplatelet Therapy ◽  
Low Dose ◽  
Dual Antiplatelet Therapy ◽  
Bowel Injury ◽  
Small Bowel Injury ◽  
P2y12 Inhibitors ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals Clinical study of hollow viscus injury in abdominal trauma

2017 ◽  
Vol 5 (1) ◽  
pp. 39
Author(s):  
Sanjay Jain ◽  
Dinkar Maske ◽  
M. C. Songra
Keyword(s):  
Small Bowel ◽  
Abdominal Trauma ◽  
Road Traffic Accident ◽  
Traffic Accident ◽  
Road Traffic ◽  
Female Gender ◽  
Bowel Injury ◽  
Solid Organ ◽  
Small Bowel Injury ◽  
Hollow Viscus

Background: Abdominal injury is leading cause of morbidity and mortality at present due to great improvement in man's lifestyle and development of industries.Methods: A total 100 cases of abdominal trauma (both blunt and penetrating) were studied in the present study in our institute for period of 18 Months.Results: Males belonging to young age group of 21-30 were most commonly affected. Road traffic accident is most common mode of injury. Abdominal pain seen in 93% of patients. Abdominal tenderness seen in 86% of patients. Plain x ray abdomen erect was sensitive in detecting hollow viscus injuries. Diagnostic peritoneal lavage is better than four quadrant aspirations. Ultrasound examination gives a clear picture of solid organ injury and free fluid. Most common injured viscera in the present study is small bowel and they were managed by simple suturing and closure of perforation and resection and anastomosis. Postoperative complications like wound infection, wound dehiscence, respiratory complications, pelvic abscess and faecal fistula were seen. The duration of stay for most of the patients in this study was between 11-20 days with mean of 15 days. Mortality in this study was 7%. Conditions such as, female gender, long interval between injury and operation, presence of shock on admission, and small bowel injury worsen the prognosis in penetrating abdominal trauma.Conclusions: Young males are most commonly affected due to road traffic accident. Conditions such as, female gender, long interval between injury and operation, presence of shock on admission, and small bowel injury worsen the prognosis in penetrating abdominal trauma.

Role of leukocytes in indomethacin-induced small bowel injury in the rat

1994 ◽  
Vol 266 (2) ◽  
pp. G239-G246 ◽  
Author(s):  
H. M. Chmaisse ◽  
J. S. Antoon ◽  
P. R. Kvietys ◽  
M. B. Grisham ◽  
M. A. Perry
Keyword(s):  
Small Bowel ◽  
Morphological Changes ◽  
Mucosal Injury ◽  
Bowel Injury ◽  
Rat Jejunum ◽  
Small Bowel Injury ◽  
Mucosal Permeability ◽  
Quantitative Histology ◽  
51Cr Edta

This study assesses the role of neutrophils in indomethacin-induced small bowel injury and determines the influence of intestinal pH on the magnitude of this injury. Rat jejunum was perfused via the lumen with buffer, and mucosal injury was assessed by blood-to-lumen clearance of 51Cr-EDTA and quantitative histology. Reduction in luminal pH from 7.4 to 6.0 in the presence of indomethacin (1.0 mg/ml) increased 51Cr-EDTA clearance from 2.0 +/- 0.1 to 6.5 +/- 0.3 microliter.min-1.g-1. Indomethacin caused a reduction in villus length, an increase in villus width, and an increase in lesion score. Depletion of neutrophils with antiserum largely prevented the increase in 51Cr-EDTA clearance and morphological changes. Intravenous indomethacin given at a dose to mimic therapeutic plasma levels (1 mg/kg iv) had no significant effect on 51Cr-EDTA clearance but caused similar morphological changes to those observed following intraluminal administration. The data suggest that neutrophils play a role in acute indomethacin injury and that the drug given intravenously can cause morphological changes without necessarily altering mucosal permeability to 51Cr-EDTA.

Less Small-Bowel Injury With Lumiracoxib Compared With Naproxen Plus Omeprazole

2008 ◽  
Vol 6 (5) ◽  
pp. 536-544 ◽  
Author(s):  
Christopher J. Hawkey ◽  
Christian Ell ◽  
Bernd Simon ◽  
Jörg Albert ◽  
Martin Keuchel ◽  
...  
Keyword(s):  
Small Bowel ◽  
Bowel Injury ◽  
Small Bowel Injury
Sign in / Sign up

Export Citation Format

Share Document