scholarly journals [Ca 2+ ] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries—Relation to noradrenaline release and contraction

2019 ◽  
Vol 226 (4) ◽  
Author(s):  
Thomas Hansen ◽  
Olga S. Tarasova ◽  
Makhala M. Khammy ◽  
Avelino Ferreira ◽  
James A. Kennard ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Noradrenaline Release ◽  
Mesenteric Arteries

Freeze-Etch Studies on the Innervation of Mesenteric Arteries and Vas Deferens

1971 ◽  
Vol 9 (2) ◽  
pp. 411-425
Author(s):  
C. E. DEVINE ◽  
F. O. SIMPSON ◽  
W. S. BERTAUD
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Schwann Cells ◽  
Synaptic Vesicles ◽  
Vas Deferens ◽  
Muscle Cells ◽  
Mesenteric Arteries ◽  
Axonal Membrane ◽  
Freeze Etching

The innervation of mesenteric arteries and vas deferens of guinea-pig and vas deferens of mouse was examined by freeze-etching. Axons in bundles at large distances from the smooth muscle cells, were invested by Schwann cells and contained mainly neurotubules, while axons close to the smooth muscle cells had varicosities up to 1.6 µm in diameter and 2.0 µm long containing mainly small (approximately 50 nm) and large (approximately 100 nm) synaptic vesicles. Vascular axons differed from those in the vas deferens in that the former were at the medial adventitial border with an observed closest neuromuscular distance of approximately 200 nm and the latter were between smooth muscle cells at distances of 20-50 nm. Depressions of the axonal surface were seen and particles up to 15 nm were found on the axonal membrane.

scholarly journals Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries

2001 ◽  
Vol 85 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Kazumasa Shinozuka ◽  
Yoshie Tanioka ◽  
Young Mi Kwon ◽  
Naoko Tanaka ◽  
Yoko Kubota ◽  
...  
Keyword(s):  
Noradrenaline Release ◽  
Mesenteric Arteries

Ultrastructure of Giant Mitochondria and Their Inclusions in Schwann Cells of Bovine Splenic Nerve

1974 ◽  
Vol 32 ◽  
pp. 194-195
Author(s):  
Å. Thureson-Klein
Keyword(s):  
Schwann Cells ◽  
Cell Organelles ◽  
Giant Mitochondria ◽  
Matrix Density ◽  
Physiological Conditions ◽  
Unmyelinated Axons ◽  
Internal Structures ◽  
Structural Abnormalities ◽  
Cytotoxic Compounds ◽  
Cell Components

Giant mitochondria of various shapes and with different internal structures and matrix density have been observed in a great number of tissues including nerves. In most instances, the presence of giant mitochondria has been associated with a known disease or with abnormal physiological conditions such as anoxia or exposure to cytotoxic compounds. In these cases degenerative changes occurred in other cell organelles and, therefore the giant mitochondria also were believed to be induced structural abnormalities.Schwann cells ensheating unmyelinated axons of bovine splenic nerve regularly contain giant mitochondria in addition to the conventional smaller type (Fig. 1). These nerves come from healthy inspected animals presumed not to have been exposed to noxious agents. As there are no drastic changes in the small mitochondria and because other cell components also appear reasonably well preserved, it is believed that the giant mitochondria are normally present jin vivo and have not formed as a post-mortem artifact.

Human Neurofibromas in Co-Culture with Mouse Neurons

1982 ◽  
Vol 40 ◽  
pp. 194-195
Author(s):  
R.L. Martuza ◽  
T. Liszczak ◽  
A. Okun ◽  
T-Y Wang
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Genetic Disorder ◽  
Cranial Nerves ◽  
Sympathetic Nerves ◽  
Acoustic Neuromas ◽  
Spinal Roots ◽  
Neural Crest Origin ◽  
Multiple Abnormalities ◽  
Other Neoplasms

Neurofibromatosis (NF) is an autosomal dominant genetic disorder with a prevalence of 1/3,000 births. The NF mutation causes multiple abnormalities of various cells of neural crest origin. Schwann cell tumors (neurofibromas, acoustic neuromas) are the most common feature of neurofibromatosis although meningiomas, gliomas, and other neoplasms may be seen. The schwann cell tumors commonly develop from the schwann cells associated with sensory or sympathetic nerves or their ganglia. Schwann cell tumors on ventral spinal roots or motor cranial nerves are much less common. Since the sensory neuron membrane is known to contain a mitogenic factor for schwann cells, we have postulated that neurofibromatosis may be due to an abnormal interaction between the nerve and the schwann cell and that this interaction may be hormonally modulated. To test this possibility a system has been developed in which an enriched schwannoma cell culture can be obtained and co-cultured with pure neurons.

Correlation Between Noradrenaline Fluxes, Metabolism and Compartmentalisation in Human Platelets

1982 ◽  
Vol 48 (01) ◽  
pp. 062-066 ◽  
Author(s):  
Chantal Legrand ◽  
Véronique Dubernard ◽  
Philippe Meyer
Keyword(s):  
Noradrenaline Release ◽  
Human Platelets ◽  
Release Of Noradrenaline ◽  
Storage Pool ◽  
Platelet Storage ◽  
Efflux Of Noradrenaline ◽  
Preferential Localization

Summary(3H) noradrenaline was taken up by human platelets and partially converted into sulfoconjugated noradrenaline. This uptake was inhibited by drugs which have been previously shown to impair the uptake of 5-HT (ouabain, chlorimipramine) or the storage of 5-HT (tyramine, reserpine) by platelets. In addition, tyramine and reserpine stimulated the formation of sulfoconjugated noradrenaline. The efflux of noradrenaline from platelets was measured in parallel and was found to be directly related to the proportion of non metabolized to metabolized noradrenaline in the cells. Unlike tyramine, which induced a similar release of noradrenaline and 5-HT, reserpine was less effective at inducing noradrenaline release than 5-HT release. This study indicates a preferential localization of noradrenaline in the granular pool of human platelets with the existence of an extragranular sulfoconjugated pool which is increased when the granular storage of noradrenaline is impaired. Studies of noradrenaline fluxes and metabolism may be useful in the understanding of both acquired and inherited platelet storage pool defects.

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