scholarly journals Mode of perfusion influences infarct size, coronary flow and stress kinases in the isolated mouse heart

2016 ◽  
Vol 220 (1) ◽  
pp. 36-46 ◽  
Author(s):  
M. Bliksøen ◽  
A. Rutkovskiy ◽  
J. Vaage ◽  
K.-O. Stensløkken
Keyword(s):  
Infarct Size ◽  
Coronary Flow ◽  
Mouse Heart ◽  
Stress Kinases

scholarly journals Correlation between RDW, Infarct Size and Coronary Flow after Primary Angioplasty

2015 ◽  
Vol 28 (5) ◽  
Author(s):  
Bruna Morais Barbosa ◽  
Maria Emilia Lueneberg ◽  
Roberto Leo da Silva ◽  
Tammuz Fattah ◽  
Gustavo Henrique Bregagnollo ◽  
...  
Keyword(s):  
Infarct Size ◽  
Coronary Flow ◽  
Primary Angioplasty

scholarly journals Balloon Deflation Strategy during Primary Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Clinical Trial and Numerical Simulation-Based Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Jun Gu ◽  
Yang Zhuo ◽  
Tian-jiao Liu ◽  
Jie Li ◽  
Zhao-fang Yin ◽  
...  
Keyword(s):  
Infarct Size ◽  
Coronary Flow ◽  
Coronary Intervention ◽  
Primary Pci ◽  
Hemodynamic Changes ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Percutaneous Coronary

Background. Primary percutaneous coronary intervention (PCI) is the best available reperfusion strategy in patients with acute ST-segment elevation myocardial infarction (STEMI). However, PCI is associated with a serious problem known as no-reflow phenomenon, resulting in poor clinical and functional outcomes. This study aimed to compare the influences of different balloon deflation velocity on coronary flow and cardiovascular events during primary PCI in STEM as well as transient hemodynamic changes in in vitro experiments. Method and Results. 211 STEMI patients were randomly assigned to either a rapid or a slow balloon deflation group during stent deployment. The primary end point was coronary flow at the end of PCI procedure, and secondary end points included myocardial infarct size. Transient hemodynamic changes were evaluated through an in vitro experimental apparatus and a computer model. In clinical practice, the level of corrected TIMI frame count (cTFC) in slow balloon deflation after primary PCI was significantly lower than that of rapid balloon deflation, which was associated with smaller infarct size. Numerical simulations revealed that the rapid deflation led to a sharp acceleration of flow in the balloon-vessel gap and a concomitant abnormal rise in wall shear stress (WSS). Conclusion. This randomized study demonstrated that the slow balloon deflation during stent implantation improved coronary flow and reduced infarct size in reperfused STEMI. The change of flow in the balloon-vessel gap and WSS resulted from different balloon deflation velocity might be partly accounted for this results.

scholarly journals NONINVASIVE ESTIMATION OF INFARCT SIZE BY ECHOCARDIOGRAPHIC CORONARY FLOW IN A MOUSE MODEL OF MYOCARDIAL INFARCTION

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E127.2-E128 ◽  
Author(s):  
Jian Wu ◽  
Jieyun ◽  
Guoliang Jiang ◽  
Lei Li ◽  
Aili Guan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mouse Model ◽  
Infarct Size ◽  
Coronary Flow ◽  
Noninvasive Estimation

scholarly journals Thymoquinone enhances coronary flow and reduces infarct size in Langendorff‐perfused rat hearts through attenuation of inflammatory responce and apoptosis

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Raed S Ismail ◽  
El‐Sayed M El‐Sayed ◽  
Ahmed M Mansour ◽  
Mohamed A El‐Mahdy ◽  
Jay L Zweier
Keyword(s):  
Infarct Size ◽  
Coronary Flow ◽  
Rat Hearts ◽  
Perfused Rat Hearts
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