Serial combination of non-invasive tools improves the diagnostic accuracy of severe liver fibrosis in patients with NAFLD

2017 ◽  
Vol 46 (6) ◽  
pp. 617-627 ◽  
Author(s):  
S. Petta ◽  
V. W.-S. Wong ◽  
C. Cammà ◽  
J.-B. Hiriart ◽  
G. L.-H. Wong ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Diagnostic Accuracy ◽  
Severe Liver ◽  
Non Invasive

scholarly journals PTU-001 Diagnostic accuracy of non-invasive liver fibrosis markers in young adults within the ALSPAC population-based cohort

2019 ◽  
Author(s):  
Kushala Abeysekera ◽  
James Orr ◽  
Gwen Fernandes ◽  
Gemma Hammerton ◽  
Andrew Portal ◽  
...  
Keyword(s):  
Young Adults ◽  
Liver Fibrosis ◽  
Diagnostic Accuracy ◽  
Population Based ◽  
Non Invasive

scholarly journals The applicability of non-invasive methods for assessing liver fibrosis in hemodialysis patients with chronic hepatitis C

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242601
Author(s):  
Jia-Jung Lee ◽  
Yu-Ju Wei ◽  
Ming-Yen Lin ◽  
Sheng-Wen Niu ◽  
Po-Yao Hsu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Diagnostic Accuracy ◽  
Chronic Hepatitis C ◽  
Transient Elastography ◽  
Hemodialysis Patients ◽  
Accurate Assessment ◽  
Non Invasive

Background The accurate assessment of liver fibrosis among hemodialysis patients with chronic hepatitis C (CHC) is important for both treatment and for follow up strategies. Applying the non-invasive methods in general population with viral hepatitis have been successful but the applicability of the aminotransferase/platelet ratio index (APRI) or the fibrosis-4 index (FIB-4) in hemodialysis patients need further evaluation. Materials and methods We conducted a prospective, multi-center, uremic cohort to verify the applicability of APRI and FIB-4 in identifying liver fibrosis by reference with the standard transient elastography (TE) measures. Results There were 116 CHC cases with valid TE were enrolled in our analysis. 46 cases (39.6%) were classified as F1, 35 cases (30.2%) as F2, 11 cases (9.5%) as F3, and 24 cases (20.7%) as F4, respectively. The traditional APRI and FIB-4 criteria did not correctly identify liver fibrosis. The optimal cut-off value of APRI was 0.28 and of FIB-4 was 1.91 to best excluding liver cirrhosis with AUC of 76% and 77%, respectively. The subgroup analysis showed that female CHC hemodialysis patients had better diagnostic accuracy with 74.1% by APRI. And CHC hemodialysis patients without hypertension had better diagnostic accuracy with 78.6% by FIB-4. Conclusions This study confirmed the traditional category level of APRI and FIB-4 were unable to identify liver fibrosis of CHC hemodialysis patients. With the adjusted cut-off value, APRI and FIB-4 still showed suboptimal diagnostic accuracy. Our results suggest the necessary of TE measures for liver fibrosis in the CHC uremic population.

New Doppler ultrasound signs improve the non-invasive diagnosis of cirrhosis or severe liver fibrosis

2004 ◽  
Vol 16 (8) ◽  
pp. 743-751 ◽  
Author(s):  
Christophe Aub?? ◽  
Betsy Winkfield ◽  
Fr??d??ric Oberti ◽  
Eric Vuillemin ◽  
Marie C Rousselet ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Doppler Ultrasound ◽  
Severe Liver ◽  
Non Invasive

Assessment of native liver fibrosis using ultrasound elastography and serological fibrosis indices in children with biliary atresia after the Kasai procedure

2020 ◽  
pp. 028418512094848
Author(s):  
Jisun Hwang ◽  
Hee Mang Yoon ◽  
Kyung Mo Kim ◽  
Seak Hee Oh ◽  
Jung-Man Namgoong ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Diagnostic Accuracy ◽  
Biliary Atresia ◽  
Non Invasive ◽  
Kasai Procedure ◽  
Serologic Markers ◽  
Native Liver ◽  
Us Elastography

Background Validated non-invasive examinations are necessary to monitor liver fibrosis in children with biliary atresia (BA) after the Kasai procedure. Purpose To evaluate the diagnostic accuracy of two-dimensional shear wave elastography (2D-SWE), transient elastography (TE), and the serologic biomarkers of aspartate transaminase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) score for evaluating native liver fibrosis in children with BA. Material and Methods We retrospectively reviewed same-day 2D-SWE and TE liver stiffness (LS) measurements of 63 patients with BA who underwent the Kasai procedure. The APRI and FIB-4 score were computed. Hepatic fibrosis was categorized into three clinical categories based on the ultrasound (US) hepatic morphology and clinical manifestations of liver cirrhosis: I, pre-cirrhotic liver state (n = 15); II, US and/or clinical signs of liver cirrhosis with compensated liver function (n = 27); and III, liver cirrhosis with decompensated liver function (n = 21). We compared area under the receiver operating characteristic curve (AUC) data among 2D-SWE, TE, APRI, and FIB-4 score. Combined evaluation of serologic fibrosis indices and US elastography was conducted and AUCs of combinations were analyzed. Results 2D-SWE, TE, APRI, and FIB-4 score showed good to excellent diagnostic accuracy for differentiating clinical categories (AUCs 0.779–0.955). AUC values were significantly increased after adding TE to FIB-4 score for detecting liver cirrhosis ( P = 0.02). Conclusion 2D-SWE, TE, APRI, and FIB-4 score are accurate non-invasive markers for monitoring native liver fibrosis in patients with BA. Combined use of serologic markers and US elastography could yield more accurate diagnoses of liver fibrosis than serologic markers alone.

Systematic review: diagnostic accuracy of non-invasive tests for staging liver fibrosis in autoimmune hepatitis

2018 ◽  
Vol 13 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Shanshan Wu ◽  
Zhirong Yang ◽  
Jialing Zhou ◽  
Na Zeng ◽  
Zhiying He ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Fibrosis ◽  
Diagnostic Accuracy ◽  
Autoimmune Hepatitis ◽  
Non Invasive
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