scholarly journals Deregulated hypoxic response in myeloid cells: A model for high‐altitude pulmonary oedema (HAPE)

2020 ◽  
Vol 229 (2) ◽  
Author(s):  
Milos Gojkovic ◽  
Gabriella S. Darmasaputra ◽  
Pedro Veliça ◽  
Helene Rundqvist ◽  
Randall S. Johnson
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema ◽  
Myeloid Cells ◽  
Hypoxic Response

The genetic basis of high-altitude pulmonary oedema

2004 ◽  
Vol 101 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Heather Mortimer ◽  
Sam Patel ◽  
Andrew J. Peacock
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema ◽  
Genetic Basis

Treatment of high-altitude pulmonary oedema

The Lancet ◽  
1992 ◽  
Vol 340 (8833) ◽  
pp. 1468 ◽  
Author(s):  
A JAMIESON
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema

scholarly journals Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension

2020 ◽  
Vol 58 (1) ◽  
pp. 815-827
Author(s):  
Tingting Wang ◽  
Jun Hou ◽  
Wenjing Xiao ◽  
Yaolei Zhang ◽  
Longfu Zhou ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Medicinal Plants ◽  
High Altitude ◽  
Pulmonary Oedema ◽  
Chinese Medicinal Plants

scholarly journals Acute high-altitude sickness

2017 ◽  
Vol 26 (143) ◽  
pp. 160096 ◽  
Author(s):  
Andrew M. Luks ◽  
Erik R. Swenson ◽  
Peter Bärtsch
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema ◽  
Cerebral Oedema ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Acute Mountain Sickness ◽  
Resonance Imaging ◽  
Altitude Sickness ◽  
Pulmonary Vasoconstriction ◽  
Prevention And Treatment ◽  
Mountain Sickness

At any point 1–5 days following ascent to altitudes ≥2500 m, individuals are at risk of developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome of nonspecific symptoms including headache, lassitude, dizziness and nausea; high-altitude cerebral oedema, a potentially fatal illness characterised by ataxia, decreased consciousness and characteristic changes on magnetic resonance imaging; and high-altitude pulmonary oedema, a noncardiogenic form of pulmonary oedema resulting from excessive hypoxic pulmonary vasoconstriction which can be fatal if not recognised and treated promptly. This review provides detailed information about each of these important clinical entities. After reviewing the clinical features, epidemiology and current understanding of the pathophysiology of each disorder, we describe the current pharmacological and nonpharmacological approaches to the prevention and treatment of these diseases.

High Altitude Pulmonary Oedema

2011 ◽  
Vol 157 (1) ◽  
pp. 68-72 ◽  
Author(s):  
D. Hall ◽  
K. Duncan ◽  
J. K. Baillie
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema

CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema

2011 ◽  
Vol 122 (6) ◽  
pp. 299-311 ◽  
Author(s):  
Aastha Mishra ◽  
Zahara Ali ◽  
Arpana Vibhuti ◽  
Rahul Kumar ◽  
Perwez Alam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Altitude ◽  
Pulmonary Oedema ◽  
Hypobaric Hypoxia ◽  
Glutathione Transferase ◽  
Prostaglandin F2α ◽  
Gene Interactions ◽  
Potential Candidate ◽  
Genotype Distribution ◽  
Risk Alleles

HAPE (high-altitude pulmonary oedema) is characterized by pulmonary hypertension, vasoconstriction and an imbalance in oxygen-sensing redox switches. Excess ROS (reactive oxygen species) contribute to endothelial damage under hypobaric hypoxia, hence the oxidative-stress-related genes CYBA (cytochrome b−245 α polypeptide) and GSTP1 (glutathione transferase Pi 1) are potential candidate genes for HAPE. In the present study, we investigated the polymorphisms −930A/G and H72Y (C/T) of CYBA and I105V (A/G) and A114V (C/T) of GSTP1, individually and in combination, in 150 HAPE-p (HAPE patients), 180 HAPE-r (HAPE-resistant lowland natives) and 180 HLs (healthy highland natives). 8-Iso-PGF2α (8-iso-prostaglandin F2α) levels were determined in plasma and were correlated with individual alleles, genotype, haplotype and gene–gene interactions. The relative expression of CYBA and GSTP1 were determined in peripheral blood leucocytes. The genotype distribution of −930A/G, H72Y (C/T) and I105V (A/G) differed significantly in HAPE-p compared with HAPE-r and HLs (P≤0.01). The haplotypes G-C of −930A/G and H72Y (C/T) in CYBA and G-C and G-T of I105V (A/G) and A114V (C/T) in GSTP1 were over-represented in HAPE-p; in contrast, haplotypes A-T of −930A/G and H72Y (C/T) in CYBA and A-C of I105V (A/G) and A114V (C/T) in GSTP1 were over-represented in HAPE-r and HLs. 8-Iso-PGF2α levels were significantly higher in HAPE-p and in HLs than in HAPE-r (P=2.2×10−16 and 1.2×10−14 respectively) and the expression of CYBA and GSTP1 varied differentially (P<0.05). Regression analysis showed that the risk alleles G, C, G and T of −930A/G, H72Y (C/T), I105V (A/G) and A114V (C/T) were associated with increased 8-iso-PGF2α levels (P<0.05). Interaction between the two genes revealed over-representation of most of the risk-allele-associated genotype combinations in HAPE-p and protective-allele-associated genotype combinations in HLs. In conclusion, the risk alleles of CYBA and GSTP1, their haplotypes and gene–gene interactions are associated with imbalanced oxidative stress and, thereby, with high-altitude adaptation and mal-adaptation.

scholarly journals Doppler assessment of hypoxic pulmonary vasoconstriction and susceptibility to high altitude pulmonary oedema.

Thorax ◽  
1995 ◽  
Vol 50 (1) ◽  
pp. 22-27 ◽  
Author(s):  
J L Vachiery ◽  
T McDonagh ◽  
J J Moraine ◽  
J Berre ◽  
R Naeije ◽  
...  
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Pulmonary Vasoconstriction

scholarly journals Ventilatory and pulmonary vascular response to hypoxia and susceptibility to high altitude pulmonary oedema

1995 ◽  
Vol 8 (11) ◽  
pp. 1825-1833 ◽  
Author(s):  
E. Hohenhaus ◽  
A. Paul ◽  
R.E. McCullough ◽  
H. Kücherer ◽  
P. Bärtsch
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema ◽  
Vascular Response

scholarly journals Augmentation of frusemide diuresis by morphine in high altitude pulmonary oedema.

Heart ◽  
1967 ◽  
Vol 29 (5) ◽  
pp. 709-713 ◽  
Author(s):  
I Singh ◽  
M Lal ◽  
P K Khanna ◽  
N T Mathew
Keyword(s):  
High Altitude ◽  
Pulmonary Oedema
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