The impact of langerin (CD207)+ dendritic cells and FOXP3+ Treg cells in the small bowel mucosa of children with celiac disease and atopic dermatitis in comparison to children with functional gastrointestinal disorders

Apmis ◽  
2016 ◽  
Vol 124 (8) ◽  
pp. 689-696 ◽  
Author(s):  
Tamara Vorobjova ◽  
Krista Ress ◽  
Katrin Luts ◽  
Oivi Uibo ◽  
Raivo Uibo
Keyword(s):  
Dendritic Cells ◽  
Atopic Dermatitis ◽  
Celiac Disease ◽  
Small Bowel ◽  
Functional Gastrointestinal Disorders ◽  
Treg Cells ◽  
Gastrointestinal Disorders ◽  
Small Bowel Mucosa ◽  
The Impact ◽  
Bowel Mucosa

scholarly journals The impact of morphological changes in small bowel mucosa on iron metabolism in children with celiac disease

2016 ◽  
Vol 11 (2) ◽  
Author(s):  
Leonid Klimov ◽  
Marina Stoyan ◽  
Victoria Kuryaninova ◽  
Vyacheslav Kashnikov ◽  
Valentina Botasheva ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Iron Metabolism ◽  
Morphological Changes ◽  
Small Bowel Mucosa ◽  
The Impact ◽  
Bowel Mucosa

scholarly journals Celiac Disease in Children, Particularly with Accompanying Type 1 Diabetes, Is Characterized by Substantial Changes in the Blood Cytokine Balance, Which May Reflect Inflammatory Processes in the Small Intestinal Mucosa

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Tamara Vorobjova ◽  
Aili Tagoma ◽  
Astrid Oras ◽  
Kristi Alnek ◽  
Kalle Kisand ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Small Bowel ◽  
Inflammatory Response ◽  
Lamina Propria ◽  
Small Bowel Mucosa ◽  
Anti Inflammatory ◽  
Bowel Mucosa

Cytokines play a pivotal role in the maintenance of intestinal homeostasis inducing pro- or anti-inflammatory response and mucosal barrier function in celiac disease (CD) and type 1 diabetes (T1D). We aimed to compare the levels of pro- and anti-inflammatory cytokines in CD patients without and with coexisting T1D, as well as to evaluate its association with the presence of enteroviruses (EV), regulatory T cells (Tregs), and dendritic cells (DCs) in small bowel mucosa. Altogether, 72 patients (median age 10.1 years) who had undergone small bowel biopsy were studied. The study group consisted of 24 patients with CD (median age 6.5 years), 9 patients with CD and concomitant T1D (median age 7.0 years), two patients with T1D (median age 8.5 years), and 37 patients (median age 14.0 years) with functional gastrointestinal disorders (FGD) and a normal small bowel mucosa as controls. The levels of 33 cytokines in serum were measured by multiple analysis using the Milliplex® MAP Magnetic Bead assay. The densities of FOXP3+ Tregs, CD11c+ DC, indoleamine 2,3-dioxygenase+ (IDO+) DC, langerin+ (CD207+) DCs, and EV were evaluated by immunohistochemistry as described in our previous studies. Circulating anti-EV IgA and IgG were evaluated using ELISA. The most important finding of the study is the significant increase of the serum levels of IL-5, IL-8, IL-13, IL-15, IL-17F, IL-22, IL-27, IP-10, MIP-1β, sIL-2Rα, sTNFRII, and TNFαin CD patients compared to controls and its correlation with the degree of small bowel mucosa damage graded according to the Marsh classification. The leptin level was higher in females in all study groups. The levels of IL-2, IL-6, IL-12 (P70), IL-15, IP-10, and IFNγcorrelated significantly with the density of FOXP3+ Tregs inlamina propriaof the small bowel mucosa, which supports the evidence about the signaling role of these cytokines in the peripheral maintenance of FOXP3+ Tregs. At the same time, a significant negative correlation occurred between the level of IL-4 and density of FOXP3+ Tregs in controls. Another important finding of our study was the correlation of IL-17F, IP-10, sTNFRII, MCP-1, and GM-CSF with the density of EV-positive cells in thelamina propriaof the small bowel mucosa. Correlation of MIP-1 (CCL-4) with CD103+ DC and langerin+ DC densities may point to their significance in the recruitment of immune cells into thelamina propriaand in driving the inflammatory response in CD patients. Our results suggest the predominance of Th1 and Th17 immune responses over EV VP1 protein in CD and T1D patients. The significant elevation of Th2 cytokines, like IL-5 and IL-13, but not IL-4, in CD patients and its correlation with the degree of small bowel mucosa damage could reflect the role of these cytokines in gut defense and inflammation.

scholarly journals Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73658 ◽  
Author(s):  
Yessica L. Allegretti ◽  
Constanza Bondar ◽  
Luciana Guzman ◽  
Eduardo Cueto Rua ◽  
Nestor Chopita ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Cellular Stress ◽  
Small Bowel Mucosa ◽  
Bowel Mucosa

scholarly journals Celiac disease in children - modern diagnostic approach

2008 ◽  
Vol 136 (Suppl. 2) ◽  
pp. 152-157
Author(s):  
Nedeljko Radlovic
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Diagnostic Value ◽  
Iga Deficiency ◽  
Elimination Diet ◽  
Gluten Free Diet ◽  
Permanent Teeth ◽  
Gluten Free ◽  
Small Bowel Mucosa ◽  
Bowel Mucosa

Celiac disease presents a hereditary disorder of gluten tolerance, i.e. of gliadin and related prolamins of wheat, rye and barley. It primarily occurs in Caucasians (1:100-300), while it is considerably or exceptionally rare in colored races. It is particularly frequent in close relatives of the patient, as well as in persons with congenital IgA deficiency and in patients with autoimmune and some chromosomal diseases. The basis of the disease, as well as the key finding in its diagnostics, lies in small bowel inflammation, which withdraws on gluten free diet. Beside clinically manifest or non-manifest enteropathy, changes involving other organs and systems are also frequently seen. The diagnosis of the manifest form of the disease is based on characteristic pathohistological finding detected by the examination of small bowel mucosa in patients on standard diets and their clinical improvement after the introduction of gluten free diet. However, in the diagnosis of the asymptomatic form of the disease, it is necessary to perform enterobiopsy, which confirms the normalization of the appearance of small bowel mucosa in patients on the elimination diet. In children with gluten sensitive enteropathy detected in the first two years of life, as well as in cases in which mucosa samples taken on the first enterobiopsy do not have typical appearance or are inadequate for a reliable interpretation, a definite diagnosis is made based on biopsy finding during the provocation of gluten tolerance. As the quality of permanent teeth can be disturbed, this procedure is not suggested to be done before the completed age of 6 years, and due to adverse effects on the growth and development of the child, it should not be done during puberty. Due to incomplete sensitivity and specificity, the serological indicators of the disease do not have diagnostic value. Therefore, they are primarily used in the disclosure of asymptomatic and atypical forms of celiac disease, as well as in the assessment of the consistency of elimination diet in cases with already verified disease. In addition, the application of these tests makes easier passing the decision to perform pathohistological examination of small bowel mucosa in patients with provoked gluten tolerance, which also gives a more complete understanding into the remission of the disease during the initial phase of treatment.

Celiac Disease Is Not Related to the Loss of T-cell CD5 in the Small Bowel Mucosa

2012 ◽  
Vol 107 ◽  
pp. S130
Author(s):  
Iram Khan ◽  
Noor Khozam ◽  
Dipti Surve ◽  
Metin Ozdemirli ◽  
Aline Charabaty
Keyword(s):  
Celiac Disease ◽  
T Cell ◽  
Small Bowel ◽  
Small Bowel Mucosa ◽  
Bowel Mucosa
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