Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology toHelicobacter pyloriHspB inH. pylori-infected patients

Apmis ◽  
2019 ◽  
Vol 127 (3) ◽  
pp. 139-149 ◽  
Author(s):  
Weronika Gonciarz ◽  
Agnieszka Matusiak ◽  
Karolina Rudnicka ◽  
Tomasz Rechciński ◽  
Maciej Chałubiński ◽  
...  
Keyword(s):  
Peptide Epitope ◽  
Specific Peptide ◽  
Human Hsp60

scholarly journals Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

2021 ◽  
Author(s):  
Lucie Loyal ◽  
Julian Braun ◽  
Larissa Henze ◽  
Beate Kruse ◽  
Manuela Dingeldey ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Cd4 T Cells ◽  
Cross Reactivity ◽  
High Rate ◽  
Human Coronavirus ◽  
Peptide Epitope ◽  
Cross Immunity ◽  
Fusion Domain ◽  
Specific Peptide

While evidence for pre-existing SARS-CoV-2-cross-reactive CD4+ T cells in unexposed individuals is increasing, their functional significance remains unclear. Here, we comprehensively determined SARS-CoV-2-cross-reactivity and human coronavirus-reactivity in unexposed individuals. SARS-CoV-2-cross-reactive CD4+ T cells were ubiquitous, but their presence decreased with age. Within the spike glycoprotein fusion domain, we identified a universal immunodominant coronavirus-specific peptide epitope (iCope). Pre-existing spike- and iCope-reactive memory T cells were efficiently recruited into mild SARS-CoV-2 infections and their abundance correlated with higher IgG titers. Importantly, the cells were also reactivated after primary BNT162b2 COVID-19 mRNA vaccination in which their kinetics resembled that of secondary immune responses. Our results highlight the functional importance of pre-existing spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Abundant spike-specific cross-immunity may be responsible for the unexpectedly high efficacy of current vaccines even with single doses and the high rate of asymptomatic/mild infection courses.

scholarly journals Enhanced suppression of polyclonal CD8 + 25 + regulatory T cells via exosomal arming of antigen-specific peptide/MHC complexes

2017 ◽  
Vol 101 (5) ◽  
pp. 1221-1231 ◽  
Author(s):  
Chuanyong Mu ◽  
Xueshu Zhang ◽  
Lu Wang ◽  
Aizhang Xu ◽  
Khawaja Ashfaque Ahmed ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Specific Peptide

scholarly journals Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates

2010 ◽  
Vol 49 (49) ◽  
pp. 9530-9533 ◽  
Author(s):  
Michael Bachmann ◽  
Karsten Goede ◽  
Annette G. Beck-Sickinger ◽  
Marius Grundmann ◽  
Anders Irbäck ◽  
...  
Keyword(s):  
Microscopic Mechanism ◽  
Semiconductor Substrates ◽  
Specific Peptide

scholarly journals A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 ◽  
Vol 187 (9) ◽  
pp. 1427-1438 ◽  
Author(s):  
Hidehiro Kishimoto ◽  
Charles D. Surh ◽  
Jonathan Sprent
Keyword(s):  
Negative Selection ◽  
Cell Receptor ◽  
Staphylococcal Enterotoxin B ◽  
Thymic Medulla ◽  
Enterotoxin B ◽  
High Doses ◽  
Specific Peptide ◽  
Selection Of

To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1–100 μg of staphylococcal enterotoxin B (SEB) induced clonal elimination of SEB-reactive Vβ8+ cells at the level of the semi-mature population of HSAhi CD4+ 8− cells found in the thymic medulla; deletion of CD4+ 8+ cells was minimal. SEB injection also caused marked elimination of Vβ8+ HSAhi CD4+ 8− thymocytes in lpr/lpr mice. Paradoxically, however, elimination of these cells in lpr/lpr mice was induced by low-to-moderate doses of SEB (≤1 μg) but not by high doses (100 μg). Similar findings applied when T cell receptor transgenic mice were injected with specific peptide. These findings suggest that clonal elimination of semi-mature medullary T cells is Fas independent at low doses of antigen but Fas dependent at high doses. Previous reports documenting that negative selection is not obviously impaired in lpr/lpr mice could thus reflect that the antigens studied were expressed at only a low level.

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