scholarly journals Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019

Apmis ◽  
2021 ◽  
Vol 129 (5) ◽  
pp. 271-279
Author(s):  
Mehdi Shahbazi ◽  
Mohammad Jafari ◽  
Zahra Moulana ◽  
Mahdi Sepidarkish ◽  
Mojgan Bagherzadeh ◽  
...  
2011 ◽  
Vol 141 (3) ◽  
pp. 1014-1023 ◽  
Author(s):  
Tomohisa Sujino ◽  
Takanori Kanai ◽  
Yuichi Ono ◽  
Yohei Mikami ◽  
Atsushi Hayashi ◽  
...  

2000 ◽  
Vol 15 (11) ◽  
pp. 1312-1317 ◽  
Author(s):  
Katsutoshi Tokushige ◽  
Katsumi Yamauchi ◽  
Tatsuji Komatsu ◽  
Ken Takasaki ◽  
Naoaki Hayashi

2012 ◽  
Vol 206 (2) ◽  
pp. 158-166 ◽  
Author(s):  
Gabriel K. Pedersen ◽  
Abdullah S. Madhun ◽  
Lucy Breakwell ◽  
Katja Hoschler ◽  
Haakon Sjursen ◽  
...  
Keyword(s):  
T Helper ◽  

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Rishi Vishal Luckheeram ◽  
Rui Zhou ◽  
Asha Devi Verma ◽  
Bing Xia

CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell, follicular helper T cell, and T-helper 9, each with a characteristic cytokine profile. For a particular phenotype to be differentiated, a set of cytokine signaling pathways coupled with activation of lineage-specific transcription factors and epigenetic modifications at appropriate genes are required. The effector functions of these cells are mediated by the cytokines secreted by the differentiated cells. This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells.


2007 ◽  
Vol 104 (37) ◽  
pp. 14765-14770 ◽  
Author(s):  
N. Hayashi ◽  
T. Yoshimoto ◽  
K. Izuhara ◽  
K. Matsui ◽  
T. Tanaka ◽  
...  

2017 ◽  
Vol 130 (15) ◽  
pp. 1810-1815 ◽  
Author(s):  
Ming-Hui Li ◽  
Dan Zhang ◽  
Lu Zhang ◽  
Xiao-Jing Qu ◽  
Yao Lu ◽  
...  

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