scholarly journals Autophagy is induced by resistance exercise in young men, but unfolded protein response is induced regardless of age

2018 ◽  
Vol 224 (1) ◽  
pp. e13069 ◽  
Author(s):  
J. Hentilä ◽  
J. P. Ahtiainen ◽  
G. Paulsen ◽  
T. Raastad ◽  
K. Häkkinen ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Unfolded Protein Response ◽  
Young Men ◽  
Unfolded Protein ◽  
Protein Response

The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout

2014 ◽  
Vol 307 (6) ◽  
pp. R664-R669 ◽  
Author(s):  
Daniel I. Ogborn ◽  
Bryon R. McKay ◽  
Justin D. Crane ◽  
Gianni Parise ◽  
Mark A. Tarnopolsky
Keyword(s):  
Protein Synthesis ◽  
Protein Kinase ◽  
Resistance Exercise ◽  
Unfolded Protein Response ◽  
Initiation Factor ◽  
Knee Extensors ◽  
Leg Extension ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

Endoplasmic reticulum (ER) stress results from an imbalance between the abundance of synthesized proteins and the folding capacity of the ER. In response, the unfolded protein response (UPR) attempts to restore ER function by attenuating protein synthesis and inducing chaperone expression. Resistance exercise (RE) stimulates protein synthesis; however, a postexercise accumulation of unfolded proteins may activate the UPR. Aging may impair protein folding, and the accumulation of oxidized and misfolded proteins may stimulate the UPR at rest in aged muscle. Eighteen younger ( n = 9; 21 ± 3 yr) and older ( n = 9; 70 ± 4 yr) untrained men completed a single, unilateral bout of RE using the knee extensors (four sets of 10 repetitions at 75% of one repetition maximum on the leg press and leg extension) to determine whether the UPR is increased in resting, aged muscle and whether RE stimulates the UPR. Muscle biopsies were taken from the nonexercised and exercised vastus lateralis at 3, 24, and 48 h postexercise. Age did not affect any of the proteins and transcripts related to the UPR. Glucose-regulated protein 78 (GRP78) and protein kinase R-like ER protein kinase (PERK) proteins were increased at 48 h postexercise, whereas inositol-requiring enzyme 1 alpha (IRE1α) was elevated at 24 h and 48 h. Despite elevated protein, GRP78 and PERK mRNA was unchanged; however, IRE1α mRNA was increased at 24 h postexercise. Activating transcription factor 6 (ATF6) mRNA increased at 24 h and 48 h, whereas ATF4, CCAAT/enhancer-binding protein homologous protein (CHOP), and growth arrest and DNA damage protein 34 mRNA were unchanged. These data suggest that RE activates specific pathways of the UPR (ATF6/IRE1α), whereas PERK/eukaryotic initiation factor 2 alpha/CHOP does not. In conclusion, acute RE results in UPR activation, irrespective of age.

Unfolded protein response pathway, IRE1[alpha]-XBP1 is altered during adipogenesis in obese human adipocytes

2013 ◽  
pp. 1-1
Author(s):  
Philip Voyias ◽  
Ciara McCarthy ◽  
Adaikala Antonysunil ◽  
Warunee Kumsaiyai ◽  
Alison Harte ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Human Adipocytes ◽  
Unfolded Protein ◽  
Obese Human ◽  
Protein Response

Oestrogen-driven changes in the bovine uterus are associated with activation of the unfolded protein response

2014 ◽  
Author(s):  
Mohammed A Alfattah ◽  
Paul Anthony McGettigan ◽  
John Arthur Browne ◽  
Khalid M Alkhodair ◽  
Katarzyna Pluta ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response
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