Nitric oxide and Na,K-ATPase activity in rat skeletal muscle

2015 ◽  
Vol 216 (4) ◽  
pp. 447-453 ◽  
Author(s):  
C. Juel
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Atpase Activity ◽  
Rat Skeletal Muscle

293 EVIDENCE FOR DIRECT RELEASE OF NITRIC OXIDE FROM INCUBATED RAT SKELETAL MUSCLE

1994 ◽  
Vol 26 (Supplement) ◽  
pp. S52
Author(s):  
T. W. Dalon ◽  
A. Jasman ◽  
R. J. Ding ◽  
J. L. Nadler
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Rat Skeletal Muscle

Regulation of inducible nitric oxide synthase expression in L6 rat skeletal muscle cells

1997 ◽  
Vol 272 (1) ◽  
pp. C35-C40 ◽  
Author(s):  
S. Okuda ◽  
F. Kanda ◽  
Y. Kawahara ◽  
K. Chihara
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Protein Kinase ◽  
Nitric Oxide Synthase ◽  
Tyrosine Kinase ◽  
Muscle Cells ◽  
Inos Expression ◽  
Skeletal Muscle Cells ◽  
Rat Skeletal Muscle ◽  
Oxide Synthase

Cytokine-stimulated expression of inducible type of nitric oxide synthase (iNOS) seems to be regulated by various signal pathways in a cell-specific manner. In this study, we examined how it was regulated in L6 rat skeletal muscle cells. In L6 cells, the combination of interleukin-1 beta and interferon-gamma induced a marked accumulation of nitrite, a stable metabolite of nitric oxide. In parallel with this reaction, iNOS mRNA expression was achieved at a maximum between 3 and 6 h, and iNOS protein was detectable at 6 h and peaked at 24 h after stimulation. Tyrosine kinase inhibitors, herbimycin A, and genistein suppressed cytokine-induced iNOS expression and nitrite production. Forskolin, an adenosine 3',5'-cyclic monophosphate-dependent protein kinase (PKA) activator, and phorbol 12-myristate 13-acetate, a protein kinase C (PKC)-activating phorbol ester, enhanced these cytokine-induced reactions. These results indicate that iNOS expression by cytokines is mediated via a protein tyrosine kinase-dependent pathway and is positively modulated by both PKA- and PKC-dependent pathways in this cell type.

scholarly journals Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

AGE ◽  
2012 ◽  
Vol 35 (4) ◽  
pp. 1061-1075 ◽  
Author(s):  
Emanuele Marzetti ◽  
Riccardo Calvani ◽  
Jameson DuPree ◽  
Hazel A. Lees ◽  
Silvia Giovannini ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Late Life ◽  
Rat Skeletal Muscle ◽  
Metabolic Adaptations

Role of Neuronal Nitric Oxide Synthase in Modulating Microvascular and Contractile Function in Rat Skeletal Muscle

2011 ◽  
Vol 18 (6) ◽  
pp. 501-511 ◽  
Author(s):  
STEVEN W. COPP ◽  
DANIEL M. HIRAI ◽  
SCOTT K. FERGUSON ◽  
TIMOTHY I. MUSCH ◽  
DAVID C. POOLE
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Contractile Function ◽  
Neuronal Nitric Oxide Synthase ◽  
Rat Skeletal Muscle ◽  
Oxide Synthase
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