Ablation of MicroRNAs in VIP + Interneurons Impairs Olfactory Discrimination and Decreases Neural Activity in the Olfactory Bulb

2022 ◽  
Author(s):  
Jing Wu ◽  
Penglai Liu ◽  
Xingfeng Mao ◽  
Fang Qiu ◽  
Ling Gong ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Neural Activity ◽  
Olfactory Discrimination

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

2019 ◽  
Vol 227 (2) ◽  
Author(s):  
Changcheng Sun ◽  
Keke Tang ◽  
Jing Wu ◽  
Han Xu ◽  
Wenfeng Zhang ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Neural Activity ◽  
Olfactory Discrimination

scholarly journals Plasticity of Sniffing Pattern and Neural Activity in the Olfactory Bulb of Behaving Mice During Odor Sampling, Anticipation, and Reward

2020 ◽  
Vol 36 (6) ◽  
pp. 598-610
Author(s):  
Penglai Liu ◽  
Tiantian Cao ◽  
Jinshan Xu ◽  
Xingfeng Mao ◽  
Dejuan Wang ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Neural Activity

scholarly journals Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination

2013 ◽  
Vol 110 (36) ◽  
pp. 14777-14782 ◽  
Author(s):  
Alexia Nunez-Parra ◽  
Robert K. Maurer ◽  
Krista Krahe ◽  
Richard S. Smith ◽  
Ricardo C. Araneda
Keyword(s):  
Olfactory Bulb ◽  
Granule Cells ◽  
Olfactory Discrimination

Cholinergic modulation in the olfactory bulb influences spontaneous olfactory discrimination in adult rats

2006 ◽  
Vol 24 (11) ◽  
pp. 3234-3244 ◽  
Author(s):  
Nathalie Mandairon ◽  
Casara Jean Ferretti ◽  
Conor M. Stack ◽  
Daniel B. Rubin ◽  
Thomas A. Cleland ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Olfactory Discrimination ◽  
Cholinergic Modulation ◽  
Adult Rats

scholarly journals Olfactory Discrimination Learning Increases the Survival of Adult-Born Neurons in the Olfactory Bulb

2006 ◽  
Vol 26 (41) ◽  
pp. 10508-10513 ◽  
Author(s):  
M. Alonso ◽  
C. Viollet ◽  
M.-M. Gabellec ◽  
V. Meas-Yedid ◽  
J.-C. Olivo-Marin ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Discrimination Learning ◽  
Olfactory Discrimination ◽  
Adult Born Neurons

Neurogenic correlates of an olfactory discrimination task in the adult olfactory bulb

2006 ◽  
Vol 24 (12) ◽  
pp. 3578-3588 ◽  
Author(s):  
Nathalie Mandairon ◽  
Joëlle Sacquet ◽  
Samuel Garcia ◽  
Nadine Ravel ◽  
François Jourdan ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Discrimination Task ◽  
Olfactory Discrimination

scholarly journals Effects of intranasal instillation of nanoparticulate matter in the olfactory bulb

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
So Young Kim ◽  
Kyung Woon Kim ◽  
So Min Lee ◽  
Sohyeon Park ◽  
Byeong-Gon Kim ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Temporal Cortex ◽  
Olfactory Discrimination ◽  
Control Group ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Discrimination Ability ◽  
Y Maze ◽  
Cation Transporters ◽  
Intranasal Instillation

AbstractNanoparticulate matter activates the aryl hydrocarbon receptor (AhR) pathway in the respiratory system in a process involving the AhR nuclear translocator (ARNT) and cytochrome P450 family 1, member A1 (CYP1A1). We examined changes in AhR-related pathways following intranasal instillation of nanoparticulate matter in the olfactory bulb and cerebral cortex. Twice a day for 5 days per week for 1 week or 2 weeks, 8-week-old Sprague–Dawley rats were intranasally instilled with 10 µL nanoparticulate matter (nano group; n = 36). An equal volume of saline was intranasally instilled in control rats (n = 36). One week after intranasal instillation, olfactory function and Y-maze tests were performed. The expression levels of AhR in the olfactory bulb and temporal cortex were analyzed using western blotting and immunofluorescence assays. The expression levels of AhR, CYP1A1, inducible nitric oxide synthase (iNOS), and five genes encoding cation transporters (ARNT, ATP7B, ATPB1, OCT1, and OCT2) in the olfactory bulb were analyzed using quantitative reverse transcription. The olfactory discrimination capability was reduced in the nano group compared with the control group. Proportional changes in the Y-maze test were not significantly different between the nano and control groups. AhR mRNA and protein expression in the olfactory bulb increased 1.71-fold (P < 0.001) and 1.60-fold (P = 0.008), respectively. However, no significant changes were observed in the temporal cortex. In the olfactory bulb, the expression of ARNT, ATP7B, ATPB1, and OCT2 was downregulated. CYP1A1 and iNOS expression in the olfactory bulb was upregulated compared with that in the temporal cortex. The intranasal instillation of nanoparticulate matter decreased the olfactory discrimination ability, which was accompanied by upregulation of AhR expression and downregulation of cation transporters in the olfactory bulb.

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