scholarly journals Decreased airway epithelial ion transport was associated with the severity of the respiratory syncytial virus infection and complications in infants

2020 ◽  
Vol 109 (11) ◽  
pp. 2313-2315 ◽  
Author(s):  
Anu Kaskinen ◽  
Adam Alexandersson ◽  
Sture Andersson ◽  
Harri Saxén ◽  
Ville Peltola ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Ion Transport ◽  
Respiratory Syncytial Virus Infection ◽  
Airway Epithelial ◽  
Epithelial Ion Transport ◽  
Syncytial Virus

scholarly journals Role of CCR3 in Respiratory Syncytial Virus infection of Airway Epithelial Cells

iScience ◽  
2021 ◽  
pp. 103433
Author(s):  
Vincent Wellemans ◽  
Hassan Ait Benhassou ◽  
Eloise Fuselier ◽  
Fabienne Bellesort ◽  
Sandra Dury ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Syncytial Virus

scholarly journals Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection

Pathogens ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 106 ◽  
Author(s):  
Glaser ◽  
Coulter ◽  
Shields ◽  
Touzelet ◽  
Power ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Immune Cells ◽  
Airway Epithelial ◽  
Antiviral Immune Response ◽  
Cytokines And Chemokines ◽  
Rsv Infection ◽  
Syncytial Virus

The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. This paper provides a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during respiratory syncytial virus (RSV) infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemo-attraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. The reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. It is argued that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field.

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