Performance on the Wisconsin card-sorting test and serum levels of glial cell line-derived neurotrophic factor in patients with major depressive disorder

2014 ◽  
Vol 6 (3) ◽  
pp. 302-307 ◽  
Author(s):  
Xiaobin Zhang ◽  
Bu Ru ◽  
Weiwei Sha ◽  
Wang Xin ◽  
Honghui Zhou ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cell Line ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Major Depressive ◽  
Wisconsin Card Sorting ◽  
Sorting Test

The relationship between cognitive function and clinical and functional outcomes in major depressive disorder

2008 ◽  
Vol 39 (3) ◽  
pp. 393-402 ◽  
Author(s):  
A. Withall ◽  
L. M. Harris ◽  
S. R. Cumming
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Major Depressive ◽  
Perseverative Errors ◽  
Wisconsin Card Sorting ◽  
Sorting Test

BackgroundAlthough cognitive variables have been shown to be useful in predicting outcomes in late-life depression, there has not yet been a comprehensive study in younger persons with depression.MethodThe clinical symptoms and cognitive performance of participants were evaluated at admission to one of two university teaching hospitals and again at 3 months after remission and discharge. A total of 52 participants with a DSM-IV diagnosis of major depressive disorder, aged between 20 and 60 years and with a Hamilton Depression Rating Scale score ⩾17 entered the study. The sample for this paper comprises the 48 subjects (mean age 37.9 years, s.d.=10.7) who received admission and follow-up assessments; an attrition rate of 7.7%.ResultsMore perseverative errors on the shortened Wisconsin Card Sorting Test at admission predicted a worse clinical outcome at follow-up. Poor event-based prospective memory and more perseverative errors on the shortened Wisconsin Card Sorting Test at admission predicted worse social and occupational outcome at follow-up.ConclusionsThese results suggest that a brief cognitive screen at hospital admission, focusing on executive function, would have a useful prognostic value in depression. Determining early predictors of individuals at risk of poorer outcomes is important for identifying those who may need altered or additional treatment approaches.

scholarly journals Evaluation of cognitive impairment in patients with major depressive disorder in remission

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Mustafa Ali ◽  
Magda Fahmy ◽  
Wafaa Haggag ◽  
Ashraf El-Tantawy ◽  
Haydy Hassan
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cognitive Functions ◽  
Visual Memory ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Control Groups ◽  
Major Depressive ◽  
Sorting Test ◽  
And Control

Abstract Background Cognitive symptoms are one of the core symptoms of depressive disorders with a bearing effect on functional outcomes. Cognitive symptoms, including poor concentration and difficulty making decisions, are one of the DSM-IV diagnostic criteria for major depressive disorder. This study was designed to evaluate cognitive deficits in a sample of adult patients with major depressive disorder (MDD) in remission. A cross-sectional study was done on 60 patients fulfilling the diagnostic criteria of MDD in remission state. In addition, 60 normal subjects with matched age, sex, and educational level were compared with the patients group. Participants in both patients and control groups were subjected to clinical assessment using Mini-International Neuropsychiatric Interview plus (MINI-plus), assessment of cognitive functions using Wechsler Memory Scale-Revised (WMS-R) short form, and Wisconsin Card Sorting Test (WCST). Results There were statistically significant differences between patients and control groups regarding cognitive function. The patients group scored less in visual memory, verbal memory, attention/concentration, and psychomotor speed. They also performed poorly regarding executive functions. But there was no statistically significant difference between the patients and control groups regarding sustained attention and visuospatial function. No significant correlations did exist between age at onset of MDD and the duration of illness with different domains of cognitive function except for figural memory of WMS-R and categories completed of Wisconsin card sorting test. Conclusion Patients with MDD in remission experienced deficits in several cognitive functions when compared to matched control subjects. The cognitive functions do not reach normal levels of performance, particularly in visual memory and executive functioning with remission of depressive symptoms.

scholarly journals Evaluation of Serum Glial Cell Line-derived Neurotrophic Factor in Bangladeshi Major Depressive Disorder Patients

Cureus ◽  
2019 ◽  
Author(s):  
Rajesh Das ◽  
Md Prova Zaman Emon ◽  
Sayeeda Fahmee Chowdhury ◽  
Sumaiya Huque ◽  
Tanzan Zahan ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Major Depressive

Plasma glial cell line-derived neurotrophic factor in patients with major depressive disorder: a preliminary study

2015 ◽  
Vol 28 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Bun-Hee Lee ◽  
Jin-Pyo Hong ◽  
Jung-A Hwang ◽  
Kyoung-Sae Na ◽  
Won-Joong Kim ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Recurrent Episode ◽  
First Episode ◽  
Healthy Controls ◽  
Major Depressive ◽  
Before And After

BackgroundSome clinical studies have reported reduced peripheral glial cell line-derived neurotrophic factor (GDNF) level in elderly patients with major depressive disorder (MDD). We verified whether a reduction in plasma GDNF level was associated with MDD.MethodPlasma GDNF level was measured in 23 healthy control subjects and 23 MDD patients before and after 6 weeks of treatment.ResultsPlasma GDNF level in MDD patients at baseline did not differ from that in healthy controls. Plasma GDNF in MDD patients did not differ significantly from baseline to the end of treatment. GDNF level was significantly lower in recurrent-episode MDD patients than in first-episode patients before and after treatment.ConclusionsOur findings revealed significantly lower plasma GDNF level in recurrent-episode MDD patients, although plasma GDNF levels in MDD patients and healthy controls did not differ significantly. The discrepancy between our study and previous studies might arise from differences in the recurrence of depression or the ages of the MDD patients.

scholarly journals Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

2009 ◽  
Vol 31 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Juliana Fernandes Tramontina ◽  
Denise Yates ◽  
Pedro Vieira da Silva Magalhães ◽  
Clarissa Trentini ◽  
Márcia Kauer Sant'Anna ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Val66met Polymorphism ◽  
Factor Gene ◽  
Wisconsin Card Sorting ◽  
Sorting Test ◽  
The Brain

OBJECTIVE: In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder. METHOD: Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor. RESULTS: The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains. CONCLUSION: Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.

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