Reliability of Ki67 visual scoring app compared to eyeball estimate and digital image analysis and its prognostic significance in hormone receptor positive breast cancer

Apmis ◽  
2021 ◽  
Author(s):  
Indu Arun ◽  
Saranya Venkatesh ◽  
Rosina Ahmed ◽  
Sanjit Kumar Agrawal ◽  
Samuel C.Y. Leung
Keyword(s):  
Breast Cancer ◽  
Image Analysis ◽  
Digital Image ◽  
Hormone Receptor ◽  
Digital Image Analysis ◽  
Prognostic Significance ◽  
Hormone Receptor Positive ◽  
Visual Scoring ◽  
Positive Breast Cancer

scholarly journals ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE

2020 ◽  
Vol 19 (4) ◽  
pp. 138-145
Author(s):  
D. B. Erdyneeva ◽  
N. N. Babyshkina ◽  
T. A. Dronova ◽  
S. V. Vtorushin ◽  
E. M. Slonimskaya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cyclin D1 ◽  
Hormone Receptor ◽  
Molecular Subtype ◽  
Regulatory Protein ◽  
Prognostic Significance ◽  
Tamoxifen Resistance ◽  
Hormone Receptor Positive ◽  
Tamoxifen Efficacy ◽  
Positive Breast Cancer

Hormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a selective estrogen receptor modulator, remains the first adjuvant treatment choice for the hormone-receptor positive BC patients. However, tamoxifen resistance is the major limitation of its efficacy. In this regard, the study of drug resistance mechanisms as well as search for biological prognostic markers of tamoxifen efficacy is very important. Cyclin D1 is a representative of the regulatory protein family, which plays a central role in the cell cycle regulation. The data on the association between cyclin D1 and estrogen-dependent signaling as well as the characteristics of CCND1 gene and its most studied polymorphic loci, were presented. The prognostic significance of cyclin D1 in hormone-receptor positive BC receptor-positive breast cancer was described. The experimental and clinical studies data on the association between the cyclin D1 expression level and tamoxifen efficacy are analyzed. Current approaches to overcoming hormone resistance based on cyclin D1 studies were considered.

Imunohistocheminių biožymenų tyrimai hormonų receptorių teigiamos duktalinės krūties karcinomos mikroaplinkos erdviniame kontekste skaitmeninės vaizdo analizės metodu

2021 ◽  
Author(s):  
◽  
Dovilė Žilėnaitė
Keyword(s):  
Image Analysis ◽  
Breast Carcinoma ◽  
Digital Image ◽  
Hormone Receptor ◽  
Digital Image Analysis ◽  
Spatial Context ◽  
Ductal Breast Carcinoma ◽  
Hormone Receptor Positive

Assessing immunohistochemistry biomarkers in the spatial context of the microenvironment of hormone receptor-positive ductal breast carcinoma by digital image analysis

Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer

2019 ◽  
Vol 476 (5) ◽  
pp. 701-709 ◽  
Author(s):  
Norie Abe ◽  
Hirofumi Matsumoto ◽  
Reika Takamatsu ◽  
Kentaro Tamaki ◽  
Naoko Takigami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Image Analysis ◽  
Digital Image ◽  
Digital Image Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Infiltrating Lymphocytes ◽  
Positive Breast Cancer
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