Local protocol helped to deliver vitamin D levels more accurately in preterm infants

Evaluation of Maternal and Infantile Levels of Vitamin D in Preterm Infants

Current Pediatric Reviews ◽

10.2174/1573396317666211006153153 ◽

2021 ◽

Vol 17 ◽

Author(s):

Hassan Boskabadi ◽

Ali Moradi ◽

Maryam Zakerihamidi

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Preterm Infants ◽

Premature Infants ◽

Serum Levels ◽

Severe Deficiency ◽

Vitamin D Levels ◽

The Difference ◽

D 20 ◽

D Values

Introduction: Vitamin D deficiency is highly prevalent during pregnancy and in premature infants. This study was done to investigate the maternal and infantile levels of vitamin D in preterm infants. Methods: Using available sampling during 2018-2020 the maternal and umbilical cord serum levels of vitamin D were measured in 294 premature infants in Ghaem Hospital, Mashhad, Iran. A researcher-made questionnaire containing neonatal demographic and clinical characteristics was used as data collection tool. Both maternal and placental vitamin D levels were categorized into four classes: severe deficiency (vitamin D<10 ng/ml), moderate deficiency (10.1≤vitamin D≤20 ng/ml), mild deficiency (20.1≤vitamin D≤30 ng/ml) and normal (vitamin D >30.1ng ml). Results: Vitamin D deficiency was seen in 89% of premature infants (46.6% severe, 30.6% moderate, and 11.9% mild). Serum levels of vitamin D were 18.28±13.94 ng/ml and 14.10±9.70 ng/ml in mothers and infants, respectively. The infants below and above 32 weeks had vitamin D values of: 10.97±6.31 ng/ml and 18.05±11.64 ng/ml, respectively. The difference in vitamin D levels between boys (12.59±8.40 ng/ml) and girls (16.05±11.45 ng/ml) was significant (P=0.009). Moderate and severe vitamin D deficiency were more common at earlier pregnancy ages (P=0.001). Conclusion: Vitamin D deficiency is more common and severe in preterm infants and their mothers. Controlling vitamin D level during pregnancy, especially in women at risk of preterm labor and preterm infants may help reduce prematurity problems.

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Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

10.20944/preprints202108.0507.v1 ◽

2021 ◽

Author(s):

Alicja Kołodziejczyk-Nowotarska ◽

Renata Bokiniec ◽

Joanna Seliga-Siwecka

Keyword(s):

Vitamin D ◽

Preterm Infants ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

Control Group ◽

Randomized Controlled ◽

Vitamin D Levels ◽

Ultrasound Findings ◽

To Receive ◽

Vitamin D Toxicity

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n=55; approximately 800-1000 IU from combined sources) or monitored therapy (n=54; with an option of dose modification). 25(OH)D concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52±2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (&gt;90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20–80 ng/mL) at 52 weeks of PCA (p=0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

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390 Do Fractures Correlate with Vitamin D Levels in Preterm Infants?

Pediatric Research ◽

10.1203/00006450-201011001-00390 ◽

2010 ◽

Vol 68 ◽

pp. 201-201

Author(s):

M McGann ◽

R Mccarthy ◽

O Uduma ◽

J Brady ◽

M Mckenna ◽

...

Keyword(s):

Vitamin D ◽

Preterm Infants ◽

Vitamin D Levels

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1126 Vitamin D Levels and Myocardial Function in Preterm Infants

Archives of Disease in Childhood ◽

10.1136/archdischild-2012-302724.1126 ◽

2012 ◽

Vol 97 (Suppl 2) ◽

pp. A323-A323 ◽

Cited By ~ 1

Author(s):

K. Armstrong ◽

C. Onwunmeme ◽

O. Franklin ◽

E. Molloy

Keyword(s):

Vitamin D ◽

Preterm Infants ◽

Myocardial Function ◽

Vitamin D Levels

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Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Nutrients ◽

10.3390/nu13103442 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3442

Author(s):

Alicja Kołodziejczyk-Nowotarska ◽

Renata Bokiniec ◽

Joanna Seliga-Siwecka

Keyword(s):

Vitamin D ◽

Preterm Infants ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

Control Group ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Ultrasound Findings ◽

25 Hydroxyvitamin D ◽

To Receive

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20−80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

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Vitamin D deficiency and morbidity among preterm infants in a developing country

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20170697 ◽

2017 ◽

Vol 4 (2) ◽

pp. 499 ◽

Cited By ~ 2

Author(s):

Nitin Srinivasan ◽

Jayasree Chandramathi ◽

Aswin S. Prabhu ◽

Sasidharan Ponthenkandath

Keyword(s):

Vitamin D ◽

Clinical Outcome ◽

Cord Blood ◽

Preterm Infants ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Blood Levels ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Relationship Of

Background: The association of serum vitamin D levels to clinical outcome in VLBW infants has not been studied. Our objective was to measure the cord blood levels, and the dose response for two doses of vitamin D in preterm infants and correlate the relationship of vitamin D levels to the clinical outcome.Methods: We prospectively obtained cord blood levels in 80 preterm infants under 34 weeks gestation (mean gestation age 29±2 weeks and BW: 1210±350 gms). Infants were supplemented with 400 IU or 800-1000 IU vitamin D daily. Serun vitamin D levels were obtained at 2 - 3 weeks after supplementation and levels were correlated to clinical outcome. Results: The mean cord blood vitamin D level was 12±8.5 ng/ml. Babies who developed sepsis and compared to those who did not develop these morbidities, ROP had vitamin D levels: 13.5±6 (ng/ml) versus 30.5±10 (ng/ml) (p < 0.01) and 15.7±11 (ng/ml) versus 34±18 (ng/ml) (p <0.03) respectively. Supplementation with 400 IU vitamin D resulted in levels of 17±8.6 (ng/ml) and infants given 800-1000 IU vitamin D had levels 46±17(ng/ml) (p <0.001).Conclusions: These data suggest that cord blood vitamin D levels are low in preterm infants and 800-1000 IU vitamin D supplementation is advisable to achieve levels >30 ng/ml. Infants with low levels of vitamin D have higher incidence of sepsis, and ROP.

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Plasma vitamin D levels at birth and immune status of preterm infants

Immunobiology ◽

10.1016/j.imbio.2016.06.001 ◽

2016 ◽

Vol 221 (11) ◽

pp. 1289-1292 ◽

Cited By ~ 5

Author(s):

Florentina Sava ◽

András Treszl ◽

Júlia Hajdú ◽

Gergely Toldi ◽

János Rigó ◽

...

Keyword(s):

Vitamin D ◽

Preterm Infants ◽

Immune Status ◽

Plasma Vitamin ◽

Vitamin D Levels

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Vitamin D Status and Factors Associated with Vitamin D Deficiency during the First Year of Life in Preterm Infants

Nutrients ◽

10.3390/nu13062019 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2019

Author(s):

Jae-Hun Jung ◽

Eun-Ah Kim ◽

Sang-Yoon Lee ◽

Jung-Eun Moon ◽

Eun-Joo Lee ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Preterm Infants ◽

Vitamin D Supplementation ◽

First Year ◽

Factors Associated ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

National University ◽

First Year Of Life

We aimed to investigate the changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) during the first year of life in Korean preterm infants. We enrolled 333 preterm infants who were born at Kyungpook National University Children’s Hospital between March 2013 and December 2019. 25-hydroxyvitamin D (25-OHD) levels and medical records were collected at birth, 6 months, and 12 months of age. The mean gestational age was 33.4 ± 2.3 weeks and mean 25-OHD levels at birth were 18.2 ± 13.5 ng/mL. The incidence of VDD was 82.8%, 30.6%, and 27.0% at birth, 6 months, and 12 months, respectively. The incidence of severe VDD (25-OHD < 10 ng/mL) was 31.5%, 1.5%, and 0%, at birth, 6 months, and 12 months, respectively. Among infants with severe VDD, the deficiency persisted in 49.6% at 6 months, and 35.3% at 12 months. The strongest predictor of VDD during follow-up was 25-OHD concentration at birth. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Therefore, it is important to prevent neonatal VDD through maternal vitamin D supplementation during pregnancy. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants.

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