scholarly journals Mechanistic insights into the functional role of vascular endothelial growth factor and its signalling partner brain-derived neurotrophic factor in angiogenic tube formation

2014 ◽  
Vol 211 (2) ◽  
pp. 268-270 ◽  
Author(s):  
E. Deindl
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factor ◽  
Functional Role ◽  
Brain Derived Neurotrophic Factor ◽  
Tube Formation ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Brendan P. Murphy ◽  
Terence Y. Pang ◽  
Anthony J. Hannan ◽  
Tina-Marie Proffitt ◽  
Mirabel McConchie ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
First Episode Psychosis ◽  
First Episode ◽  
Vascular Endothelial ◽  
Episode Psychosis ◽  
Endothelial Growth Factor ◽  
Serum Bdnf

Objective. It has been suggested that atypical antipsychotics confer their effects via brain-derived neurotrophic factor (BDNF). We investigated the effect of quetiapine on serum levels of BDNF and vascular endothelial growth factor (VEGF) in drug-naive first-episode psychosis subjects.Methods. Fifteen patients drawn from a larger study received quetiapine treatment for twelve weeks. Baseline levels of serum BDNF and VEGF were compared to age- and sex-matched healthy controls and to levels following treatment. Linear regression analyses were performed to determine the relationship of BDNF and VEGF levels with outcome measures at baseline and week 12.Results. The mean serum BDNF level was significantly higher at week 12 compared to baseline and correlated with reductions in Brief Psychiatric Rating Scale (BPRS) and general psychopathology scores. Changes in serum VEGF levels also correlated significantly with a reduction in BPRS scores, a significant improvement in PANNS positive symptoms scores, and displayed a positive relationship with changes in BDNF levels.Conclusions. Our findings suggest that BDNF and VEGF are potential biomarkers for gauging improvement of psychotic symptoms. This suggests a novel neurotrophic-based mechanism of the drug effects of quetiapine on psychosis. This is the first report of VEGF perturbation in psychosis.

scholarly journals Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Mehrdad Afarid ◽  
Ehsan Namvar ◽  
Fatemeh Sanie-Jahromi
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Diabetic Retinopathy ◽  
Growth Factor ◽  
Neurotrophic Factor ◽  
Inflammatory Responses ◽  
Brain Derived Neurotrophic Factor ◽  
Clinical Aspects ◽  
Main Step ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Impairment of neuroprotection and vasculopathy are the main reasons for the progression of diabetic retinopathy. In this review, we decided to illustrate the molecular and clinical aspects of diabetic retinal neuro-vasculopathy. We searched the Web of Science, PubMed, and Scopus databases with these keywords: “brain-derived neurotrophic factor” and “vascular endothelial growth factor” and/or “diabetic retinopathy.” The most relevant in vitro and clinical trial studies were then extracted for final interpretation. Brain-derived neurotrophic factor and the vascular endothelial growth factor have pivotal roles in the pathogenesis of diabetic retinopathy. They have neuroprotective effects on the retina. However, there are controversial results on the relation between these two factors. Reviewing available articles, we have concluded that various concentrations of these molecules at different stages of retinopathy may exert different effects. Optimal doses of the brain-derived neurotrophic factor at the early stages of retinopathy may have a neuroprotective effect. In contrast, higher concentrations of brain-derived neurotrophic factor might induce inflammatory responses. Damage to the retinal cells due to metabolic alterations associated with diabetes and its consequence vasculopathy may also lead to changes in the ocular microenvironment and cytokines. Changes in cytokines result in the modification of neural cell receptors and the overproduction of vascular endothelial growth factor. It seems that controlling the optimal levels of neuroprotective molecules in the retinal tissue is the main step to halter diabetic retinopathy.

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