Mixture model analysis identifies irritable bowel syndrome subgroups characterised by specific profiles of gastrointestinal, extraintestinal somatic and psychological symptoms

2017 ◽  
Vol 46 (5) ◽  
pp. 529-539 ◽  
Author(s):  
A. Polster ◽  
L. Van Oudenhove ◽  
M. Jones ◽  
L. Öhman ◽  
H. Törnblom ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mixture Model ◽  
Psychological Symptoms ◽  
Model Analysis ◽  
Irritable Bowel

scholarly journals Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Laura Prospero ◽  
Giuseppe Riezzo ◽  
Michele Linsalata ◽  
Antonella Orlando ◽  
Benedetta D’Attoma ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Barrier Function ◽  
Rating Scale ◽  
Psychological Symptoms ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Fatty Acid Binding ◽  
Gastrointestinal Symptom Rating Scale ◽  
Gi Symptoms ◽  
Irritable Bowel

Abstract Background Irritable bowel syndrome (IBS) is characterised by gastrointestinal (GI) and psychological symptoms (e.g., depression, anxiety, and somatization). Depression and anxiety, but not somatization, have already been associated with altered intestinal barrier function, increased LPS, and dysbiosis. The study aimed to investigate the possible link between somatization and intestinal barrier in IBS with diarrhoea (IBS-D) patients. Methods Forty-seven IBS-D patients were classified as having low somatization (LS = 19) or high somatization (HS = 28) according to the Symptom Checklist-90-Revised (SCL-90-R), (cut-off score = 63). The IBS Severity Scoring System (IBS-SSS) and the Gastrointestinal Symptom Rating Scale (GSRS) questionnaires were administered to evaluate GI symptoms. The intestinal barrier function was studied by the lactulose/mannitol absorption test, faecal and serum zonulin, serum intestinal fatty-acid binding protein, and diamine oxidase. Inflammation was assessed by assaying serum Interleukins (IL-6, IL-8, IL-10), and tumour necrosis factor-α. Dysbiosis was assessed by the urinary concentrations of indole and skatole and serum lipopolysaccharide (LPS). All data were analysed using a non-parametric test. Results The GI symptoms profiles were significantly more severe, both as a single symptom and as clusters of IBS-SSS and GSRS, in HS than LS patients. This finding was associated with impaired small intestinal permeability and increased faecal zonulin levels. Besides, HS patients showed significantly higher IL-8 and lowered IL-10 concentrations than LS patients. Lastly, circulating LPS levels and the urinary concentrations of indole were higher in HS than LS ones, suggesting a more pronounced imbalance of the small intestine in the former patients. Conclusions IBS is a multifactorial disorder needing complete clinical, psychological, and biochemical evaluations. Trial registration: https://clinicaltrials.gov/ct2/show/NCT03423069.

scholarly journals Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers

2008 ◽  
Vol 14 (31) ◽  
pp. 4889 ◽  
Author(s):  
Elsa M Eriksson ◽  
Kristina I Andrén ◽  
Henry T Eriksson ◽  
Göran K Kurlberg
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychological Symptoms ◽  
Body Awareness ◽  
Stress Markers ◽  
Irritable Bowel

scholarly journals Irritable Bowel Syndrome: A Case Study

2016 ◽  
Vol 31 (4) ◽  
pp. 180-191
Author(s):  
Nadia Sutanto ◽  
Edgar Jeremy
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychological Symptoms ◽  
Gastrointestinal Symptoms ◽  
Psychosocial Stressors ◽  
Depression Anxiety Stress Scale ◽  
Psychological States ◽  
Depth Interview ◽  
The Subject ◽  
Irritable Bowel

Irritable Bowel Syndrome (IBS) is a functional disorder marked by some gastrointestinal symptoms frequently associated with extradigestive symptoms with unknown organic causes. In this study the authors investigated whether IBS causes psychological symptoms or vice versa. Data were collected through an in-depth interview (anamnesis), a hetero-anamnesis, and the Depression Anxiety Stress Scale (DASS-21). The subject was a 20-year-old student (D) diagnosed with IBS since the age of 15. Results showed that the subject had an extremely severe anxiety and stress, and moderate depression. The main obstacle faced by the subject was his escape-avoidance coping strategies which were not appropriately applied in solving problems.This situated the subject in a vicious cycle between recurrent IBS, helplessness, avoidance of responsibility, and anxious/stressful conditions. The subject’s type of personality which tended to be introverted and neurotic made him experience difficulties in overcoming psychosocial stressors, such as academic demands and lack of social relationships. The psychological factors influenced the psychological states of the subject that resulted in the recurrence of IBS.

Tu1810 Distinct Subtypes of Irritable Bowel Syndrome Are Defined by Psychological Symptoms, Visceral Pain Sensitivity, Stool Consistency, and Motility

2016 ◽  
Vol 150 (4) ◽  
pp. S954-S955
Author(s):  
Miranda A. van Tilburg ◽  
Magnus Simren ◽  
Olafur S. Palsson ◽  
Hans Törnblom ◽  
William E. Whitehead
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Sensitivity ◽  
Visceral Pain ◽  
Psychological Symptoms ◽  
Stool Consistency ◽  
Irritable Bowel
Sign in / Sign up

Export Citation Format

Share Document