Attenuation of inward rectifier potassium current contributes to the α1‐adrenergic receptor‐induced proarrhythmicity in the caval vein myocardium

2020 ◽  
Author(s):  
Alexandra D. Ivanova ◽  
Tatiana S. Filatova ◽  
Denis V. Abramochkin ◽  
Andrew Atkinson ◽  
Halina Dobrzynski ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Potassium Current ◽  
Inward Rectifier ◽  
Caval Vein ◽  
Inward Rectifier Potassium Current

scholarly journals Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart

2015 ◽  
Vol 467 (12) ◽  
pp. 2437-2446 ◽  
Author(s):  
Minna Hassinen ◽  
Jaakko Haverinen ◽  
Matt E. Hardy ◽  
Holly A. Shiels ◽  
Matti Vornanen
Keyword(s):  
Danio Rerio ◽  
Potassium Current ◽  
Inward Rectifier ◽  
Inward Rectifier Potassium Current

Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine

2017 ◽  
Vol 390 (5) ◽  
pp. 471-481 ◽  
Author(s):  
Markéta Bébarová ◽  
Peter Matejovič ◽  
Olga Švecová ◽  
Roman Kula ◽  
Milena Šimurdová ◽  
...  
Keyword(s):  
Potassium Current ◽  
Inward Rectifier ◽  
Inward Rectifier Potassium Current

A DPDPE-induced enhancement of inward rectifier potassium current via opioid receptor in neuroblastoma×glioma NG108-15 cells

2000 ◽  
Vol 36 (3) ◽  
pp. 209-214 ◽  
Author(s):  
YuLiang Shi ◽  
FenSheng Huang ◽  
WenYan Chen ◽  
Ying Wu ◽  
Yun Tang ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Potassium Current ◽  
Inward Rectifier ◽  
Inward Rectifier Potassium Current

Ionic Mechanisms Mediating the Differential Effects of Methohexital and Thiopental on Action Potential Duration in Guinea Pig and Rabbit Isolated Ventricular Myocytes 

1999 ◽  
Vol 90 (1) ◽  
pp. 156-164 ◽  
Author(s):  
Anatoly E. Martynyuk ◽  
Timothy E. Morey ◽  
Pekka M.J. Raatikainen ◽  
Christoph N. Seubert ◽  
Donn M. Dennis
Keyword(s):  
Guinea Pig ◽  
Potassium Current ◽  
Ventricular Myocytes ◽  
Inward Rectifier ◽  
Delayed Rectifier ◽  
Delayed Rectifier Potassium Current ◽  
Ionic Mechanisms ◽  
Inward Rectifier Potassium Current ◽  
Calcium Inward Current ◽  
Outward Potassium Current

Background Commonly used barbiturate anesthetics may significantly influence cardiac electrophysiologic characteristics. The authors evaluated thiopental (a thiobarbiturate) and methohexital (an oxybarbiturate), two compounds with similar physicochemical properties but different structures, to determine whether they have distinct effects on the major ionic currents that determine action potential duration (APD) in ventricular myocytes. Methods The effects of thiopental and methohexital (50 microM) on APD at 50% (APD50) and 90% (APD90) repolarization were studied in guinea pig and rabbit single ventricular myocytes using the patch-clamp technique in a whole-cell configuration. The ionic mechanisms underlying the APD changes were evaluated by measuring the anesthetics' effects on the L-type calcium inward current, the inward rectifier potassium current, and the delayed rectifier potassium current in guinea pig cells and on the transient outward potassium current in rabbit cells. Results Thiopental and methohexital caused opposite effects on APD. Whereas thiopental prolonged APD50 and APD90 in guinea pig and rabbit ventricular myocytes, methohexital shortened them. Thiopental markedly depressed both the inward and outward components of the inward rectifier potassium current, whereas methohexital caused minimal inhibition of the inward component and no change in the outward component. The delayed rectifier potassium current was inhibited by thiopental but significantly potentiated by methohexital. Neither thiopental nor methohexital significantly affected the transient outward potassium current or the L-type calcium inward current. Conclusions Despite their similar lipid solubilities, molecular weights, and pKa values, thiopental increased and methohexital decreased the APD in ventricular myocytes by predominantly inhibiting the inward rectifier potassium current and the delayed rectifier potassium current and by increasing the delayed rectifier potassium current, respectively. These characteristics suggest distinct structure-specific actions of barbiturates on the function of myocardial ionic channels.

G protein specificity of the muscarine-induced increase in an inward rectifier potassium current in AtT-20 cells

1996 ◽  
Vol 26 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Tohru Kozasa ◽  
Yoshito Kaziro ◽  
Tomokazu Ohtsuka ◽  
John J. Grigg ◽  
Shigehiro Nakajima ◽  
...  
Keyword(s):  
G Protein ◽  
Potassium Current ◽  
Inward Rectifier ◽  
Protein Specificity ◽  
Inward Rectifier Potassium Current

scholarly journals G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

2013 ◽  
Vol 101 (1) ◽  
pp. 175-184 ◽  
Author(s):  
Bo Liang ◽  
Jakob D. Nissen ◽  
Morten Laursen ◽  
Xiaodong Wang ◽  
Lasse Skibsbye ◽  
...  
Keyword(s):  
G Protein ◽  
Potassium Current ◽  
Inward Rectifier ◽  
Ventricular Repolarization ◽  
Inward Rectifier Potassium Current ◽  
G Protein Coupled
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