scholarly journals Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk‐related rat model of heart failure with preserved ejection fraction

2019 ◽  
Vol 228 (3) ◽  
Author(s):  
Daniela Miranda‐Silva ◽  
Rob C. I. Wüst ◽  
Glória Conceição ◽  
Patrícia Gonçalves‐Rodrigues ◽  
Nádia Gonçalves ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Rat Model ◽  
Cytosolic Calcium ◽  
Calcium Handling ◽  
Metabolic Risk ◽  
Preserved Ejection Fraction

scholarly journals Telmisartan ameliorates cardiac fibrosis and diastolic function in cardiorenal heart failure with preserved ejection fraction

2021 ◽  
pp. 153537022110350
Author(s):  
Di Chang ◽  
Ting-Ting Xu ◽  
Shi-Jun Zhang ◽  
Yu Cai ◽  
Shu-Dan Min ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Factor ◽  
Ejection Fraction ◽  
Diastolic Function ◽  
Rat Model ◽  
Cardiac Fibrosis ◽  
Left Ventricular ◽  
Male Rats ◽  
Preserved Ejection Fraction ◽  
Collagen Iii

Chronic kidney disease (CKD) is a major contributor to the development of heart failure with preserved ejection fraction (HFpEF), whereas the underlying mechanism of cardiorenal HFpEF is still elusive. The aim of this study was to investigate the role of cardiac fibrosis in a rat model of cardiorenal HFpEF and explore whether treatment with Telmisartan, an inhibitor of renin-angiotensin-aldosterone system (RAAS), can ameliorate cardiac fibrosis and preserve diastolic function in cardiorenal HFpEF. Male rats were subjected to 5/6 subtotal nephrectomy (SNX) or sham operation (Sham), and rats were allowed four weeks to recover and form a stable condition of CKD. Telmisartan or vehicle was then administered p.o. (8 mg/kg/d) for 12 weeks. Blood pressure, brain natriuretic peptide (BNP), echocardiography, and cardiac magnetic resonance imaging were acquired to evaluate cardiac structural and functional alterations. Histopathological staining, real-time polymerase chain reaction (PCR) and western blot were performed to evaluate cardiac remodeling. SNX rats showed an HFpEF phenotype with increased BNP, decreased early to late diastolic transmitral flow velocity (E/A) ratio, increased left ventricular (LV) hypertrophy and preserved ejection fraction (EF). Pathology revealed increased cardiac fibrosis in cardiorenal HFpEF rats compared with the Sham group, while chronic treatment with Telmisartan significantly decreased cardiac fibrosis, accompanied by reduced markers of fibrosis (collagen I and collagen III) and profibrotic cytokines (α-smooth muscle actin, transforming growth factor-β1, and connective tissue growth factor). In addition, myocardial inflammation was decreased after Telmisartan treatment, which was in a linear correlation with cardiac fibrosis. Telmisartan also reversed LV hypertrophy and E/A ratio, indicating that Telmisartan can improve LV remodeling and diastolic function in cardiorenal HFpEF. In conclusion, cardiac fibrosis is central to the pathology of cardiorenal HFpEF, and RAAS modulation with Telmisartan is capable of alleviating cardiac fibrosis and preserving diastolic dysfunction in this rat model.

Rat Model of Heart Failure With Preserved Ejection Fraction: Changes in Contractile Proteins Regulating Ca 2+ Cycling and Vascular Reactivity

Circulation ◽  
2021 ◽  
Vol 144 (16) ◽  
pp. 1355-1358
Author(s):  
Young Soo Han ◽  
Grace M. Arteaga ◽  
Korosh Sharain ◽  
Gary C. Sieck ◽  
Frank V. Brozovich
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Rat Model ◽  
Vascular Reactivity ◽  
Contractile Proteins ◽  
Preserved Ejection Fraction

Abstract P490: Vascular Rarefaction And Decreased Angiogenic Potential In The Development Of Left Ventricular Diastolic Dysfunction In Heart Failure With Preserved Ejection Fraction

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Katie Anne Fopiano ◽  
Yanna Tian ◽  
Vadym Buncha ◽  
Liwei Lang ◽  
Zsolt Bagi
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Diastolic Dysfunction ◽  
Rat Model ◽  
Ex Vivo ◽  
Diastolic Heart Failure ◽  
Left Ventricular ◽  
Coronary Microvascular Dysfunction ◽  
Preserved Ejection Fraction ◽  
Angiogenic Potential

Coronary microvascular dysfunction (CMD) develops in patients with heart failure with preserved ejection fraction (HFpEF, also known as diastolic heart failure), but the nature of the underlying pathomechanisms behind this prevalent disease remain poorly understood. The hypothesis tested was that coronary microvascular rarefaction contributes to left ventricle (LV) diastolic function in HFpEF. The obese ZSF1 rat model of human HFpEF was employed and using transthoracic echocardiography it was found that 18-week-old male obese ZSF1 rats exhibited a significantly reduced E/A ratio (E=early, A=late mitral inflow peak velocities) and increased DT (E wave deceleration time) with no change in ejection fraction, indicating diastolic dysfunction. Coronary arteriolar and capillary trees were labeled using Tomato Lectin (Lycopersicon esculentum) DyLight®594 and were imaged by fluorescent confocal microscopy to generate image stacks for 3D reconstruction. Unbiased automated tracing of the microvasculature was done using VesselLucida360 software (MBF) followed by a morphometric analysis (VesselLucida Explorer). It was found that total vessel length and the number of vessel’s branching nodes were reduced in the obese ZSF1 rats, whereas the total vessel’s volumes remained consistent, when compared to the lean ZSF1 controls. These changes in the microvasculature were accompanied by decreased angiogenesis in the coronary arteries in the obese ZSF1 rats when compared to the lean ZSF1 rats using an ex vivo endothelial sprouting assay. From these results, it was concluded that vascular rarefaction and decreased angiogenesis both play a role in the development of LV diastolic dysfunction in the obese ZSF1 rat model of human HFpEF.

scholarly journals Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction

2017 ◽  
Vol 174 (22) ◽  
pp. 4070-4086 ◽  
Author(s):  
Grazia Esposito ◽  
Donato Cappetta ◽  
Rosa Russo ◽  
Alessia Rivellino ◽  
Loreta Pia Ciuffreda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Diastolic Function ◽  
Rat Model ◽  
Preserved Ejection Fraction

scholarly journals Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction

2019 ◽  
Vol 12 (7) ◽  
Author(s):  
Sara Leite ◽  
Rui J. Cerqueira ◽  
Jaime Ibarrola ◽  
Dulce Fontoura ◽  
Amaya Fernández-Celis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Rat Model ◽  
Arterial Remodeling ◽  
Preserved Ejection Fraction

scholarly journals 0257 : Cardiac function under stress conditions in heart failure with preserved ejection fraction rat model

2016 ◽  
Vol 8 (3) ◽  
pp. 235
Author(s):  
Valentine Prat ◽  
David Roul ◽  
Marine Ferron ◽  
Angélique Erraud ◽  
Nicolas Piriou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiac Function ◽  
Rat Model ◽  
Stress Conditions ◽  
Preserved Ejection Fraction

scholarly journals Retracted “Effect of Shensong Yangxin on heart failure in preserved ejection fraction rat model”

2021 ◽  
Vol 19 (12) ◽  
pp. 2697
Author(s):  
Weiwei Zhang ◽  
Qian Sun ◽  
Hao Chen ◽  
Qiang Zhang
Keyword(s):  
Heart Failure ◽  
Experimental Design ◽  
Ejection Fraction ◽  
Rat Model ◽  
Publication Ethics ◽  
Preserved Ejection Fraction

This article previously published in Volume 17 Issue 12 of this journal in December 2018 has been retracted in line with the guidelines  from the Committee on Publication Ethics (COPE, http://publicationethics.org/resources/guidelines). Retraction: Zhang W, Sun Q, Chen H, Zhang Q. Effect of Shensong Yangxin on heart failure in preserved ejection fraction rat model. Trop J Pharm Res 2018;  17(12):2427-2432 doi: http://dx.doi.org/10.4314/tjpr.v17i12.17 To the editor:Many readers have written to me with questions about my article. We have found out that there was anomission in the experimental design hence some of the results could not be repeated. Therefore, wedecided that the paper should be retracted to avoid misleading the readers. Sincerely, Qian Sun. Keywords: Heart failure, Ejection fraction, Shensong Yangxin

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