Postnatal development of the renal medulla; role of the renin-angiotensin system

2013 ◽  
Vol 208 (1) ◽  
pp. 41-49 ◽  
Author(s):  
K. Madsen ◽  
A. R. Tinning ◽  
N. Marcussen ◽  
B. L. Jensen
Keyword(s):  
Postnatal Development ◽  
Renin Angiotensin System ◽  
Renal Medulla ◽  
Angiotensin System ◽  
Renin Angiotensin

Reversal of renovascular hypertension: role of the renal medulla

1987 ◽  
Vol 65 (8) ◽  
pp. 1566-1571 ◽  
Author(s):  
J. D. Swales ◽  
R. F. Bing ◽  
M. E. Edmunds ◽  
G. I. Russell ◽  
H. Thurston
Keyword(s):  
Blood Pressure ◽  
Renovascular Hypertension ◽  
Peripheral Resistance ◽  
Renin Angiotensin System ◽  
Renal Medulla ◽  
Pressure Control ◽  
Sodium Retention ◽  
Angiotensin System ◽  
Renin Angiotensin

The fall in blood pressure, which occurs when renovascular hypertension is corrected surgically, offers a means of elucidating the factors responsible for blood pressure control. When Goldblatt two-kidney, one-clip hypertension in the rat is reversed by unclipping the renal artery, or by removal of the ischaemic kidney, restoration of normal blood pressure is due to a fall in peripheral resistance. This is associated with sodium retention and cannot be modified by inhibition of the renin–angiotensin system. The fall is, however, partially inhibited by chemical removal of the renal medulla by means of 2-bromo-ethylamine hydrobromide. When normal rats are chemically medullectomized, moderate hypertension is produced, which cannot be attributed to the renin–angiotensin system or sodium retention. It is concluded that a renomedullary vasodepressor system is ablated by chemical medullectomy: further, this system plays a role in the surgical correction of Goldblatt hypertension.

Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal disease

2001 ◽  
Vol 21 (6) ◽  
pp. 580-592 ◽  
Author(s):  
Arnold Boonstra ◽  
Dick de Zeeuw ◽  
Paul E. de Jong ◽  
Gerjan Navis
Keyword(s):  
Genetic Variability ◽  
Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

The Renin Angiotensin System and Bipolar Disorder: A Systematic Review

2020 ◽  
Vol 27 (6) ◽  
pp. 520-528 ◽  
Author(s):  
Izabela Guimarães Barbosa ◽  
Giulia Campos Ferreira ◽  
Diomildo Ferreira Andrade Júnior ◽  
Cássio Rocha Januário ◽  
André Rolim Belisário ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Cardiovascular Diseases ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Angiotensin Receptors ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Search Terms

Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.

The renin-angiotensin system in kidney development: role of COX-2 and adrenal steroids

2004 ◽  
Vol 181 (4) ◽  
pp. 549-559 ◽  
Author(s):  
B. L. Jensen ◽  
J. Stubbe ◽  
K. Madsen ◽  
F. T. Nielsen ◽  
O. Skott
Keyword(s):  
Kidney Development ◽  
Renin Angiotensin System ◽  
Adrenal Steroids ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Cox 2

ROLE OF RENIN-ANGIOTENSIN SYSTEM IN RADIATION-INDUCED LUNG INJURY

CHEST Journal ◽  
2008 ◽  
Vol 134 (4) ◽  
pp. 127P ◽  
Author(s):  
Rade Tomic ◽  
Elizabeth Jacobs ◽  
Metha Medhora ◽  
Andreea Antonescu-Turcu ◽  
Ghosh Swarajit
Keyword(s):  
Lung Injury ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Radiation Induced
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