scholarly journals Editorial: volatile organic compounds in irritable bowel syndrome - technology for an accurate and reliable point-of-care test?

2017 ◽  
Vol 45 (4) ◽  
pp. 563-564 ◽  
Author(s):  
R. Sood ◽  
A. C. Ford
Keyword(s):  
Irritable Bowel Syndrome ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Point Of Care ◽  
Point Of Care Test ◽  
Volatile Organic ◽  
Irritable Bowel

scholarly journals Volatile organic compounds in breath as markers for irritable bowel syndrome: a metabolomic approach

2016 ◽  
Vol 44 (1) ◽  
pp. 45-56 ◽  
Author(s):  
A. Baranska ◽  
Z. Mujagic ◽  
A. Smolinska ◽  
J. W. Dallinga ◽  
D. M. A. E. Jonkers ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Volatile Organic ◽  
Irritable Bowel ◽  
Metabolomic Approach

scholarly journals Volatile Organic Compounds in Feces Associate With Response to Dietary Intervention in Patients With Irritable Bowel Syndrome

2018 ◽  
Vol 16 (3) ◽  
pp. 385-391.e1 ◽  
Author(s):  
Megan Rossi ◽  
Raphael Aggio ◽  
Heidi M. Staudacher ◽  
Miranda C. Lomer ◽  
James O. Lindsay ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Dietary Intervention ◽  
Volatile Organic ◽  
Irritable Bowel

Volatile Organic Compounds in Human Breath: Biogenic Origin and Point-of-Care Analysis Approaches

2013 ◽  
pp. 129-154 ◽  
Author(s):  
Alexander A. Aksenov ◽  
Michael Schivo ◽  
Hamzeh Bardaweel ◽  
Yuriy Zrodnikov ◽  
Alice M. Kwan ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Point Of Care ◽  
Human Breath ◽  
Biogenic Origin ◽  
Volatile Organic

scholarly journals Exhaled volatile organic compounds as markers for medication use in asthma

2019 ◽  
Vol 55 (2) ◽  
pp. 1900544 ◽  
Author(s):  
Paul Brinkman ◽  
Waqar M. Ahmed ◽  
Cristina Gómez ◽  
Hugo H. Knobel ◽  
Hans Weda ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
High Resolution Mass Spectrometry ◽  
Point Of Care ◽  
Characteristic Curve ◽  
Inhalation Technique ◽  
Therapeutic Drug ◽  
Exhaled Breath ◽  
Volatile Organic

IntroductionAsthma is a heterogeneous condition, characterised by chronic inflammation of the airways, typically managed with inhaled bronchodilators and corticosteroids. In the case of uncontrolled asthma, oral corticosteroids (OCSs) are often prescribed. Good adherence and inhalation technique are associated with improved outcomes; however, it is difficult to monitor appropriate drug intake and effectiveness in individual patients. Exhaled breath contains thousands of volatile organic compounds (VOCs) that reflect changes in the body's chemistry and may be useful for monitoring drug pharmacokinetics/pharmacodynamics. We aimed to investigate the association of exhaled VOCs in severe asthma patients from the U-BIOPRED cohort (by gas chromatography coupled with time-of-flight mass spectrometry) with urinary levels of salbutamol and OCSs (by liquid chromatography coupled with high-resolution mass spectrometry).MethodsSamples were collected at baseline and after 12–18 months of follow-up. Statistical analysis was based on univariate and multivariate modelling, followed by area under the receiver operating characteristic curve (AUC) calculation. Results were verified through longitudinal replication and independent validation.ResultsData were available for 78 patients (baseline n=48, replication n=30 and validation n=30). Baseline AUC values were 82.1% (95% CI 70.4–93.9%) for salbutamol and 78.8% (95% CI 65.8–91.8%) for OCS. These outcomes could be adequately replicated and validated. Additional regression analysis between qualified exhaled VOCs and urinary concentrations of salbutamol and prednisone showed statistically significant correlations (p<0.01).ConclusionWe have linked exhaled VOCs to urinary detection of salbutamol and OCSs. This merits further development of breathomics into a point-of-care tool for therapeutic drug monitoring.

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