scholarly journals Randomised clinical trial: the effects of daikenchuto, TU-100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation

2013 ◽  
Vol 37 (8) ◽  
pp. 776-785 ◽  
Author(s):  
J. Iturrino ◽  
M. Camilleri ◽  
B. S. Wong ◽  
S. J. Linker Nord ◽  
D. Burton ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Functional Constipation ◽  
Bowel Function ◽  
Randomised Clinical Trial ◽  
Colonic Transit ◽  
Female Patients

A Randomized Trial of 5-Hydroxytryptamine4–Receptor Agonist, YKP10811, on Colonic Transit and Bowel Function in Functional Constipation

2015 ◽  
Vol 13 (4) ◽  
pp. 701-708.e1 ◽  
Author(s):  
Andrea Shin ◽  
Andres Acosta ◽  
Michael Camilleri ◽  
Amy Boldingh ◽  
Duane Burton ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Receptor Agonist ◽  
Functional Constipation ◽  
Bowel Function ◽  
Colonic Transit

S1302 Dose-Related Effects of Chenodeoxycholate on Gastrointestinal and Colonic Transit and Bowel Function in Female Patients With Constipation-Predominant Irritable Bowel Syndrome

2010 ◽  
Vol 138 (5) ◽  
pp. S-224
Author(s):  
Archana S. Rao ◽  
Suwebatu T. Odunsi ◽  
Michael Camilleri ◽  
Sanna McKinzie ◽  
Duane D. Burton ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Bowel Function ◽  
Colonic Transit ◽  
Female Patients ◽  
Irritable Bowel

scholarly journals Distinctive Pathophysiology Underlying Constipation in Parkinson’s Disease: Implications for Cognitive Inefficiency

2020 ◽  
Vol 9 (6) ◽  
pp. 1916
Author(s):  
Rosalind M. Tucker ◽  
Suzanne Ryan ◽  
Bu’ Hussain Hayee ◽  
Ingvar Bjarnason ◽  
Aisha D. Augustin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Processing ◽  
Transverse Colon ◽  
Functional Constipation ◽  
Bowel Function ◽  
Bowel Dysfunction ◽  
Colonic Transit ◽  
Processing Times ◽  
Low Sensitivity

Depression is associated with constipation within and outside Parkinson’s disease (PD). Since inefficient cognitive-processing (bradyphrenia) features in PD and an enterokinetic agent improved cognitive performance in healthy individuals, bradyphrenia may be associated with constipation. We aim to define the archetypical bowel function of PD, and its association with cognition, mood, and motor features within and outside PD. We assessed colonic transit time (oral radio-opaque markers over 6 days), bowel function and psychometric questionnaires and measures of PD facets, including bradyphrenia, in 58 participants with diagnosed PD, and 71 without (controls). The best abdominal X-ray (day 7) predictors of PD status were total retained marker count and transverse colon segmental delay. However, Rome functional constipation status complemented segmental delay better, giving good specificity (85%) but low sensitivity (56%). Transverse colon marker count appeared to be age-associated only in PD. In PD, those correctly classified by bowel dysfunction had higher depression scores (p = 0.02) and longer cognitive-processing times than the misclassified (p = 0.05). Controls misclassified as PD by bowel dysfunction had higher depression and anxiety scores than the correctly classified (p = 0.002 and 0.003, respectively), but not slower cognitive processing. Measures of motor features were independent of sub-classification by bowel function in PD and in controls. In conclusion, constipation in PD has distinct localized pathophysiology, and is associated with bradyphrenia.

scholarly journals Open: Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial

2018 ◽  
Vol 113 (5) ◽  
pp. 725-734 ◽  
Author(s):  
Ibironke Oduyebo ◽  
Michael Camilleri ◽  
Alfred D. Nelson ◽  
Disha Khemani ◽  
Sara Linker Nord ◽  
...  
Keyword(s):  
Functional Constipation ◽  
Bowel Function ◽  
Colonic Transit ◽  
Phase 2 ◽  
Phase 2 Trial ◽  
Randomized Phase 2
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